Renal Albumin Excretion: Twin Studies Identify Influences of Heredity, Environment, and Adrenergic Pathway Polymorphism

Albumin excretion marks early glomerular injury in hypertension. This study investigated heritability of albumin excretion in twin pairs and its genetic determination by adrenergic pathway polymorphism. Genetic associations used single nucleotide polymorphisms at adrenergic pathway loci spanning cat...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2007-05, Vol.49 (5), p.1015-1031
Hauptverfasser:	Rao, Fangwen, Wessel, Jennifer, Wen, Gen, Zhang, Lian, Rana, Brinda K, Kennedy, Brian P, Greenwood, Tiffany A, Salem, Rany M, Chen, Yuqing, Khandrika, Srikrishna, Hamilton, Bruce A, Smith, Douglas W, Holstein-Rathlou, Niels-Henrik, Ziegler, Michael G, Schork, Nicholas J, O’Connor, Daniel T
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged Aged, 80 and over Albuminuria - genetics Albuminuria - metabolism Albuminuria - physiopathology Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Catecholamines - biosynthesis Catecholamines - metabolism Clinical manifestations. Epidemiology. Investigative techniques. Etiology Environment Epistasis, Genetic Exocytosis Female Fundamental and applied biological sciences. Psychology Haplotypes Humans Kidney - metabolism Male Medical sciences Middle Aged Polymorphism, Genetic Receptors, Adrenergic - genetics Receptors, Dopamine D1 - genetics Signal Transduction - genetics Sympathetic Nervous System - physiopathology Vertebrates: urinary system
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