Polymorphism of XRCC1 and the frequency of mutation in codon 249 of the p53 gene in hepatocellular carcinoma among guangxi population, China

In hepatocellular carcinoma (HCC), hotspot mutation in codon 249 of the p53 gene has been associated with exposure to aflatoxin B1 (AFB1). While the polymorphism of DNA repair gene X‐ray repair cross‐complementary group 1 (XRCC1) Arg399Gln may be related with AFB1‐DNA adducts and gene mutations. Fiv...

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Veröffentlicht in:	Molecular carcinogenesis 2008-04, Vol.47 (4), p.295-300
Hauptverfasser:	Long, Xi Dai, Ma, Yun, Huang, Hong Dong, Yao, Jin Guang, Qu, De Ying, Lu, Yun Long
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult AFB1 Aged Aged, 80 and over Carcinoma, Hepatocellular - genetics China Codon DNA-Binding Proteins - genetics Female Gene Frequency Genes, p53 HCC hotspot mutation Humans Liver Neoplasms - genetics Male Middle Aged Mutation p53 polymorphism Polymorphism, Genetic Tumor Suppressor Protein p53 - genetics X-ray Repair Cross Complementing Protein 1 XRCC1
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