Histone Acetylation in Keratinocytes Enables Control of the Expression of Cathelicidin and CD14 by 1,25-Dihydroxyvitamin D3

Hormonally active vitamin D3—1,25-dihydroxyvitamin D3 (1,25D3)—acts as a signaling molecule in cutaneous immunity by increasing pattern recognition through Toll-like receptor-2 (TLR2), and increasing the expression and function of antimicrobial peptides. Here we show that the actions of 1,25D3 on ke...

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Veröffentlicht in:	Journal of investigative dermatology 2008-04, Vol.128 (4), p.816-824
Hauptverfasser:	Schauber, Jürgen, Oda, Yuko, Büchau, Amanda S., Yun, Qian-Chun, Steinmeyer, Andreas, Zügel, Ulrich, Bikle, Daniel D., Gallo, Richard L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Antimicrobial Cationic Peptides - genetics Butyrates - pharmacology Calcitriol - pharmacology Calcitriol - physiology Cell Line Enzyme Inhibitors - pharmacology Epigenesis, Genetic Histone Acetyltransferases - analysis Histone Acetyltransferases - antagonists & inhibitors Histone Acetyltransferases - metabolism Histones - metabolism Humans Hydroxamic Acids - pharmacology Immunity, Innate - genetics Keratinocytes - drug effects Keratinocytes - immunology Keratinocytes - microbiology Lipopolysaccharide Receptors - genetics Nuclear Receptor Coactivator 3 Receptors, Calcitriol - antagonists & inhibitors RNA, Small Interfering - pharmacology Skin - drug effects Skin - immunology Skin - microbiology Staphylococcus aureus - immunology Toll-Like Receptor 2 - agonists Trans-Activators - analysis Trans-Activators - antagonists & inhibitors Trans-Activators - metabolism
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