Neutrophil Elastase Up-Regulates Cathepsin B and Matrix Metalloprotease-2 Expression

Neutrophil elastase (NE) activity is increased in many diseases. Other families of proteases, including cathepsins and matrix metalloproteases (MMPs), are also present at elevated levels in similar disease conditions. We postulated that NE could induce expression of cathepsins and MMPs in human macr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of Immunology 2007-05, Vol.178 (9), p.5871-5878
Hauptverfasser:	Geraghty, Patrick, Rogan, Mark P, Greene, Catherine M, Boxio, Rachel M. M, Poiriert, Tiphaine, O'Mahony, Michael, Belaaouaj, Abderazzaq, O'Neill, Shane J, Taggart, Clifford C, McElvaney, Noel G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cathepsin B - genetics Cathepsin B - metabolism Genes, Dominant Humans Interleukin-1 Receptor-Associated Kinases - genetics Interleukin-1 Receptor-Associated Kinases - metabolism Interleukin-8 - metabolism Leukocyte Elastase - genetics Leukocyte Elastase - pharmacology Leukocyte Elastase - physiology Lung - immunology Lung - microbiology Macrophages - drug effects Macrophages - enzymology Macrophages - immunology Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Mice Mice, Knockout NF-kappa B - metabolism Pseudomonas aeruginosa Pseudomonas Infections - immunology Toll-Like Receptor 4 - metabolism Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!