How valuable is measurement of peripheral blood natural killer cells at the time of abortion?
Increased peripheral blood natural killer (NK) cells are associated to immune-mediated abortion, but their diagnostic value when measured at the time of miscarriage is unknown. In women with therapeutic (A = 79) or elective (C = 34) pregnancy termination, the NK-cell percentage was measured before a...
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| Veröffentlicht in: | American journal of reproductive immunology (1989) 2008-04, Vol.59 (4), p.306-315 |
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| container_title | American journal of reproductive immunology (1989) |
| container_volume | 59 |
| creator | Paparistidis, Nikolaos Papadopoulou, Chryssa Chioti, Athanassia Papaioannou, Demetrios Tsekoura, Christina Keramitsoglou, Theodora Kontopoulou-Antonopoulou, Virginia Agapitos, Emmanouel Balafoutas, Christos Varla-Leftherioti, Marighoula |
| description | Increased peripheral blood natural killer (NK) cells are associated to immune-mediated abortion, but their diagnostic value when measured at the time of miscarriage is unknown.
In women with therapeutic (A = 79) or elective (C = 34) pregnancy termination, the NK-cell percentage was measured before and 5 days after curettage. Additionally, immune-mediated lesions (scored 0-3) and CD56(+) and CD16(+) decidual NKs (scored 1-3) were detected on the abortion material.
Aborters differed from controls in histological scores (P = 0.000) and in NK percentage (>12%) only in the measurement 5 days after the operation (P = 0.038). In comparison to histological lesions, NK measurement was found to have sensitivity 70%, specificity 73.68%, positive prognostic value 89.39% and negative prognostic value 43.75%.
An Increased NK-cell percentage 5 days after the pregnancy termination could be a marker of immune aetiology of miscarriage, as the probability of an aborter with NK >12% to have an immune-mediated abortion is almost 90%. |
| doi_str_mv | 10.1111/j.1600-0897.2007.00547.x |
| format | Article |
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In women with therapeutic (A = 79) or elective (C = 34) pregnancy termination, the NK-cell percentage was measured before and 5 days after curettage. Additionally, immune-mediated lesions (scored 0-3) and CD56(+) and CD16(+) decidual NKs (scored 1-3) were detected on the abortion material.
Aborters differed from controls in histological scores (P = 0.000) and in NK percentage (>12%) only in the measurement 5 days after the operation (P = 0.038). In comparison to histological lesions, NK measurement was found to have sensitivity 70%, specificity 73.68%, positive prognostic value 89.39% and negative prognostic value 43.75%.
An Increased NK-cell percentage 5 days after the pregnancy termination could be a marker of immune aetiology of miscarriage, as the probability of an aborter with NK >12% to have an immune-mediated abortion is almost 90%.</description><identifier>ISSN: 1046-7408</identifier><identifier>DOI: 10.1111/j.1600-0897.2007.00547.x</identifier><identifier>PMID: 18294356</identifier><language>eng</language><publisher>Denmark</publisher><subject>Abortion, Missed - blood ; Abortion, Missed - diagnosis ; Abortion, Missed - immunology ; Abortion, Missed - pathology ; Adult ; Antibodies, Monoclonal - immunology ; CD56 Antigen - analysis ; Chorionic Villi - immunology ; Chorionic Villi - pathology ; Female ; Humans ; Immunohistochemistry ; Keratins - analysis ; Keratins - immunology ; Killer Cells, Natural - cytology ; Killer Cells, Natural - immunology ; Lymphocyte Count ; Predictive Value of Tests ; Receptors, IgG - analysis ; Time Factors</subject><ispartof>American journal of reproductive immunology (1989), 2008-04, Vol.59 (4), p.306-315</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18294356$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Paparistidis, Nikolaos</creatorcontrib><creatorcontrib>Papadopoulou, Chryssa</creatorcontrib><creatorcontrib>Chioti, Athanassia</creatorcontrib><creatorcontrib>Papaioannou, Demetrios</creatorcontrib><creatorcontrib>Tsekoura, Christina</creatorcontrib><creatorcontrib>Keramitsoglou, Theodora</creatorcontrib><creatorcontrib>Kontopoulou-Antonopoulou, Virginia</creatorcontrib><creatorcontrib>Agapitos, Emmanouel</creatorcontrib><creatorcontrib>Balafoutas, Christos</creatorcontrib><creatorcontrib>Varla-Leftherioti, Marighoula</creatorcontrib><title>How valuable is measurement of peripheral blood natural killer cells at the time of abortion?</title><title>American journal of reproductive immunology (1989)</title><addtitle>Am J Reprod Immunol</addtitle><description>Increased peripheral blood natural killer (NK) cells are associated to immune-mediated abortion, but their diagnostic value when measured at the time of miscarriage is unknown.
In women with therapeutic (A = 79) or elective (C = 34) pregnancy termination, the NK-cell percentage was measured before and 5 days after curettage. Additionally, immune-mediated lesions (scored 0-3) and CD56(+) and CD16(+) decidual NKs (scored 1-3) were detected on the abortion material.
Aborters differed from controls in histological scores (P = 0.000) and in NK percentage (>12%) only in the measurement 5 days after the operation (P = 0.038). In comparison to histological lesions, NK measurement was found to have sensitivity 70%, specificity 73.68%, positive prognostic value 89.39% and negative prognostic value 43.75%.
An Increased NK-cell percentage 5 days after the pregnancy termination could be a marker of immune aetiology of miscarriage, as the probability of an aborter with NK >12% to have an immune-mediated abortion is almost 90%.</description><subject>Abortion, Missed - blood</subject><subject>Abortion, Missed - diagnosis</subject><subject>Abortion, Missed - immunology</subject><subject>Abortion, Missed - pathology</subject><subject>Adult</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>CD56 Antigen - analysis</subject><subject>Chorionic Villi - immunology</subject><subject>Chorionic Villi - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Keratins - analysis</subject><subject>Keratins - immunology</subject><subject>Killer Cells, Natural - cytology</subject><subject>Killer Cells, Natural - immunology</subject><subject>Lymphocyte Count</subject><subject>Predictive Value of Tests</subject><subject>Receptors, IgG - analysis</subject><subject>Time Factors</subject><issn>1046-7408</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kMtOwzAQRb0A0VL4BeQVu4Sxx42TFUIVUKRKbGCJIqeeqilOHWyHx9-TijKb0Ujnjo4uY1xALsa52eWiAMigrHQuAXQOMFc6_z5hUwGqyLSCcsLOY9wBjBDqMzYRpawUzospe1v6L_5p3GAaR7yNvCMTh0Ad7RP3G95TaPstBeN447y3fG_ScLjeW-co8DU5F7lJPG2Jp7ajQ8g0PqTW728v2OnGuEiXxz1jrw_3L4tltnp-fFrcrbJeQpUytLoRozsgSVJEuFYK1gIbaCxqU1qyQihlBVYaAbHaiErakZSoSBQSZ-z6728f_MdAMdVdGw9qZk9-iLUGrAqUxQheHcGh6cjWfWg7E37q_0LwF5ANYlI</recordid><startdate>200804</startdate><enddate>200804</enddate><creator>Paparistidis, Nikolaos</creator><creator>Papadopoulou, Chryssa</creator><creator>Chioti, Athanassia</creator><creator>Papaioannou, Demetrios</creator><creator>Tsekoura, Christina</creator><creator>Keramitsoglou, Theodora</creator><creator>Kontopoulou-Antonopoulou, Virginia</creator><creator>Agapitos, Emmanouel</creator><creator>Balafoutas, Christos</creator><creator>Varla-Leftherioti, Marighoula</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200804</creationdate><title>How valuable is measurement of peripheral blood natural killer cells at the time of abortion?</title><author>Paparistidis, Nikolaos ; Papadopoulou, Chryssa ; Chioti, Athanassia ; Papaioannou, Demetrios ; Tsekoura, Christina ; Keramitsoglou, Theodora ; Kontopoulou-Antonopoulou, Virginia ; Agapitos, Emmanouel ; Balafoutas, Christos ; Varla-Leftherioti, Marighoula</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p209t-3d7b120003e2e4ee3c440c13b0bd37a8ded1144d139730339f192de4e234e1623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Abortion, Missed - blood</topic><topic>Abortion, Missed - diagnosis</topic><topic>Abortion, Missed - immunology</topic><topic>Abortion, Missed - pathology</topic><topic>Adult</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>CD56 Antigen - analysis</topic><topic>Chorionic Villi - immunology</topic><topic>Chorionic Villi - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Keratins - analysis</topic><topic>Keratins - immunology</topic><topic>Killer Cells, Natural - cytology</topic><topic>Killer Cells, Natural - immunology</topic><topic>Lymphocyte Count</topic><topic>Predictive Value of Tests</topic><topic>Receptors, IgG - analysis</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Paparistidis, Nikolaos</creatorcontrib><creatorcontrib>Papadopoulou, Chryssa</creatorcontrib><creatorcontrib>Chioti, Athanassia</creatorcontrib><creatorcontrib>Papaioannou, Demetrios</creatorcontrib><creatorcontrib>Tsekoura, Christina</creatorcontrib><creatorcontrib>Keramitsoglou, Theodora</creatorcontrib><creatorcontrib>Kontopoulou-Antonopoulou, Virginia</creatorcontrib><creatorcontrib>Agapitos, Emmanouel</creatorcontrib><creatorcontrib>Balafoutas, Christos</creatorcontrib><creatorcontrib>Varla-Leftherioti, Marighoula</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of reproductive immunology (1989)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Paparistidis, Nikolaos</au><au>Papadopoulou, Chryssa</au><au>Chioti, Athanassia</au><au>Papaioannou, Demetrios</au><au>Tsekoura, Christina</au><au>Keramitsoglou, Theodora</au><au>Kontopoulou-Antonopoulou, Virginia</au><au>Agapitos, Emmanouel</au><au>Balafoutas, Christos</au><au>Varla-Leftherioti, Marighoula</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>How valuable is measurement of peripheral blood natural killer cells at the time of abortion?</atitle><jtitle>American journal of reproductive immunology (1989)</jtitle><addtitle>Am J Reprod Immunol</addtitle><date>2008-04</date><risdate>2008</risdate><volume>59</volume><issue>4</issue><spage>306</spage><epage>315</epage><pages>306-315</pages><issn>1046-7408</issn><abstract>Increased peripheral blood natural killer (NK) cells are associated to immune-mediated abortion, but their diagnostic value when measured at the time of miscarriage is unknown.
In women with therapeutic (A = 79) or elective (C = 34) pregnancy termination, the NK-cell percentage was measured before and 5 days after curettage. Additionally, immune-mediated lesions (scored 0-3) and CD56(+) and CD16(+) decidual NKs (scored 1-3) were detected on the abortion material.
Aborters differed from controls in histological scores (P = 0.000) and in NK percentage (>12%) only in the measurement 5 days after the operation (P = 0.038). In comparison to histological lesions, NK measurement was found to have sensitivity 70%, specificity 73.68%, positive prognostic value 89.39% and negative prognostic value 43.75%.
An Increased NK-cell percentage 5 days after the pregnancy termination could be a marker of immune aetiology of miscarriage, as the probability of an aborter with NK >12% to have an immune-mediated abortion is almost 90%.</abstract><cop>Denmark</cop><pmid>18294356</pmid><doi>10.1111/j.1600-0897.2007.00547.x</doi><tpages>10</tpages></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Abortion, Missed - blood Abortion, Missed - diagnosis Abortion, Missed - immunology Abortion, Missed - pathology Adult Antibodies, Monoclonal - immunology CD56 Antigen - analysis Chorionic Villi - immunology Chorionic Villi - pathology Female Humans Immunohistochemistry Keratins - analysis Keratins - immunology Killer Cells, Natural - cytology Killer Cells, Natural - immunology Lymphocyte Count Predictive Value of Tests Receptors, IgG - analysis Time Factors |
| title | How valuable is measurement of peripheral blood natural killer cells at the time of abortion? |
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