Prognostic Impact of Sarcomatous Change of Hepatocellular Carcinoma in Patients Undergoing Liver Resection and Liver Transplantation
Sarcomatous change has been rarely observed in hepatocellular carcinoma (HCC), but it is usually associated with very aggressive tumor behavior and widespread metastasis. To assess the impact of sarcomatous changes, we analyzed the outcomes of 15 patients with sarcomatous HCC after resection ( n = ...
Gespeichert in:
| Veröffentlicht in: | Journal of gastrointestinal surgery 2008-04, Vol.12 (4), p.718-724 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 724 |
|---|---|
| container_issue | 4 |
| container_start_page | 718 |
| container_title | Journal of gastrointestinal surgery |
| container_volume | 12 |
| creator | Hwang, Shin Lee, Sung-Gyu Lee, Young-Joo Ahn, Chul-Soo Kim, Ki-Hun Park, Kwang-Min Moon, Ki-Myung Moon, Deok-Bog Ha, Tae-Yong Yu, Eun-Sil Choi, Ga-Won |
| description | Sarcomatous change has been rarely observed in hepatocellular carcinoma (HCC), but it is usually associated with very aggressive tumor behavior and widespread metastasis. To assess the impact of sarcomatous changes, we analyzed the outcomes of 15 patients with sarcomatous HCC after resection (
n
= 11) or liver transplantation (LT) (
n
= 4). No imaging findings characteristic of sarcomatous changes were observed. According to modified pathological tumor-node metastasis staging, the HCC lesions were classified as stage II in five patients, stage III in six, stage IVa2 in two, and stage IVb in one. The Milan criteria were met in 7 of 15 patients, including 3 of 4 in the LT group. R0 resection was achieved in 9 of 11 resected patients, and their 3-year overall and disease-free survival rates were both 18.2%. In the LT group, 3-year overall and disease-free survival rates were 37.5 and 25%, respectively. In patients within the Milan criteria, 2-year overall survival rate was 25% after resection and 33% after LT, showing no prognostic difference. Extrahepatic metastasis as initial recurrence was detected in 80% after resection and 66.7% after LT. In conclusion, we found that the prognosis of patients with sarcomatous HCC was very unfavorable after either resection or LT and that, except for liver biopsy, no diagnostic method could distinguish between sarcomatous and ordinary HCC. Vigorous postoperative systemic surveillance may be helpful for timely detection and treatment of localized metastases. |
| doi_str_mv | 10.1007/s11605-007-0393-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_70391067</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2789666591</sourcerecordid><originalsourceid>FETCH-LOGICAL-c436t-cb1a1661709fb68d99649b6e481b9822cb6238ca43457c245e63d23302300eff3</originalsourceid><addsrcrecordid>eNp1kV-L1TAQxYMo7h_9AL5IQPCtOpO0afMol9VduOCiu-BbSNP0mqVNapIKvvvBTbkXXASfcpj55SQzh5BXCO8QoH2fEAU0VZEVcMmr9gk5x67lVS2YeFo0SKxY03w7IxcpPQBgC9g9J2fYSimRsXPy-zaGgw8pO0Nv5kWbTMNIv-powqxzWBPdfdf-YLfqtV1KydhpWicd6a5AzheMOk9vdXbW50Tv_WDjITh_oHv300b6xSZrsgueaj-candR-7RM2me9dV6QZ6Oekn15Oi_J_ceru911tf_86Wb3YV-ZmotcmR41ClGGkGMvukFKUcte2LrDXnaMmV4w3hld87ppDasbK_jAOAfGAew48kvy9ui7xPBjtSmr2aVtHu1tGVW1ZYsIoi3gm3_Ah7BGX_6mEMveeAcAhcIjZWJIKdpRLdHNOv5SCGoLSB0DUpvcAlKb8-uT89rPdvh745RIAdgRSKVVFh8fPf1f1z-jupwE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1112238000</pqid></control><display><type>article</type><title>Prognostic Impact of Sarcomatous Change of Hepatocellular Carcinoma in Patients Undergoing Liver Resection and Liver Transplantation</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Hwang, Shin ; Lee, Sung-Gyu ; Lee, Young-Joo ; Ahn, Chul-Soo ; Kim, Ki-Hun ; Park, Kwang-Min ; Moon, Ki-Myung ; Moon, Deok-Bog ; Ha, Tae-Yong ; Yu, Eun-Sil ; Choi, Ga-Won</creator><creatorcontrib>Hwang, Shin ; Lee, Sung-Gyu ; Lee, Young-Joo ; Ahn, Chul-Soo ; Kim, Ki-Hun ; Park, Kwang-Min ; Moon, Ki-Myung ; Moon, Deok-Bog ; Ha, Tae-Yong ; Yu, Eun-Sil ; Choi, Ga-Won</creatorcontrib><description>Sarcomatous change has been rarely observed in hepatocellular carcinoma (HCC), but it is usually associated with very aggressive tumor behavior and widespread metastasis. To assess the impact of sarcomatous changes, we analyzed the outcomes of 15 patients with sarcomatous HCC after resection (
n
= 11) or liver transplantation (LT) (
n
= 4). No imaging findings characteristic of sarcomatous changes were observed. According to modified pathological tumor-node metastasis staging, the HCC lesions were classified as stage II in five patients, stage III in six, stage IVa2 in two, and stage IVb in one. The Milan criteria were met in 7 of 15 patients, including 3 of 4 in the LT group. R0 resection was achieved in 9 of 11 resected patients, and their 3-year overall and disease-free survival rates were both 18.2%. In the LT group, 3-year overall and disease-free survival rates were 37.5 and 25%, respectively. In patients within the Milan criteria, 2-year overall survival rate was 25% after resection and 33% after LT, showing no prognostic difference. Extrahepatic metastasis as initial recurrence was detected in 80% after resection and 66.7% after LT. In conclusion, we found that the prognosis of patients with sarcomatous HCC was very unfavorable after either resection or LT and that, except for liver biopsy, no diagnostic method could distinguish between sarcomatous and ordinary HCC. Vigorous postoperative systemic surveillance may be helpful for timely detection and treatment of localized metastases.</description><identifier>ISSN: 1091-255X</identifier><identifier>EISSN: 1873-4626</identifier><identifier>DOI: 10.1007/s11605-007-0393-7</identifier><identifier>PMID: 17999122</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Aged ; Carcinoma, Hepatocellular - mortality ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Disease-Free Survival ; Female ; Gastroenterology ; Hepatectomy ; Humans ; Liver cancer ; Liver cirrhosis ; Liver Neoplasms - mortality ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Liver Transplantation ; Lymphatic Metastasis - pathology ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Middle Aged ; Original Article ; Prognosis ; Sarcoma - pathology ; Surgery ; Treatment Outcome ; Tumors</subject><ispartof>Journal of gastrointestinal surgery, 2008-04, Vol.12 (4), p.718-724</ispartof><rights>The Society for Surgery of the Alimentary Tract 2007</rights><rights>The Society for Surgery of the Alimentary Tract 2008</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-cb1a1661709fb68d99649b6e481b9822cb6238ca43457c245e63d23302300eff3</citedby><cites>FETCH-LOGICAL-c436t-cb1a1661709fb68d99649b6e481b9822cb6238ca43457c245e63d23302300eff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11605-007-0393-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11605-007-0393-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17999122$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hwang, Shin</creatorcontrib><creatorcontrib>Lee, Sung-Gyu</creatorcontrib><creatorcontrib>Lee, Young-Joo</creatorcontrib><creatorcontrib>Ahn, Chul-Soo</creatorcontrib><creatorcontrib>Kim, Ki-Hun</creatorcontrib><creatorcontrib>Park, Kwang-Min</creatorcontrib><creatorcontrib>Moon, Ki-Myung</creatorcontrib><creatorcontrib>Moon, Deok-Bog</creatorcontrib><creatorcontrib>Ha, Tae-Yong</creatorcontrib><creatorcontrib>Yu, Eun-Sil</creatorcontrib><creatorcontrib>Choi, Ga-Won</creatorcontrib><title>Prognostic Impact of Sarcomatous Change of Hepatocellular Carcinoma in Patients Undergoing Liver Resection and Liver Transplantation</title><title>Journal of gastrointestinal surgery</title><addtitle>J Gastrointest Surg</addtitle><addtitle>J Gastrointest Surg</addtitle><description>Sarcomatous change has been rarely observed in hepatocellular carcinoma (HCC), but it is usually associated with very aggressive tumor behavior and widespread metastasis. To assess the impact of sarcomatous changes, we analyzed the outcomes of 15 patients with sarcomatous HCC after resection (
n
= 11) or liver transplantation (LT) (
n
= 4). No imaging findings characteristic of sarcomatous changes were observed. According to modified pathological tumor-node metastasis staging, the HCC lesions were classified as stage II in five patients, stage III in six, stage IVa2 in two, and stage IVb in one. The Milan criteria were met in 7 of 15 patients, including 3 of 4 in the LT group. R0 resection was achieved in 9 of 11 resected patients, and their 3-year overall and disease-free survival rates were both 18.2%. In the LT group, 3-year overall and disease-free survival rates were 37.5 and 25%, respectively. In patients within the Milan criteria, 2-year overall survival rate was 25% after resection and 33% after LT, showing no prognostic difference. Extrahepatic metastasis as initial recurrence was detected in 80% after resection and 66.7% after LT. In conclusion, we found that the prognosis of patients with sarcomatous HCC was very unfavorable after either resection or LT and that, except for liver biopsy, no diagnostic method could distinguish between sarcomatous and ordinary HCC. Vigorous postoperative systemic surveillance may be helpful for timely detection and treatment of localized metastases.</description><subject>Aged</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Hepatectomy</subject><subject>Humans</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Liver Transplantation</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Male</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Original Article</subject><subject>Prognosis</subject><subject>Sarcoma - pathology</subject><subject>Surgery</subject><subject>Treatment Outcome</subject><subject>Tumors</subject><issn>1091-255X</issn><issn>1873-4626</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kV-L1TAQxYMo7h_9AL5IQPCtOpO0afMol9VduOCiu-BbSNP0mqVNapIKvvvBTbkXXASfcpj55SQzh5BXCO8QoH2fEAU0VZEVcMmr9gk5x67lVS2YeFo0SKxY03w7IxcpPQBgC9g9J2fYSimRsXPy-zaGgw8pO0Nv5kWbTMNIv-powqxzWBPdfdf-YLfqtV1KydhpWicd6a5AzheMOk9vdXbW50Tv_WDjITh_oHv300b6xSZrsgueaj-candR-7RM2me9dV6QZ6Oekn15Oi_J_ceru911tf_86Wb3YV-ZmotcmR41ClGGkGMvukFKUcte2LrDXnaMmV4w3hld87ppDasbK_jAOAfGAew48kvy9ui7xPBjtSmr2aVtHu1tGVW1ZYsIoi3gm3_Ah7BGX_6mEMveeAcAhcIjZWJIKdpRLdHNOv5SCGoLSB0DUpvcAlKb8-uT89rPdvh745RIAdgRSKVVFh8fPf1f1z-jupwE</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Hwang, Shin</creator><creator>Lee, Sung-Gyu</creator><creator>Lee, Young-Joo</creator><creator>Ahn, Chul-Soo</creator><creator>Kim, Ki-Hun</creator><creator>Park, Kwang-Min</creator><creator>Moon, Ki-Myung</creator><creator>Moon, Deok-Bog</creator><creator>Ha, Tae-Yong</creator><creator>Yu, Eun-Sil</creator><creator>Choi, Ga-Won</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Prognostic Impact of Sarcomatous Change of Hepatocellular Carcinoma in Patients Undergoing Liver Resection and Liver Transplantation</title><author>Hwang, Shin ; Lee, Sung-Gyu ; Lee, Young-Joo ; Ahn, Chul-Soo ; Kim, Ki-Hun ; Park, Kwang-Min ; Moon, Ki-Myung ; Moon, Deok-Bog ; Ha, Tae-Yong ; Yu, Eun-Sil ; Choi, Ga-Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-cb1a1661709fb68d99649b6e481b9822cb6238ca43457c245e63d23302300eff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>Hepatectomy</topic><topic>Humans</topic><topic>Liver cancer</topic><topic>Liver cirrhosis</topic><topic>Liver Neoplasms - mortality</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Liver Transplantation</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Male</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Original Article</topic><topic>Prognosis</topic><topic>Sarcoma - pathology</topic><topic>Surgery</topic><topic>Treatment Outcome</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hwang, Shin</creatorcontrib><creatorcontrib>Lee, Sung-Gyu</creatorcontrib><creatorcontrib>Lee, Young-Joo</creatorcontrib><creatorcontrib>Ahn, Chul-Soo</creatorcontrib><creatorcontrib>Kim, Ki-Hun</creatorcontrib><creatorcontrib>Park, Kwang-Min</creatorcontrib><creatorcontrib>Moon, Ki-Myung</creatorcontrib><creatorcontrib>Moon, Deok-Bog</creatorcontrib><creatorcontrib>Ha, Tae-Yong</creatorcontrib><creatorcontrib>Yu, Eun-Sil</creatorcontrib><creatorcontrib>Choi, Ga-Won</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of gastrointestinal surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hwang, Shin</au><au>Lee, Sung-Gyu</au><au>Lee, Young-Joo</au><au>Ahn, Chul-Soo</au><au>Kim, Ki-Hun</au><au>Park, Kwang-Min</au><au>Moon, Ki-Myung</au><au>Moon, Deok-Bog</au><au>Ha, Tae-Yong</au><au>Yu, Eun-Sil</au><au>Choi, Ga-Won</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Impact of Sarcomatous Change of Hepatocellular Carcinoma in Patients Undergoing Liver Resection and Liver Transplantation</atitle><jtitle>Journal of gastrointestinal surgery</jtitle><stitle>J Gastrointest Surg</stitle><addtitle>J Gastrointest Surg</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>12</volume><issue>4</issue><spage>718</spage><epage>724</epage><pages>718-724</pages><issn>1091-255X</issn><eissn>1873-4626</eissn><abstract>Sarcomatous change has been rarely observed in hepatocellular carcinoma (HCC), but it is usually associated with very aggressive tumor behavior and widespread metastasis. To assess the impact of sarcomatous changes, we analyzed the outcomes of 15 patients with sarcomatous HCC after resection (
n
= 11) or liver transplantation (LT) (
n
= 4). No imaging findings characteristic of sarcomatous changes were observed. According to modified pathological tumor-node metastasis staging, the HCC lesions were classified as stage II in five patients, stage III in six, stage IVa2 in two, and stage IVb in one. The Milan criteria were met in 7 of 15 patients, including 3 of 4 in the LT group. R0 resection was achieved in 9 of 11 resected patients, and their 3-year overall and disease-free survival rates were both 18.2%. In the LT group, 3-year overall and disease-free survival rates were 37.5 and 25%, respectively. In patients within the Milan criteria, 2-year overall survival rate was 25% after resection and 33% after LT, showing no prognostic difference. Extrahepatic metastasis as initial recurrence was detected in 80% after resection and 66.7% after LT. In conclusion, we found that the prognosis of patients with sarcomatous HCC was very unfavorable after either resection or LT and that, except for liver biopsy, no diagnostic method could distinguish between sarcomatous and ordinary HCC. Vigorous postoperative systemic surveillance may be helpful for timely detection and treatment of localized metastases.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>17999122</pmid><doi>10.1007/s11605-007-0393-7</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1091-255X |
| ispartof | Journal of gastrointestinal surgery, 2008-04, Vol.12 (4), p.718-724 |
| issn | 1091-255X 1873-4626 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70391067 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Aged Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Disease-Free Survival Female Gastroenterology Hepatectomy Humans Liver cancer Liver cirrhosis Liver Neoplasms - mortality Liver Neoplasms - pathology Liver Neoplasms - surgery Liver Transplantation Lymphatic Metastasis - pathology Male Medical research Medicine Medicine & Public Health Middle Aged Original Article Prognosis Sarcoma - pathology Surgery Treatment Outcome Tumors |
| title | Prognostic Impact of Sarcomatous Change of Hepatocellular Carcinoma in Patients Undergoing Liver Resection and Liver Transplantation |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-15T03%3A03%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20Impact%20of%20Sarcomatous%20Change%20of%20Hepatocellular%20Carcinoma%20in%20Patients%20Undergoing%20Liver%20Resection%20and%20Liver%20Transplantation&rft.jtitle=Journal%20of%20gastrointestinal%20surgery&rft.au=Hwang,%20Shin&rft.date=2008-04-01&rft.volume=12&rft.issue=4&rft.spage=718&rft.epage=724&rft.pages=718-724&rft.issn=1091-255X&rft.eissn=1873-4626&rft_id=info:doi/10.1007/s11605-007-0393-7&rft_dat=%3Cproquest_cross%3E2789666591%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1112238000&rft_id=info:pmid/17999122&rfr_iscdi=true |