Involvement of Fibroblast Growth Factor Receptor 2 Isoform Switching in Mammary Oncogenesis

We identified the IIIb C2 epithelial cell–specific splice variant of fibroblast growth factor receptor 2 (FGFR2 IIIb C2) receptor tyrosine kinase in a screen for activated oncogenes expressed in T-47D human breast carcinoma cells. We found FGFR2 IIIb C2 expression in breast carcinoma cell lines and,...

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Veröffentlicht in:	Molecular cancer research 2008-03, Vol.6 (3), p.435-445
Hauptverfasser:	Cha, Jiyoung Y, Lambert, Que T, Reuther, Gary W, Der, Channing J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alternative Splicing Amino Acid Sequence Breast Neoplasms - genetics Breast Neoplasms - pathology Breast Neoplasms - physiopathology Carcinoma - genetics Carcinoma - pathology Carcinoma - physiopathology Cell Division Cell Line, Tumor Female gene splicing Genetic Variation Humans keratinocyte growth factor Molecular Sequence Data Protein Conformation Protein Isoforms - physiology Ras receptor tyrosine kinase Receptor, Fibroblast Growth Factor, Type 2 - chemistry Receptor, Fibroblast Growth Factor, Type 2 - genetics
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