The Arg16Gly variant of the beta2-adrenergic receptor predisposes to hypoglycemia unawareness in type 1 diabetes mellitus

Hypoglycemia unawareness has been linked to desensitization of the beta2-adrenergic receptor. Desensitization of the beta2-adrenergic receptor (ADRB2) is genetically determined by the Arg16Gly variant of this receptor. We tested the hypothesis that hypoglycemia unawareness is more common among patie...

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Veröffentlicht in:	Pharmacogenetics and genomics 2008-04, Vol.18 (4), p.369-372
Hauptverfasser:	Schouwenberg, Bas J, Veldman, Bart A, Spiering, Wilko, Coenen, Marieke J, Franke, Barbara, Tack, Cees J, de Galan, Bastiaan E, Smits, Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Arginine - genetics Awareness - physiology Child Child, Preschool Cohort Studies Diabetes Mellitus, Type 1 - complications Diabetes Mellitus, Type 1 - genetics Female Genotype Humans Hypoglycemia - diagnosis Hypoglycemia - genetics Male Polymorphism, Genetic Prospective Studies Receptors, Adrenergic, beta-2 - genetics Receptors, Adrenergic, beta-2 - metabolism
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