Biological Properties of New Derivatives of Daunorubicin
In the search for new derivatives of daunorubicin with high activity and/or the ability to overcome the drug resistance barrier of cancer cells, some new analogs of amidino-daunorubicin, containing the chiral substituent in the formamidine group (-N=CH-N
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| Veröffentlicht in: | In vivo (Athens) 2007-03, Vol.21 (2), p.413-416 |
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| container_title | In vivo (Athens) |
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| creator | Wasowska-Lukawska, Malgorzata Wietrzyk, Joanna Opolski, Adam Oszczapowicz, Janusz Oszczapowicz, Irena |
| description | In the search for new derivatives of daunorubicin with high activity and/or the ability to overcome the drug resistance barrier
of cancer cells, some new analogs of amidino-daunorubicin, containing the chiral substituent in the formamidine group (-N=CH-N |
| format | Article |
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of cancer cells, some new analogs of amidino-daunorubicin, containing the chiral substituent in the formamidine group (-N=CH-N<)
at the C-3â² position of daunosamine moiety, have been synthesized. In order to estimate the influence of the configuration
of the chiral group on the biological properties of the new derivatives of daunorubicin, three chiral amines, namely 1-cyclohexylethylamine,
1-phenylethylamine and N-methyl-1-phenylethylamine, both R and S isomers and their racemates, were used. These new compounds
were tested for their cytotoxic activity in vitro against the cells of A549, SW707, T47D and HCV29T cancer lines. The resistance
index (RI) values were obtained using the cells of the sensitive LoVo, MES-SA, HL-60 human cancer cell lines, as well as their
resistant sublines (LoVo/Dx, MES-SA/DX5 and HL-60/MX2, respectively). All obtained derivatives appeared to be able to overcome
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of cancer cells, some new analogs of amidino-daunorubicin, containing the chiral substituent in the formamidine group (-N=CH-N<)
at the C-3â² position of daunosamine moiety, have been synthesized. In order to estimate the influence of the configuration
of the chiral group on the biological properties of the new derivatives of daunorubicin, three chiral amines, namely 1-cyclohexylethylamine,
1-phenylethylamine and N-methyl-1-phenylethylamine, both R and S isomers and their racemates, were used. These new compounds
were tested for their cytotoxic activity in vitro against the cells of A549, SW707, T47D and HCV29T cancer lines. The resistance
index (RI) values were obtained using the cells of the sensitive LoVo, MES-SA, HL-60 human cancer cell lines, as well as their
resistant sublines (LoVo/Dx, MES-SA/DX5 and HL-60/MX2, respectively). All obtained derivatives appeared to be able to overcome
the drug resistance barrier of cancer cells.</description><subject>Antibiotics, Antineoplastic - pharmacology</subject><subject>Cell Division - drug effects</subject><subject>Cell Line, Tumor</subject><subject>Daunorubicin - analogs & derivatives</subject><subject>Daunorubicin - pharmacology</subject><subject>HL-60 Cells</subject><subject>Humans</subject><issn>0258-851X</issn><issn>1791-7549</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1z89LwzAcBfAgipvTf0F6EG-FpEma5Kibv2CoBwVvIW2_2SLpUpO2w__ewubpwePDg3eC5kQokgvO1Cma44LLXHLyNUMXKX1jXAqMi3M0I4LRkqtyjuS9Cz5sXG189h5DB7F3kLJgs1fYZyuIbjS9Gw_Vygy7EIfK1W53ic6s8QmujrlAn48PH8vnfP329LK8W-fbgso-t7y2qrFcSIo5MYoJIIpLS7kiqha4YlAKoSStwFgGQlbYSDoVwIy1jaULdHvY7WL4GSD1unWpBu_NDsKQtMBUYSnZBK-PcKhaaHQXXWvir_7_OoGbA9i6zXbvIujUGu8nTrUbC6ILzQilfxjQXUk</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>Wasowska-Lukawska, Malgorzata</creator><creator>Wietrzyk, Joanna</creator><creator>Opolski, Adam</creator><creator>Oszczapowicz, Janusz</creator><creator>Oszczapowicz, Irena</creator><general>International Institute of Anticancer Research</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20070301</creationdate><title>Biological Properties of New Derivatives of Daunorubicin</title><author>Wasowska-Lukawska, Malgorzata ; Wietrzyk, Joanna ; Opolski, Adam ; Oszczapowicz, Janusz ; Oszczapowicz, Irena</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h238t-f5cf9df5783051a947e1958f35919c70b4e677983beaf4e78b0a83798e4affdf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Antibiotics, Antineoplastic - pharmacology</topic><topic>Cell Division - drug effects</topic><topic>Cell Line, Tumor</topic><topic>Daunorubicin - analogs & derivatives</topic><topic>Daunorubicin - pharmacology</topic><topic>HL-60 Cells</topic><topic>Humans</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wasowska-Lukawska, Malgorzata</creatorcontrib><creatorcontrib>Wietrzyk, Joanna</creatorcontrib><creatorcontrib>Opolski, Adam</creatorcontrib><creatorcontrib>Oszczapowicz, Janusz</creatorcontrib><creatorcontrib>Oszczapowicz, Irena</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>In vivo (Athens)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wasowska-Lukawska, Malgorzata</au><au>Wietrzyk, Joanna</au><au>Opolski, Adam</au><au>Oszczapowicz, Janusz</au><au>Oszczapowicz, Irena</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biological Properties of New Derivatives of Daunorubicin</atitle><jtitle>In vivo (Athens)</jtitle><addtitle>In Vivo</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>21</volume><issue>2</issue><spage>413</spage><epage>416</epage><pages>413-416</pages><issn>0258-851X</issn><eissn>1791-7549</eissn><abstract>In the search for new derivatives of daunorubicin with high activity and/or the ability to overcome the drug resistance barrier
of cancer cells, some new analogs of amidino-daunorubicin, containing the chiral substituent in the formamidine group (-N=CH-N<)
at the C-3â² position of daunosamine moiety, have been synthesized. In order to estimate the influence of the configuration
of the chiral group on the biological properties of the new derivatives of daunorubicin, three chiral amines, namely 1-cyclohexylethylamine,
1-phenylethylamine and N-methyl-1-phenylethylamine, both R and S isomers and their racemates, were used. These new compounds
were tested for their cytotoxic activity in vitro against the cells of A549, SW707, T47D and HCV29T cancer lines. The resistance
index (RI) values were obtained using the cells of the sensitive LoVo, MES-SA, HL-60 human cancer cell lines, as well as their
resistant sublines (LoVo/Dx, MES-SA/DX5 and HL-60/MX2, respectively). All obtained derivatives appeared to be able to overcome
the drug resistance barrier of cancer cells.</abstract><cop>Greece</cop><pub>International Institute of Anticancer Research</pub><pmid>17436596</pmid><tpages>4</tpages></addata></record> |
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| ispartof | In vivo (Athens), 2007-03, Vol.21 (2), p.413-416 |
| issn | 0258-851X 1791-7549 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Antibiotics, Antineoplastic - pharmacology Cell Division - drug effects Cell Line, Tumor Daunorubicin - analogs & derivatives Daunorubicin - pharmacology HL-60 Cells Humans |
| title | Biological Properties of New Derivatives of Daunorubicin |
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