Symptom overlap in patients with upper gastrointestinal complaints in the Canadian confirmatory acid suppression test (CAST) study: further psychometric validation of the reflux disease questionnaire
Summary Background The reflux disease questionnaire (RDQ) is a short, patient‐completed instrument. Aims To investigate the psychometric characteristics of the RDQ in patients with heartburn‐predominant (HB) and non‐heartburn predominant (NHB) dyspepsia. Methods HB (n = 388) and NHB (n = 733) patien...
Gespeichert in:
| Veröffentlicht in: | Alimentary pharmacology & therapeutics 2007-05, Vol.25 (9), p.1087-1097 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1097 |
|---|---|
| container_issue | 9 |
| container_start_page | 1087 |
| container_title | Alimentary pharmacology & therapeutics |
| container_volume | 25 |
| creator | VAN ZANTEN, S. V. ARMSTRONG, D. BARKUN, A. JUNGHARD, O. WHITE, R. J. WIKLUND, I. K. |
| description | Summary
Background The reflux disease questionnaire (RDQ) is a short, patient‐completed instrument.
Aims To investigate the psychometric characteristics of the RDQ in patients with heartburn‐predominant (HB) and non‐heartburn predominant (NHB) dyspepsia.
Methods HB (n = 388) and NHB (n = 733) patients were randomized to esomeprazole 40 mg daily or twice daily for 1 week, followed by 3 weeks of esomeprazole 40 mg daily.
Results High factor loadings (0.78–0.86) supported the ‘regurgitation’ dimension of the RDQ. Overlapping factor loadings in the ‘heartburn’ and ‘dyspepsia’ dimensions suggested symptom overlap. All dimensions demonstrated high internal consistency (Cronbach’s alpha: 0.79–0.90). Intra‐class correlation coefficients over 4 weeks were good (0.66–0.85). The RDQ showed good responsiveness over 4 weeks of treatment, with high effect sizes (≥0.80). Moderate or large symptom improvements were reported by 90% and 77% of HB and NHB patients, respectively, following treatment. Patients who responded to acid suppression also experienced symptom benefits in all RDQ dimensions.
Conclusions The RDQ is reliable, valid and responsive to change in HB and NHB patients. The symptom overlap is important but need not play a major role in determining treatment strategy as both patient groups benefited from proton pump inhibitor treatment. |
| doi_str_mv | 10.1111/j.1365-2036.2007.03271.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70392632</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>70392632</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4471-9fa3a4334875dd7f56cfa70d483e5a80c4a33524bcdbbf2b6ad1a32ebe93fbab3</originalsourceid><addsrcrecordid>eNqNkUuLFDEUhQtRnHb0L0g2ii6qzaOewiyaxhcMKEy7DrfysNNUJWWSmun6hf4tU92NszWbG7jfOffAyTJE8Jqk9-GwJqwqc4pZtaYY12vMaE3WxyfZ6t_iabbCtGpz2hB2lb0I4YAxrmpMn2dXpC5YWxK8yv7czcMY3YDcvfI9jMhYNEI0ysaAHkzco2kclUe_IETvjI0qRGOhR8INYw9mwZIk7hXaggVpwKaV1cYPEJ2fEQgjUUgmXoVgXEKTA3q33dzt3qMQJzl_RHryycCjMcxi7wYVvRHoHnojU5Ikcfp0wCvdT0ckTVAQFPo9LVmctWC8epk909AH9eoyr7Ofnz_ttl_z2-9fvm03t7koiprkrQYGBWNFU5dS1rqshIYay6JhqoQGiwIYK2nRCdl1mnYVSAKMqk61THfQsevs7dl39O4UgA8mCNX3YJWbAq8xa2nFaAKbMyi8CyFF56M3A_iZE8yXEvmBL13xpSu-lMhPJfJjkr6-3Ji6QclH4aW1BLy5ABAE9NqDFSY8ck1Vt5SxxN2cuQfTq_m_A_DNj93yY38BRYy_RQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>70392632</pqid></control><display><type>article</type><title>Symptom overlap in patients with upper gastrointestinal complaints in the Canadian confirmatory acid suppression test (CAST) study: further psychometric validation of the reflux disease questionnaire</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>VAN ZANTEN, S. V. ; ARMSTRONG, D. ; BARKUN, A. ; JUNGHARD, O. ; WHITE, R. J. ; WIKLUND, I. K.</creator><creatorcontrib>VAN ZANTEN, S. V. ; ARMSTRONG, D. ; BARKUN, A. ; JUNGHARD, O. ; WHITE, R. J. ; WIKLUND, I. K.</creatorcontrib><description>Summary
Background The reflux disease questionnaire (RDQ) is a short, patient‐completed instrument.
Aims To investigate the psychometric characteristics of the RDQ in patients with heartburn‐predominant (HB) and non‐heartburn predominant (NHB) dyspepsia.
Methods HB (n = 388) and NHB (n = 733) patients were randomized to esomeprazole 40 mg daily or twice daily for 1 week, followed by 3 weeks of esomeprazole 40 mg daily.
Results High factor loadings (0.78–0.86) supported the ‘regurgitation’ dimension of the RDQ. Overlapping factor loadings in the ‘heartburn’ and ‘dyspepsia’ dimensions suggested symptom overlap. All dimensions demonstrated high internal consistency (Cronbach’s alpha: 0.79–0.90). Intra‐class correlation coefficients over 4 weeks were good (0.66–0.85). The RDQ showed good responsiveness over 4 weeks of treatment, with high effect sizes (≥0.80). Moderate or large symptom improvements were reported by 90% and 77% of HB and NHB patients, respectively, following treatment. Patients who responded to acid suppression also experienced symptom benefits in all RDQ dimensions.
Conclusions The RDQ is reliable, valid and responsive to change in HB and NHB patients. The symptom overlap is important but need not play a major role in determining treatment strategy as both patient groups benefited from proton pump inhibitor treatment.</description><identifier>ISSN: 0269-2813</identifier><identifier>EISSN: 1365-2036</identifier><identifier>DOI: 10.1111/j.1365-2036.2007.03271.x</identifier><identifier>PMID: 17439510</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Anti-Ulcer Agents - therapeutic use ; Biological and medical sciences ; Canada ; Digestive system ; Dyspepsia - drug therapy ; Esomeprazole - therapeutic use ; Gastric Acid - secretion ; Gastroenterology. Liver. Pancreas. Abdomen ; Gastroesophageal Reflux - drug therapy ; Heartburn - drug therapy ; Humans ; Male ; Medical sciences ; Pharmacology. Drug treatments ; Psychometrics ; Surveys and Questionnaires - standards</subject><ispartof>Alimentary pharmacology & therapeutics, 2007-05, Vol.25 (9), p.1087-1097</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4471-9fa3a4334875dd7f56cfa70d483e5a80c4a33524bcdbbf2b6ad1a32ebe93fbab3</citedby><cites>FETCH-LOGICAL-c4471-9fa3a4334875dd7f56cfa70d483e5a80c4a33524bcdbbf2b6ad1a32ebe93fbab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2036.2007.03271.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2036.2007.03271.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18679233$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17439510$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>VAN ZANTEN, S. V.</creatorcontrib><creatorcontrib>ARMSTRONG, D.</creatorcontrib><creatorcontrib>BARKUN, A.</creatorcontrib><creatorcontrib>JUNGHARD, O.</creatorcontrib><creatorcontrib>WHITE, R. J.</creatorcontrib><creatorcontrib>WIKLUND, I. K.</creatorcontrib><title>Symptom overlap in patients with upper gastrointestinal complaints in the Canadian confirmatory acid suppression test (CAST) study: further psychometric validation of the reflux disease questionnaire</title><title>Alimentary pharmacology & therapeutics</title><addtitle>Aliment Pharmacol Ther</addtitle><description>Summary
Background The reflux disease questionnaire (RDQ) is a short, patient‐completed instrument.
Aims To investigate the psychometric characteristics of the RDQ in patients with heartburn‐predominant (HB) and non‐heartburn predominant (NHB) dyspepsia.
Methods HB (n = 388) and NHB (n = 733) patients were randomized to esomeprazole 40 mg daily or twice daily for 1 week, followed by 3 weeks of esomeprazole 40 mg daily.
Results High factor loadings (0.78–0.86) supported the ‘regurgitation’ dimension of the RDQ. Overlapping factor loadings in the ‘heartburn’ and ‘dyspepsia’ dimensions suggested symptom overlap. All dimensions demonstrated high internal consistency (Cronbach’s alpha: 0.79–0.90). Intra‐class correlation coefficients over 4 weeks were good (0.66–0.85). The RDQ showed good responsiveness over 4 weeks of treatment, with high effect sizes (≥0.80). Moderate or large symptom improvements were reported by 90% and 77% of HB and NHB patients, respectively, following treatment. Patients who responded to acid suppression also experienced symptom benefits in all RDQ dimensions.
Conclusions The RDQ is reliable, valid and responsive to change in HB and NHB patients. The symptom overlap is important but need not play a major role in determining treatment strategy as both patient groups benefited from proton pump inhibitor treatment.</description><subject>Adult</subject><subject>Anti-Ulcer Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Canada</subject><subject>Digestive system</subject><subject>Dyspepsia - drug therapy</subject><subject>Esomeprazole - therapeutic use</subject><subject>Gastric Acid - secretion</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Gastroesophageal Reflux - drug therapy</subject><subject>Heartburn - drug therapy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Psychometrics</subject><subject>Surveys and Questionnaires - standards</subject><issn>0269-2813</issn><issn>1365-2036</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkUuLFDEUhQtRnHb0L0g2ii6qzaOewiyaxhcMKEy7DrfysNNUJWWSmun6hf4tU92NszWbG7jfOffAyTJE8Jqk9-GwJqwqc4pZtaYY12vMaE3WxyfZ6t_iabbCtGpz2hB2lb0I4YAxrmpMn2dXpC5YWxK8yv7czcMY3YDcvfI9jMhYNEI0ysaAHkzco2kclUe_IETvjI0qRGOhR8INYw9mwZIk7hXaggVpwKaV1cYPEJ2fEQgjUUgmXoVgXEKTA3q33dzt3qMQJzl_RHryycCjMcxi7wYVvRHoHnojU5Ikcfp0wCvdT0ckTVAQFPo9LVmctWC8epk909AH9eoyr7Ofnz_ttl_z2-9fvm03t7koiprkrQYGBWNFU5dS1rqshIYay6JhqoQGiwIYK2nRCdl1mnYVSAKMqk61THfQsevs7dl39O4UgA8mCNX3YJWbAq8xa2nFaAKbMyi8CyFF56M3A_iZE8yXEvmBL13xpSu-lMhPJfJjkr6-3Ji6QclH4aW1BLy5ABAE9NqDFSY8ck1Vt5SxxN2cuQfTq_m_A_DNj93yY38BRYy_RQ</recordid><startdate>200705</startdate><enddate>200705</enddate><creator>VAN ZANTEN, S. V.</creator><creator>ARMSTRONG, D.</creator><creator>BARKUN, A.</creator><creator>JUNGHARD, O.</creator><creator>WHITE, R. J.</creator><creator>WIKLUND, I. K.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200705</creationdate><title>Symptom overlap in patients with upper gastrointestinal complaints in the Canadian confirmatory acid suppression test (CAST) study: further psychometric validation of the reflux disease questionnaire</title><author>VAN ZANTEN, S. V. ; ARMSTRONG, D. ; BARKUN, A. ; JUNGHARD, O. ; WHITE, R. J. ; WIKLUND, I. K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4471-9fa3a4334875dd7f56cfa70d483e5a80c4a33524bcdbbf2b6ad1a32ebe93fbab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Anti-Ulcer Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Canada</topic><topic>Digestive system</topic><topic>Dyspepsia - drug therapy</topic><topic>Esomeprazole - therapeutic use</topic><topic>Gastric Acid - secretion</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Gastroesophageal Reflux - drug therapy</topic><topic>Heartburn - drug therapy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Psychometrics</topic><topic>Surveys and Questionnaires - standards</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>VAN ZANTEN, S. V.</creatorcontrib><creatorcontrib>ARMSTRONG, D.</creatorcontrib><creatorcontrib>BARKUN, A.</creatorcontrib><creatorcontrib>JUNGHARD, O.</creatorcontrib><creatorcontrib>WHITE, R. J.</creatorcontrib><creatorcontrib>WIKLUND, I. K.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Alimentary pharmacology & therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>VAN ZANTEN, S. V.</au><au>ARMSTRONG, D.</au><au>BARKUN, A.</au><au>JUNGHARD, O.</au><au>WHITE, R. J.</au><au>WIKLUND, I. K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Symptom overlap in patients with upper gastrointestinal complaints in the Canadian confirmatory acid suppression test (CAST) study: further psychometric validation of the reflux disease questionnaire</atitle><jtitle>Alimentary pharmacology & therapeutics</jtitle><addtitle>Aliment Pharmacol Ther</addtitle><date>2007-05</date><risdate>2007</risdate><volume>25</volume><issue>9</issue><spage>1087</spage><epage>1097</epage><pages>1087-1097</pages><issn>0269-2813</issn><eissn>1365-2036</eissn><abstract>Summary
Background The reflux disease questionnaire (RDQ) is a short, patient‐completed instrument.
Aims To investigate the psychometric characteristics of the RDQ in patients with heartburn‐predominant (HB) and non‐heartburn predominant (NHB) dyspepsia.
Methods HB (n = 388) and NHB (n = 733) patients were randomized to esomeprazole 40 mg daily or twice daily for 1 week, followed by 3 weeks of esomeprazole 40 mg daily.
Results High factor loadings (0.78–0.86) supported the ‘regurgitation’ dimension of the RDQ. Overlapping factor loadings in the ‘heartburn’ and ‘dyspepsia’ dimensions suggested symptom overlap. All dimensions demonstrated high internal consistency (Cronbach’s alpha: 0.79–0.90). Intra‐class correlation coefficients over 4 weeks were good (0.66–0.85). The RDQ showed good responsiveness over 4 weeks of treatment, with high effect sizes (≥0.80). Moderate or large symptom improvements were reported by 90% and 77% of HB and NHB patients, respectively, following treatment. Patients who responded to acid suppression also experienced symptom benefits in all RDQ dimensions.
Conclusions The RDQ is reliable, valid and responsive to change in HB and NHB patients. The symptom overlap is important but need not play a major role in determining treatment strategy as both patient groups benefited from proton pump inhibitor treatment.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17439510</pmid><doi>10.1111/j.1365-2036.2007.03271.x</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0269-2813 |
| ispartof | Alimentary pharmacology & therapeutics, 2007-05, Vol.25 (9), p.1087-1097 |
| issn | 0269-2813 1365-2036 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70392632 |
| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult Anti-Ulcer Agents - therapeutic use Biological and medical sciences Canada Digestive system Dyspepsia - drug therapy Esomeprazole - therapeutic use Gastric Acid - secretion Gastroenterology. Liver. Pancreas. Abdomen Gastroesophageal Reflux - drug therapy Heartburn - drug therapy Humans Male Medical sciences Pharmacology. Drug treatments Psychometrics Surveys and Questionnaires - standards |
| title | Symptom overlap in patients with upper gastrointestinal complaints in the Canadian confirmatory acid suppression test (CAST) study: further psychometric validation of the reflux disease questionnaire |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-30T21%3A15%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Symptom%20overlap%20in%20patients%20with%20upper%20gastrointestinal%20complaints%20in%20the%20Canadian%20confirmatory%20acid%20suppression%20test%20(CAST)%20study:%20further%20psychometric%20validation%20of%20the%20reflux%20disease%20questionnaire&rft.jtitle=Alimentary%20pharmacology%20&%20therapeutics&rft.au=VAN%20ZANTEN,%20S.%20V.&rft.date=2007-05&rft.volume=25&rft.issue=9&rft.spage=1087&rft.epage=1097&rft.pages=1087-1097&rft.issn=0269-2813&rft.eissn=1365-2036&rft_id=info:doi/10.1111/j.1365-2036.2007.03271.x&rft_dat=%3Cproquest_cross%3E70392632%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=70392632&rft_id=info:pmid/17439510&rfr_iscdi=true |