Molecular mechanism involved in the transport of a prodrug dopamine glycosyl conjugate

We have previously demonstrated that dopamine conjugation to glucose allows it to induce therapeutic effects against Parkinson's disease after intravenous administration. In this paper we demonstrate that, unlike dopamine, the prodrug glu-dopamine is a transportable substrate of glucose transpo...

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Veröffentlicht in:	International journal of pharmaceutics 2007-05, Vol.336 (1), p.133-139
Hauptverfasser:	Dalpiaz, A., Filosa, R., de Caprariis, P., Conte, G., Bortolotti, F., Biondi, C., Scatturin, A., Prasad, P.D., Pavan, B.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-O-Methylglucose - metabolism Biological and medical sciences Biological Transport Cells, Cultured Chromatography, High Pressure Liquid Dopamine Dopamine - chemistry Dopamine - metabolism Dopamine - pharmacokinetics Drug targeting Epithelial Cells - chemistry Epithelial Cells - drug effects Epithelial Cells - metabolism General pharmacology Glucose Glucose - chemistry Glucose - metabolism Glucose - pharmacokinetics Glucose Transport Proteins, Facilitative - metabolism Glucose transporters HRPE cells Humans Kinetics Medical sciences Molecular Structure Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Pigment Epithelium of Eye - cytology Prodrugs - metabolism Prodrugs - pharmacokinetics
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