Fibrotic disorders in the eye: Targets of gene therapy

Fibrotic diseases, e.g., cutaneous and corneal scarring, keloids, and liver and lung fibrosis, etc., are characterized by appearance of myofibroblasts, the key player of the fibrogenic reaction, and excess accumulation of extracellular matrix with resultant tissue contraction and impaired functions....

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Veröffentlicht in:	Progress in retinal and eye research 2008-03, Vol.27 (2), p.177-196
Hauptverfasser:	Saika, Shizuya, Yamanaka, Osamu, Sumioka, Takayoshi, Miyamoto, Takeshi, Miyazaki, Ken-ichi, Okada, Yuka, Kitano, Ai, Shirai, Kumi, Tanaka, Sai-ichi, Ikeda, Kazuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Conjunctiva - pathology Cornea - pathology Epithelial–mesenchymal transition Eye Eye Diseases - pathology Eye Diseases - therapy Fibroblasts - pathology Fibrosis - therapy Gene transfer Gene Transfer Techniques Genetic Therapy - methods Humans Lens Capsule, Crystalline - pathology Mitogen-Activated Protein Kinases - genetics Myofibroblast Retina - pathology Signal transduction Skin - pathology Smad Smad Proteins - genetics Tissue fibrosis Transforming Growth Factor beta - genetics Transforming growth factor β
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