Motilin, ghrelin and related neuropeptides as targets for the treatment of GI diseases

Motilin and ghrelin are released from the upper gut during fasting, to stimulate gastric motility. Additional actions of ghrelin (e.g. changes in appetite, nausea or endocrine functions) improve the possibility of using ghrelin receptor agonists to treat complex disorders such as functional dyspepsi...

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Veröffentlicht in:	Drug discovery today 2008-03, Vol.13 (5), p.234-239
1. Verfasser:	Sanger, Gareth J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Digestive system Gastrointestinal Agents - therapeutic use Gastrointestinal Diseases - drug therapy Gastrointestinal Diseases - metabolism Gastrointestinal Motility - physiology Ghrelin - metabolism Ghrelin - physiology Humans Medical sciences Motilin - metabolism Motilin - physiology Pharmacology. Drug treatments Receptors, Gastrointestinal Hormone - agonists Receptors, Gastrointestinal Hormone - antagonists & inhibitors Receptors, Gastrointestinal Hormone - metabolism Receptors, Gastrointestinal Hormone - physiology Receptors, Ghrelin - agonists Receptors, Ghrelin - antagonists & inhibitors Receptors, Ghrelin - metabolism Receptors, Ghrelin - physiology Receptors, Neuropeptide - agonists Receptors, Neuropeptide - antagonists & inhibitors Receptors, Neuropeptide - metabolism Receptors, Neuropeptide - physiology
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