Syndecan-2 affects the basal and chemotherapy-induced apoptosis in osteosarcoma

Syndecans are transmembrane heparan sulfate proteoglycans controlling cell adhesion, migration, and proliferation. We previously showed that syndecan-2 is involved in the control of apoptosis in cultured osteosarcoma cells. These data led us to the hypothesis that syndecan-2 may play a role in the a...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2007-04, Vol.67 (8), p.3708-3715
Hauptverfasser:	OROSCO, Armelle, FROMIGUE, Olivia, BAZILLE, Céline, ENTZ-WERLE, Natacha, LEVILLAIN, Pierre, MARIE, Pierre J, MODROWSKI, Dominique
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic agents Antineoplastic Agents - pharmacology Apoptosis - drug effects Apoptosis - physiology Biological and medical sciences Bone Neoplasms - drug therapy Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Cell Line, Tumor Cell Movement - physiology Cisplatin - pharmacology Diseases of the osteoarticular system Doxorubicin - pharmacology Humans Immunohistochemistry Medical sciences Methotrexate - pharmacology Osteoblasts - metabolism Osteosarcoma - drug therapy Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology Pharmacology. Drug treatments RNA, Messenger - biosynthesis RNA, Messenger - genetics Syndecan-2 - biosynthesis Syndecan-2 - genetics Tumors Tumors of striated muscle and skeleton
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