Instabilities in multiserotype disease models with antibody-dependent enhancement
This paper investigates the complex dynamics induced by antibody-dependent enhancement (ADE) in multiserotype disease models. ADE is the increase in viral growth rate in the presence of immunity due to a previous infection of a different serotype. The increased viral growth rate is thought to increa...
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| Veröffentlicht in: | Journal of theoretical biology 2007-05, Vol.246 (1), p.18-27 |
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| container_title | Journal of theoretical biology |
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| creator | Billings, Lora Schwartz, Ira B. Shaw, Leah B. McCrary, Marie Burke, Donald S. Cummings, Derek A.T. |
| description | This paper investigates the complex dynamics induced by antibody-dependent enhancement (ADE) in multiserotype disease models. ADE is the increase in viral growth rate in the presence of immunity due to a previous infection of a different serotype. The increased viral growth rate is thought to increase the infectivity of the secondary infectious class. In our models, ADE induces the onset of oscillations without external forcing. The oscillations in the infectious classes represent outbreaks of the disease. In this paper, we derive approximations of the ADE parameter needed to induce oscillations and analyze the associated bifurcations that separate the types of oscillations. We then investigate the stability of these dynamics by adding stochastic perturbations to the model. We also present a preliminary analysis of the effect of a single serotype vaccination in the model. |
| doi_str_mv | 10.1016/j.jtbi.2006.12.023 |
| format | Article |
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ADE is the increase in viral growth rate in the presence of immunity due to a previous infection of a different serotype. The increased viral growth rate is thought to increase the infectivity of the secondary infectious class. In our models, ADE induces the onset of oscillations without external forcing. The oscillations in the infectious classes represent outbreaks of the disease. In this paper, we derive approximations of the ADE parameter needed to induce oscillations and analyze the associated bifurcations that separate the types of oscillations. We then investigate the stability of these dynamics by adding stochastic perturbations to the model. 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| subjects | Animals Antibodies, Viral - immunology Antibody-Dependent Enhancement Dengue Disease Outbreaks Epidemics Humans Models, Immunological Multiserotype Nonlinear Dynamics Vaccination Vaccine Virulence Virus Diseases - immunology Virus Diseases - prevention & control Viruses - immunology |
| title | Instabilities in multiserotype disease models with antibody-dependent enhancement |
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