Structural and functional recovery elicited by combined putrescine and aminoguanidine treatment after aspirative lesion of the fimbria-fornix and overlying cortex in the adult rat
Damage to the adult CNS often causes permanent deficits. Based on a lesion model of septohippocampal pathway aspiration in the rat, we attempted to promote neuronal cell survival and post‐traumatic recovery by using a pharmalogical treatment combining aminoguanidine and putrescine (AGP). The functio...
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| Veröffentlicht in: | The European journal of neuroscience 2007-04, Vol.25 (7), p.1949-1960 |
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| container_issue | 7 |
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| container_title | The European journal of neuroscience |
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| creator | Muller, Christophe Herberth, Heike Cosquer, Brigitte Kelche, Christian Cassel, Jean-Christophe Schimchowitsch, Sarah |
| description | Damage to the adult CNS often causes permanent deficits. Based on a lesion model of septohippocampal pathway aspiration in the rat, we attempted to promote neuronal cell survival and post‐traumatic recovery by using a pharmalogical treatment combining aminoguanidine and putrescine (AGP). The functional recovery was followed over 15 weeks before morphological analysis. AGP treatment produced a persistent attenuation (∼ 50%) of the lesion‐induced hyperactivity, a reduction (∼ 60%) in the sensorimotor impairments and an improved performance in the water‐maze task which did not, however, rely upon improved memory capabilities. AGP weakened the lesion‐induced decrease in ChAT‐positive neurons in the medial septum and the extent of thalamic retrograde necrosis (by ∼ 30% in each case) and resulted in a partial cholinergic reinnervation of the dentate gyrus. These promising results support the idea that coadministration of putrescine and aminoguanidine might become a potent way to foster structural and functional recovery (or compensation) in the adult mammalian CNS after injury. |
| doi_str_mv | 10.1111/j.1460-9568.2007.05474.x |
| format | Article |
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Based on a lesion model of septohippocampal pathway aspiration in the rat, we attempted to promote neuronal cell survival and post‐traumatic recovery by using a pharmalogical treatment combining aminoguanidine and putrescine (AGP). The functional recovery was followed over 15 weeks before morphological analysis. AGP treatment produced a persistent attenuation (∼ 50%) of the lesion‐induced hyperactivity, a reduction (∼ 60%) in the sensorimotor impairments and an improved performance in the water‐maze task which did not, however, rely upon improved memory capabilities. AGP weakened the lesion‐induced decrease in ChAT‐positive neurons in the medial septum and the extent of thalamic retrograde necrosis (by ∼ 30% in each case) and resulted in a partial cholinergic reinnervation of the dentate gyrus. 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Based on a lesion model of septohippocampal pathway aspiration in the rat, we attempted to promote neuronal cell survival and post‐traumatic recovery by using a pharmalogical treatment combining aminoguanidine and putrescine (AGP). The functional recovery was followed over 15 weeks before morphological analysis. AGP treatment produced a persistent attenuation (∼ 50%) of the lesion‐induced hyperactivity, a reduction (∼ 60%) in the sensorimotor impairments and an improved performance in the water‐maze task which did not, however, rely upon improved memory capabilities. AGP weakened the lesion‐induced decrease in ChAT‐positive neurons in the medial septum and the extent of thalamic retrograde necrosis (by ∼ 30% in each case) and resulted in a partial cholinergic reinnervation of the dentate gyrus. 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Herberth, Heike ; Cosquer, Brigitte ; Kelche, Christian ; Cassel, Jean-Christophe ; Schimchowitsch, Sarah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4364-576196455a82d954f98c45b55bfee7247301c7dd61a5bfeb3be7470dc1652b373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>brain injury</topic><topic>cAMP cascade</topic><topic>Cerebral Cortex - anatomy & histology</topic><topic>Cerebral Cortex - drug effects</topic><topic>Cerebral Cortex - pathology</topic><topic>Enzyme Inhibitors - pharmacology</topic><topic>Fornix, Brain - anatomy & histology</topic><topic>Fornix, Brain - drug effects</topic><topic>Fornix, Brain - pathology</topic><topic>Guanidines - pharmacology</topic><topic>iNOS inhibitor</topic><topic>Male</topic><topic>mammalian central nervous system</topic><topic>Maze Learning - drug effects</topic><topic>Motor Activity - drug effects</topic><topic>neuroprotection</topic><topic>Putrescine - pharmacology</topic><topic>Rats</topic><topic>Rats, Long-Evans</topic><topic>Recovery of Function - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Muller, Christophe</creatorcontrib><creatorcontrib>Herberth, Heike</creatorcontrib><creatorcontrib>Cosquer, Brigitte</creatorcontrib><creatorcontrib>Kelche, Christian</creatorcontrib><creatorcontrib>Cassel, Jean-Christophe</creatorcontrib><creatorcontrib>Schimchowitsch, Sarah</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The European journal of neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Muller, Christophe</au><au>Herberth, Heike</au><au>Cosquer, Brigitte</au><au>Kelche, Christian</au><au>Cassel, Jean-Christophe</au><au>Schimchowitsch, Sarah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Structural and functional recovery elicited by combined putrescine and aminoguanidine treatment after aspirative lesion of the fimbria-fornix and overlying cortex in the adult rat</atitle><jtitle>The European journal of neuroscience</jtitle><addtitle>Eur J Neurosci</addtitle><date>2007-04</date><risdate>2007</risdate><volume>25</volume><issue>7</issue><spage>1949</spage><epage>1960</epage><pages>1949-1960</pages><issn>0953-816X</issn><eissn>1460-9568</eissn><abstract>Damage to the adult CNS often causes permanent deficits. Based on a lesion model of septohippocampal pathway aspiration in the rat, we attempted to promote neuronal cell survival and post‐traumatic recovery by using a pharmalogical treatment combining aminoguanidine and putrescine (AGP). The functional recovery was followed over 15 weeks before morphological analysis. AGP treatment produced a persistent attenuation (∼ 50%) of the lesion‐induced hyperactivity, a reduction (∼ 60%) in the sensorimotor impairments and an improved performance in the water‐maze task which did not, however, rely upon improved memory capabilities. AGP weakened the lesion‐induced decrease in ChAT‐positive neurons in the medial septum and the extent of thalamic retrograde necrosis (by ∼ 30% in each case) and resulted in a partial cholinergic reinnervation of the dentate gyrus. These promising results support the idea that coadministration of putrescine and aminoguanidine might become a potent way to foster structural and functional recovery (or compensation) in the adult mammalian CNS after injury.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17439484</pmid><doi>10.1111/j.1460-9568.2007.05474.x</doi><tpages>12</tpages></addata></record> |
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| subjects | Animals brain injury cAMP cascade Cerebral Cortex - anatomy & histology Cerebral Cortex - drug effects Cerebral Cortex - pathology Enzyme Inhibitors - pharmacology Fornix, Brain - anatomy & histology Fornix, Brain - drug effects Fornix, Brain - pathology Guanidines - pharmacology iNOS inhibitor Male mammalian central nervous system Maze Learning - drug effects Motor Activity - drug effects neuroprotection Putrescine - pharmacology Rats Rats, Long-Evans Recovery of Function - drug effects |
| title | Structural and functional recovery elicited by combined putrescine and aminoguanidine treatment after aspirative lesion of the fimbria-fornix and overlying cortex in the adult rat |
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