Anti-proliferative effect of clitocine from the mushroom Leucopaxillus giganteus on human cervical cancer HeLa cells by inducing apoptosis

Abstract Clitocine, a natural biologically active substance isolated from the mushroom Leucopaxillus giganteus , possesses several bioactivities including antitumor. Here, for the first time, we studied the molecular mechanism of clitocine-induced apoptosis in human cervical cancer cells (HeLa). Cli...

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Veröffentlicht in:	Cancer letters 2008-04, Vol.262 (2), p.190-200
Hauptverfasser:	Ren, Gang, Zhao, Yun-peng, Yang, Lu, Fu, Cheng-Xin
Format:	Artikel
Sprache:	eng
Schlagworte:	Agaricales - chemistry Apoptosis Apoptosis - drug effects Caspases - metabolism Caspases activation Caspases, Initiator - pharmacology Cell Proliferation - drug effects Cell Shape - drug effects Cervical cancer Chemotherapy Clitocine Cytotoxicity DNA Fragmentation - drug effects Female HeLa cells HeLa Cells - drug effects Hematology, Oncology and Palliative Medicine Humans Kinases Medical prognosis Pyrimidine Nucleosides - pharmacology Radiation therapy Software Spectrum analysis Studies Uterine Cervical Neoplasms - drug therapy
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