Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav 1.5

The cardiac sodium channel Nav 1.5 is essential for the physiological function of the heart and contributes to lethal cardiac arrhythmias and sudden death when mutated. Here, we report that MOG1, a small protein that is highly conserved from yeast to humans, is a central component of the channel com...

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Veröffentlicht in:	The Journal of biological chemistry 2008-03, Vol.283 (11), p.6968-6978
Hauptverfasser:	Wu, Ling, Yong, Sandro L, Fan, Chun, Ni, Ying, Yoo, Shin, Zhang, Teng, Zhang, Xianqin, Obejero-Paz, Carlos A, Rho, Hyun-Jin, Ke, Tie, Szafranski, Przemyslaw, Jones, Stephen W, Chen, Qiuyun, Wang, Qing Kenneth
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Electrophysiology - methods Gene Expression Regulation Glutathione Transferase - metabolism Heart - physiology Humans Mice Mice, Inbred CBA Models, Biological Muscle Proteins - chemistry NAV1.5 Voltage-Gated Sodium Channel ran GTP-Binding Protein - chemistry ran GTP-Binding Protein - physiology Sodium Channels - chemistry Two-Hybrid System Techniques
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