Effect of exogenous catecholamines on tumor necrosis factor alpha, interleukin-6, interleukin-10 and beta-endorphin levels following severe trauma
Abstract Cytokines and endogenous opioids are mediators of the post traumatic inflammatory response. The aim of this study was to determine the effect of exogenous catecholamines on Tumor Necrosis Factor alpha (TNFa), interleukin-6 (IL-6), interleukin-10 (IL-10) and Beta(β)-endorphin levels in patie...
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| Veröffentlicht in: | Vascular pharmacology 2008-02, Vol.48 (2), p.85-91 |
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| creator | Batistaki, Chrysanthi Kostopanagiotou, Georgia Myrianthefs, Pavlos Dimas, Cleanthi Matsota, Paraskevi Pandazi, Aggeliki Baltopoulos, George |
| description | Abstract Cytokines and endogenous opioids are mediators of the post traumatic inflammatory response. The aim of this study was to determine the effect of exogenous catecholamines on Tumor Necrosis Factor alpha (TNFa), interleukin-6 (IL-6), interleukin-10 (IL-10) and Beta(β)-endorphin levels in patients with severe trauma, during the first 24 h after injury. Forty four traumatized patients with haemorrhage class III and IV were included in the study. Patients were divided in two groups: Group 1 (adrenergic, n = 22) and Group 2 (non adrenergic, n = 22), depending on the use of exogenous catecholamines. Blood samples were collected at 0, 2, 4 and 24 h time points. Baseline values were different between the two groups, but an altered pattern of release was observed for TNFa, IL-6, IL-10 and β-endorphin levels in patients treated with catecholamines. ICU stay was longer for the adrenergic group, while survival after 1 month was significantly lower. Findings support an altered pattern of cytokine release during the early phase after trauma, probably due to catecholamine presence. |
| doi_str_mv | 10.1016/j.vph.2007.12.003 |
| format | Article |
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The aim of this study was to determine the effect of exogenous catecholamines on Tumor Necrosis Factor alpha (TNFa), interleukin-6 (IL-6), interleukin-10 (IL-10) and Beta(β)-endorphin levels in patients with severe trauma, during the first 24 h after injury. Forty four traumatized patients with haemorrhage class III and IV were included in the study. Patients were divided in two groups: Group 1 (adrenergic, n = 22) and Group 2 (non adrenergic, n = 22), depending on the use of exogenous catecholamines. Blood samples were collected at 0, 2, 4 and 24 h time points. Baseline values were different between the two groups, but an altered pattern of release was observed for TNFa, IL-6, IL-10 and β-endorphin levels in patients treated with catecholamines. ICU stay was longer for the adrenergic group, while survival after 1 month was significantly lower. Findings support an altered pattern of cytokine release during the early phase after trauma, probably due to catecholamine presence.</description><identifier>ISSN: 1537-1891</identifier><identifier>EISSN: 1879-3649</identifier><identifier>DOI: 10.1016/j.vph.2007.12.003</identifier><identifier>PMID: 18234565</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; beta-Endorphin - blood ; Cardiovascular ; Catecholamines ; Catecholamines - administration & dosage ; Cytokines ; Female ; Hospital Mortality ; Humans ; Infusions, Intravenous ; Intensive Care Units ; Interleukin-10 - blood ; Interleukin-6 - blood ; Length of Stay ; Male ; Middle Aged ; Prospective Studies ; Severity of Illness Index ; Shock ; Shock, Hemorrhagic - blood ; Shock, Hemorrhagic - drug therapy ; Shock, Hemorrhagic - etiology ; Shock, Hemorrhagic - mortality ; Systemic Inflammatory Response Syndrome - blood ; Systemic Inflammatory Response Syndrome - drug therapy ; Systemic Inflammatory Response Syndrome - etiology ; Systemic Inflammatory Response Syndrome - mortality ; Time Factors ; Trauma ; Treatment Outcome ; Tumor Necrosis Factor-alpha - blood ; Wounds and Injuries - blood ; Wounds and Injuries - complications ; Wounds and Injuries - drug therapy ; Wounds and Injuries - mortality ; β-endorphin</subject><ispartof>Vascular pharmacology, 2008-02, Vol.48 (2), p.85-91</ispartof><rights>Elsevier Inc.</rights><rights>2007 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c472t-5dbef2949a97af1d629713b98a4109bc9f6a0d1a0bc0539e6f1534eed4ddc8973</citedby><cites>FETCH-LOGICAL-c472t-5dbef2949a97af1d629713b98a4109bc9f6a0d1a0bc0539e6f1534eed4ddc8973</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.vph.2007.12.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18234565$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Batistaki, Chrysanthi</creatorcontrib><creatorcontrib>Kostopanagiotou, Georgia</creatorcontrib><creatorcontrib>Myrianthefs, Pavlos</creatorcontrib><creatorcontrib>Dimas, Cleanthi</creatorcontrib><creatorcontrib>Matsota, Paraskevi</creatorcontrib><creatorcontrib>Pandazi, Aggeliki</creatorcontrib><creatorcontrib>Baltopoulos, George</creatorcontrib><title>Effect of exogenous catecholamines on tumor necrosis factor alpha, interleukin-6, interleukin-10 and beta-endorphin levels following severe trauma</title><title>Vascular pharmacology</title><addtitle>Vascul Pharmacol</addtitle><description>Abstract Cytokines and endogenous opioids are mediators of the post traumatic inflammatory response. The aim of this study was to determine the effect of exogenous catecholamines on Tumor Necrosis Factor alpha (TNFa), interleukin-6 (IL-6), interleukin-10 (IL-10) and Beta(β)-endorphin levels in patients with severe trauma, during the first 24 h after injury. Forty four traumatized patients with haemorrhage class III and IV were included in the study. Patients were divided in two groups: Group 1 (adrenergic, n = 22) and Group 2 (non adrenergic, n = 22), depending on the use of exogenous catecholamines. Blood samples were collected at 0, 2, 4 and 24 h time points. Baseline values were different between the two groups, but an altered pattern of release was observed for TNFa, IL-6, IL-10 and β-endorphin levels in patients treated with catecholamines. ICU stay was longer for the adrenergic group, while survival after 1 month was significantly lower. Findings support an altered pattern of cytokine release during the early phase after trauma, probably due to catecholamine presence.</description><subject>Adult</subject><subject>Aged</subject><subject>beta-Endorphin - blood</subject><subject>Cardiovascular</subject><subject>Catecholamines</subject><subject>Catecholamines - administration & dosage</subject><subject>Cytokines</subject><subject>Female</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Infusions, Intravenous</subject><subject>Intensive Care Units</subject><subject>Interleukin-10 - blood</subject><subject>Interleukin-6 - blood</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Severity of Illness Index</subject><subject>Shock</subject><subject>Shock, Hemorrhagic - blood</subject><subject>Shock, Hemorrhagic - drug therapy</subject><subject>Shock, Hemorrhagic - etiology</subject><subject>Shock, Hemorrhagic - mortality</subject><subject>Systemic Inflammatory Response Syndrome - blood</subject><subject>Systemic Inflammatory Response Syndrome - drug therapy</subject><subject>Systemic Inflammatory Response Syndrome - etiology</subject><subject>Systemic Inflammatory Response Syndrome - mortality</subject><subject>Time Factors</subject><subject>Trauma</subject><subject>Treatment Outcome</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Wounds and Injuries - blood</subject><subject>Wounds and Injuries - complications</subject><subject>Wounds and Injuries - drug therapy</subject><subject>Wounds and Injuries - mortality</subject><subject>β-endorphin</subject><issn>1537-1891</issn><issn>1879-3649</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9Uk2L1TAULaI4H_oD3EhWrmzN7UfaIAgyjKMw4EJdhzS5mZc3aVKT9un8DX-xKe-B6MLVvTeccyDnnKJ4AbQCCuzNvjrMu6qmtK-grihtHhXnMPS8bFjLH-e9a_oSBg5nxUVKe0phGBh_WpzBUDdtx7rz4te1MagWEgzBn-EOfVgTUXJBtQtOTtZjIsGTZZ1CJB5VDMkmYqRa8i3dvJOvifULRofrvfUl-_sESqTXZMRFluh1iPPOeuLwgC6rBOfCD-vvSMoPEckS5TrJZ8UTI13C56d5WXz7cP316mN5-_nm09X721K1fb2UnR7R1LzlkvfSgGY176EZ-SBboHxU3DBJNUg6Kto1HJnJdrSIutVaDbxvLotXR905hu8rpkVMNil0TnrMLoieNryGjmUgHIHb71NEI-ZoJxkfBFCxBSH2IgchtiAE1CIHkTkvT-LrOKH-wzg5nwFvj4DsBB4sRpGURa9Q25gDETrY_8q_-4etnPVWSXePD5j2YY0-eydApEwQX7YmbEWgfS4BY0PzGyNysTY</recordid><startdate>20080201</startdate><enddate>20080201</enddate><creator>Batistaki, Chrysanthi</creator><creator>Kostopanagiotou, Georgia</creator><creator>Myrianthefs, Pavlos</creator><creator>Dimas, Cleanthi</creator><creator>Matsota, Paraskevi</creator><creator>Pandazi, Aggeliki</creator><creator>Baltopoulos, George</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20080201</creationdate><title>Effect of exogenous catecholamines on tumor necrosis factor alpha, interleukin-6, interleukin-10 and beta-endorphin levels following severe trauma</title><author>Batistaki, Chrysanthi ; Kostopanagiotou, Georgia ; Myrianthefs, Pavlos ; Dimas, Cleanthi ; Matsota, Paraskevi ; Pandazi, Aggeliki ; Baltopoulos, George</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c472t-5dbef2949a97af1d629713b98a4109bc9f6a0d1a0bc0539e6f1534eed4ddc8973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>beta-Endorphin - blood</topic><topic>Cardiovascular</topic><topic>Catecholamines</topic><topic>Catecholamines - administration & dosage</topic><topic>Cytokines</topic><topic>Female</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Infusions, Intravenous</topic><topic>Intensive Care Units</topic><topic>Interleukin-10 - blood</topic><topic>Interleukin-6 - blood</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Severity of Illness Index</topic><topic>Shock</topic><topic>Shock, Hemorrhagic - blood</topic><topic>Shock, Hemorrhagic - drug therapy</topic><topic>Shock, Hemorrhagic - etiology</topic><topic>Shock, Hemorrhagic - mortality</topic><topic>Systemic Inflammatory Response Syndrome - blood</topic><topic>Systemic Inflammatory Response Syndrome - drug therapy</topic><topic>Systemic Inflammatory Response Syndrome - etiology</topic><topic>Systemic Inflammatory Response Syndrome - mortality</topic><topic>Time Factors</topic><topic>Trauma</topic><topic>Treatment Outcome</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Wounds and Injuries - blood</topic><topic>Wounds and Injuries - complications</topic><topic>Wounds and Injuries - drug therapy</topic><topic>Wounds and Injuries - mortality</topic><topic>β-endorphin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Batistaki, Chrysanthi</creatorcontrib><creatorcontrib>Kostopanagiotou, Georgia</creatorcontrib><creatorcontrib>Myrianthefs, Pavlos</creatorcontrib><creatorcontrib>Dimas, Cleanthi</creatorcontrib><creatorcontrib>Matsota, Paraskevi</creatorcontrib><creatorcontrib>Pandazi, Aggeliki</creatorcontrib><creatorcontrib>Baltopoulos, George</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Vascular pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Batistaki, Chrysanthi</au><au>Kostopanagiotou, Georgia</au><au>Myrianthefs, Pavlos</au><au>Dimas, Cleanthi</au><au>Matsota, Paraskevi</au><au>Pandazi, Aggeliki</au><au>Baltopoulos, George</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of exogenous catecholamines on tumor necrosis factor alpha, interleukin-6, interleukin-10 and beta-endorphin levels following severe trauma</atitle><jtitle>Vascular pharmacology</jtitle><addtitle>Vascul Pharmacol</addtitle><date>2008-02-01</date><risdate>2008</risdate><volume>48</volume><issue>2</issue><spage>85</spage><epage>91</epage><pages>85-91</pages><issn>1537-1891</issn><eissn>1879-3649</eissn><abstract>Abstract Cytokines and endogenous opioids are mediators of the post traumatic inflammatory response. The aim of this study was to determine the effect of exogenous catecholamines on Tumor Necrosis Factor alpha (TNFa), interleukin-6 (IL-6), interleukin-10 (IL-10) and Beta(β)-endorphin levels in patients with severe trauma, during the first 24 h after injury. Forty four traumatized patients with haemorrhage class III and IV were included in the study. Patients were divided in two groups: Group 1 (adrenergic, n = 22) and Group 2 (non adrenergic, n = 22), depending on the use of exogenous catecholamines. Blood samples were collected at 0, 2, 4 and 24 h time points. Baseline values were different between the two groups, but an altered pattern of release was observed for TNFa, IL-6, IL-10 and β-endorphin levels in patients treated with catecholamines. ICU stay was longer for the adrenergic group, while survival after 1 month was significantly lower. Findings support an altered pattern of cytokine release during the early phase after trauma, probably due to catecholamine presence.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>18234565</pmid><doi>10.1016/j.vph.2007.12.003</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Vascular pharmacology, 2008-02, Vol.48 (2), p.85-91 |
| issn | 1537-1891 1879-3649 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Aged beta-Endorphin - blood Cardiovascular Catecholamines Catecholamines - administration & dosage Cytokines Female Hospital Mortality Humans Infusions, Intravenous Intensive Care Units Interleukin-10 - blood Interleukin-6 - blood Length of Stay Male Middle Aged Prospective Studies Severity of Illness Index Shock Shock, Hemorrhagic - blood Shock, Hemorrhagic - drug therapy Shock, Hemorrhagic - etiology Shock, Hemorrhagic - mortality Systemic Inflammatory Response Syndrome - blood Systemic Inflammatory Response Syndrome - drug therapy Systemic Inflammatory Response Syndrome - etiology Systemic Inflammatory Response Syndrome - mortality Time Factors Trauma Treatment Outcome Tumor Necrosis Factor-alpha - blood Wounds and Injuries - blood Wounds and Injuries - complications Wounds and Injuries - drug therapy Wounds and Injuries - mortality β-endorphin |
| title | Effect of exogenous catecholamines on tumor necrosis factor alpha, interleukin-6, interleukin-10 and beta-endorphin levels following severe trauma |
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