Antiretroviral Therapy for HIV-1—Infected Children in Haiti

Antiretroviral Therapy for HIV-1—Infected Children in Haiti

Background. Data are limited about the effectiveness of pediatric antiretroviral therapy (ART) in low-income countries. Methods. We report the outcomes of consecutively treating 236 human immunodeficiency virus type 1 (HIV-1)—infected treatment-naive children with triple ART in Port-au-Prince, Haiti...

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Veröffentlicht in:The Journal of infectious diseases 2007-05, Vol.195 (10), p.1411-1418
Hauptverfasser: George, Eric, Noël, Francine, Bois, Gyrlande, Cassagnol, Rachelle, Estavien, Louise, De Matteis Rouzier, Patricia, Verdier, Rose I., Johnson, Warren D., Pape, Jean W., Fitzgerald, Daniel W., Wright, Peter F.
Format: Artikel
Sprache:eng
Schlagworte:
Acquired Immunodeficiency Syndrome - drug therapy
Acquired Immunodeficiency Syndrome - epidemiology
Acquired Immunodeficiency Syndrome - mortality
AIDS
Antiretroviral Therapy, Highly Active
Antiretrovirals
Assisted reproductive techniques
Child
Child health services
Childrens art
Follow-Up Studies
Haiti - epidemiology
HIV
HIV 1
HIV/AIDS
Human immunodeficiency virus 1
Humans
Pediatrics
Poverty
RNA
Survival Analysis
T lymphocytes
Treatment Outcome
Viral Load
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Zusammenfassung:Background. Data are limited about the effectiveness of pediatric antiretroviral therapy (ART) in low-income countries. Methods. We report the outcomes of consecutively treating 236 human immunodeficiency virus type 1 (HIV-1)—infected treatment-naive children with triple ART in Port-au-Prince, Haiti, between 1 May 2003 and 30 April 2006. Results. Kaplan-Meier survival analysis at follow-up demonstrated that 191 children (81%) remained in care, 21 (9%) were dead, and 24 (10%) were lost to follow-up. Independent baseline predictors of mortality were age
ISSN:0022-1899
1537-6613
DOI:10.1086/514823