ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death

The apoptosis-inducing Fas ligand (FasL) is a type II transmembrane protein that is involved in the downregulation of immune reactions by activation-induced cell death (AICD) as well as in T cell-mediated cytotoxicity. Proteolytic cleavage leads to the generation of membrane-bound N-terminal fragmen...

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Veröffentlicht in:	Cell death and differentiation 2007-05, Vol.14 (5), p.1040-1049
Hauptverfasser:	Schulte, M, Reiss, K, Lettau, M, Maretzky, T, Ludwig, A, Hartmann, D, de Strooper, B, Janssen, O, Saftig, P
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM Proteins - antagonists & inhibitors ADAM Proteins - metabolism ADAM10 Protein Amyloid Precursor Protein Secretases - antagonists & inhibitors Amyloid Precursor Protein Secretases - metabolism Animals Cell death Cell Death - drug effects Enzyme Inhibitors - pharmacology Fas Ligand Protein - chemistry Fas Ligand Protein - metabolism Humans Jurkat Cells Membrane Proteins - antagonists & inhibitors Membrane Proteins - metabolism Mice Protein Processing, Post-Translational - drug effects Protein Transport - drug effects Recombinant Proteins - metabolism Solubility - drug effects T-Lymphocytes - cytology T-Lymphocytes - metabolism
Online-Zugang:	Volltext
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