Motilin, ghrelin and related neuropeptides as targets for the treatment of GI diseases
Motilin and ghrelin are released from the upper gut during fasting, to stimulate gastric motility. Additional actions of ghrelin (e.g. changes in appetite, nausea or endocrine functions) improve the possibility of using ghrelin receptor agonists to treat complex disorders such as functional dyspepsi...
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| Veröffentlicht in: | Drug discovery today 2008-03, Vol.13 (5), p.234-239 |
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| creator | Sanger, Gareth J. |
| description | Motilin and ghrelin are released from the upper gut during fasting, to stimulate gastric motility. Additional actions of ghrelin (e.g. changes in appetite, nausea or endocrine functions) improve the possibility of using ghrelin receptor agonists to treat complex disorders such as functional dyspepsia. However, changes in endocrine functions increase the risk of unacceptable side effects. By comparison, the more restricted prokinetic activity of motilin limits the therapeutic possibilities but improves the risk:benefit ratio. Compounds targeting both receptors are in development. Recently, additional peptides have been identified from preproghrelin (obestatin) and prepromotilin. These exert biological activity but their pathophysiological significance is unknown. |
| doi_str_mv | 10.1016/j.drudis.2007.10.024 |
| format | Article |
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Additional actions of ghrelin (e.g. changes in appetite, nausea or endocrine functions) improve the possibility of using ghrelin receptor agonists to treat complex disorders such as functional dyspepsia. However, changes in endocrine functions increase the risk of unacceptable side effects. By comparison, the more restricted prokinetic activity of motilin limits the therapeutic possibilities but improves the risk:benefit ratio. Compounds targeting both receptors are in development. Recently, additional peptides have been identified from preproghrelin (obestatin) and prepromotilin. These exert biological activity but their pathophysiological significance is unknown.</description><subject>Biological and medical sciences</subject><subject>Digestive system</subject><subject>Gastrointestinal Agents - therapeutic use</subject><subject>Gastrointestinal Diseases - drug therapy</subject><subject>Gastrointestinal Diseases - metabolism</subject><subject>Gastrointestinal Motility - physiology</subject><subject>Ghrelin - metabolism</subject><subject>Ghrelin - physiology</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Motilin - metabolism</subject><subject>Motilin - physiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Receptors, Gastrointestinal Hormone - agonists</subject><subject>Receptors, Gastrointestinal Hormone - antagonists & inhibitors</subject><subject>Receptors, Gastrointestinal Hormone - metabolism</subject><subject>Receptors, Gastrointestinal Hormone - physiology</subject><subject>Receptors, Ghrelin - agonists</subject><subject>Receptors, Ghrelin - antagonists & inhibitors</subject><subject>Receptors, Ghrelin - metabolism</subject><subject>Receptors, Ghrelin - physiology</subject><subject>Receptors, Neuropeptide - agonists</subject><subject>Receptors, Neuropeptide - antagonists & inhibitors</subject><subject>Receptors, Neuropeptide - metabolism</subject><subject>Receptors, Neuropeptide - physiology</subject><issn>1359-6446</issn><issn>1878-5832</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtuFDEQRS0Eyov8QRR5A6v04Pdjg4Qi8pCC2ABby90uJx71dA-2OxJ_j4cZlB2s6qp06qp0ELqgZEUJVR_Wq5CXkMqKEaLbakWYeIVOqNGmk4az1y1zaTslhDpGp6WsCaHMSnWEjqnhgmlrT9CPL3NNY5qu8ONThhawnwJuyVcIeIIlz1vY1hSgYF9w9fkRasFxzrg-Aa4ZfN3AVPEc8e09bv-AL1DeojfRjwXOD_MMfb_5_O36rnv4ent__emhG4TRtVPSGkX7IG1kvTLRALdAbRCRRKDeEKO4ACt7a0U0kkXmLfSyl4J4rbTmZ-j9vneb558LlOo2qQwwjn6CeSlOE24Nof8HGdGMCsMbKPbgkOdSMkS3zWnj8y9HiduJd2u3F-924nfbJr6dXR76l34D4eXoYLoB7w6AL4MfY_bT0Dr-coxQq_ifRz_uOWjanhNkV4YE0wAhZRiqC3P69ye_ATSioqw</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Sanger, Gareth J.</creator><general>Elsevier Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20080301</creationdate><title>Motilin, ghrelin and related neuropeptides as targets for the treatment of GI diseases</title><author>Sanger, Gareth J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-659861bd59f2b68f8e39e19d4f0fe1a808634e95b994f852f2a9eb5b540a76773</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Biological and medical sciences</topic><topic>Digestive system</topic><topic>Gastrointestinal Agents - therapeutic use</topic><topic>Gastrointestinal Diseases - drug therapy</topic><topic>Gastrointestinal Diseases - metabolism</topic><topic>Gastrointestinal Motility - physiology</topic><topic>Ghrelin - metabolism</topic><topic>Ghrelin - physiology</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Motilin - metabolism</topic><topic>Motilin - physiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Receptors, Gastrointestinal Hormone - agonists</topic><topic>Receptors, Gastrointestinal Hormone - antagonists & inhibitors</topic><topic>Receptors, Gastrointestinal Hormone - metabolism</topic><topic>Receptors, Gastrointestinal Hormone - physiology</topic><topic>Receptors, Ghrelin - agonists</topic><topic>Receptors, Ghrelin - antagonists & inhibitors</topic><topic>Receptors, Ghrelin - metabolism</topic><topic>Receptors, Ghrelin - physiology</topic><topic>Receptors, Neuropeptide - agonists</topic><topic>Receptors, Neuropeptide - antagonists & inhibitors</topic><topic>Receptors, Neuropeptide - metabolism</topic><topic>Receptors, Neuropeptide - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sanger, Gareth J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Drug discovery today</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sanger, Gareth J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Motilin, ghrelin and related neuropeptides as targets for the treatment of GI diseases</atitle><jtitle>Drug discovery today</jtitle><addtitle>Drug Discov Today</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>13</volume><issue>5</issue><spage>234</spage><epage>239</epage><pages>234-239</pages><issn>1359-6446</issn><eissn>1878-5832</eissn><abstract>Motilin and ghrelin are released from the upper gut during fasting, to stimulate gastric motility. 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| fulltext | fulltext |
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| ispartof | Drug discovery today, 2008-03, Vol.13 (5), p.234-239 |
| issn | 1359-6446 1878-5832 |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Biological and medical sciences Digestive system Gastrointestinal Agents - therapeutic use Gastrointestinal Diseases - drug therapy Gastrointestinal Diseases - metabolism Gastrointestinal Motility - physiology Ghrelin - metabolism Ghrelin - physiology Humans Medical sciences Motilin - metabolism Motilin - physiology Pharmacology. Drug treatments Receptors, Gastrointestinal Hormone - agonists Receptors, Gastrointestinal Hormone - antagonists & inhibitors Receptors, Gastrointestinal Hormone - metabolism Receptors, Gastrointestinal Hormone - physiology Receptors, Ghrelin - agonists Receptors, Ghrelin - antagonists & inhibitors Receptors, Ghrelin - metabolism Receptors, Ghrelin - physiology Receptors, Neuropeptide - agonists Receptors, Neuropeptide - antagonists & inhibitors Receptors, Neuropeptide - metabolism Receptors, Neuropeptide - physiology |
| title | Motilin, ghrelin and related neuropeptides as targets for the treatment of GI diseases |
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