Increased Connective Tissue Growth Factor Relative to Brain Natriuretic Peptide as a Determinant of Myocardial Fibrosis

Excessive fibrosis contributes to an increase in left ventricular stiffness. The goal of the present study was to investigate the role of connective tissue growth factor (CCN2/CTGF), a profibrotic cytokine of the CCN (Cyr61, CTGF, and Nov) family, and its functional interactions with brain natriuret...

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Veröffentlicht in:	Hypertension (Dallas, Tex. 1979) Tex. 1979), 2007-05, Vol.49 (5), p.1120-1127
Hauptverfasser:	Koitabashi, Norimichi, Arai, Masashi, Kogure, Shinya, Niwano, Kazuo, Watanabe, Atai, Aoki, Yasuhiro, Maeno, Toshitaka, Nishida, Takashi, Kubota, Satoshi, Takigawa, Masaharu, Kurabayashi, Masahiko
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Arterial hypertension. Arterial hypotension Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cardiomegaly - complications Cardiomegaly - genetics Cardiomegaly - metabolism Cardiomegaly - physiopathology Cardiotonic agents Cardiovascular system Cells, Cultured Clinical manifestations. Epidemiology. Investigative techniques. Etiology Connective Tissue Growth Factor Elasticity Endomyocardial Fibrosis - metabolism Endomyocardial Fibrosis - pathology Fibrosis Gene Expression Humans Immediate-Early Proteins - antagonists & inhibitors Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Intercellular Signaling Peptides and Proteins - genetics Intercellular Signaling Peptides and Proteins - metabolism Male Medical sciences Myocardium - metabolism Myocardium - pathology Myocytes, Cardiac - metabolism Natriuretic Peptide, Brain - genetics Natriuretic Peptide, Brain - metabolism Natriuretic Peptide, Brain - pharmacology Nephroblastoma Overexpressed Protein Pharmacology. Drug treatments Rats Rats, Wistar RNA, Messenger - metabolism Stimulation, Chemical Stroke Volume Transcription, Genetic Ventricular Dysfunction - etiology
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