Evolutionary Formation of New Centromeres in Macaque
A systematic fluorescence in situ hybridization comparison of macaque and human synteny organization disclosed five additional macaque evolutionary new centromeres (ENCs) for a total of nine ENCs. To understand the dynamics of ENC formation and progression, we compared the ENC of macaque chromosome...
Gespeichert in:
| Veröffentlicht in: | Science (American Association for the Advancement of Science) 2007-04, Vol.316 (5822), p.243-246 |
|---|---|
| Hauptverfasser: | , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 246 |
|---|---|
| container_issue | 5822 |
| container_start_page | 243 |
| container_title | Science (American Association for the Advancement of Science) |
| container_volume | 316 |
| creator | Ventura, Mario Antonacci, Francesca Cardone, Maria Francesca Stanyon, Roscoe D'Addabbo, Pietro Cellamare, Angelo Sprague, L. James Eichler, Evan E Archidiacono, Nicoletta Rocchi, Mariano |
| description | A systematic fluorescence in situ hybridization comparison of macaque and human synteny organization disclosed five additional macaque evolutionary new centromeres (ENCs) for a total of nine ENCs. To understand the dynamics of ENC formation and progression, we compared the ENC of macaque chromosome 4 with the human orthologous region, at 6q24.3, that conserves the ancestral genomic organization. A 250-kilobase segment was extensively duplicated around the macaque centromere. These duplications were strictly intrachromosomal. Our results suggest that novel centromeres may trigger only local duplication activity and that the absence of genes in the seeding region may have been important in ENC maintenance and progression. |
| doi_str_mv | 10.1126/science.1140615 |
| format | Article |
| fullrecord | <record><control><sourceid>jstor_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_70382410</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><jstor_id>20036004</jstor_id><sourcerecordid>20036004</sourcerecordid><originalsourceid>FETCH-LOGICAL-c509t-2b5f845e5bae7705e086ed91c6fb3ed33365b11d52766cb21d1f2b39543f26ff3</originalsourceid><addsrcrecordid>eNqFkLtPwzAQhy0EgvKYmYBMbKF3duwkI6paQOIxQGfLSc4oqInBTkH897hqBCOTdfp9vsfH2CnCFSJX01C31NcUiwwUyh02QShlWnIQu2wCIFRaQC4P2GEIbwAxK8U-O8A8E4g5Tlg2_3Sr9dC63vjvZOF8ZzZF4mzySF_JjPrBu448haTtkwdTm481HbM9a1aBTsb3iC0X85fZbXr_dHM3u75PawnlkPJK2iKTJCtDeQ6SoFDUlFgrWwlqhBBKVoiN5LlSdcWxQcsrUcpMWK6sFUfsctv33bs4Ngy6a0NNq5Xpya2DzkEUPEP4F-SQQdwki-B0C9beheDJ6nffdvF0jaA3RvVoVI9G44_zsfW66qj540eFETjbAm9hcP435xv5AJuRF9vcGqfNq2-DXj5zQAEQz5a8ED99G4RI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>20408454</pqid></control><display><type>article</type><title>Evolutionary Formation of New Centromeres in Macaque</title><source>American Association for the Advancement of Science</source><source>Jstor Complete Legacy</source><source>MEDLINE</source><creator>Ventura, Mario ; Antonacci, Francesca ; Cardone, Maria Francesca ; Stanyon, Roscoe ; D'Addabbo, Pietro ; Cellamare, Angelo ; Sprague, L. James ; Eichler, Evan E ; Archidiacono, Nicoletta ; Rocchi, Mariano</creator><creatorcontrib>Ventura, Mario ; Antonacci, Francesca ; Cardone, Maria Francesca ; Stanyon, Roscoe ; D'Addabbo, Pietro ; Cellamare, Angelo ; Sprague, L. James ; Eichler, Evan E ; Archidiacono, Nicoletta ; Rocchi, Mariano</creatorcontrib><description>A systematic fluorescence in situ hybridization comparison of macaque and human synteny organization disclosed five additional macaque evolutionary new centromeres (ENCs) for a total of nine ENCs. To understand the dynamics of ENC formation and progression, we compared the ENC of macaque chromosome 4 with the human orthologous region, at 6q24.3, that conserves the ancestral genomic organization. A 250-kilobase segment was extensively duplicated around the macaque centromere. These duplications were strictly intrachromosomal. Our results suggest that novel centromeres may trigger only local duplication activity and that the absence of genes in the seeding region may have been important in ENC maintenance and progression.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.1140615</identifier><identifier>PMID: 17431171</identifier><language>eng</language><publisher>United States: American Association for the Advancement of Science</publisher><subject>Animals ; Base Sequence ; Centromere ; Centromeres ; Chromosomes ; Chromosomes, Human, Pair 6 ; DNA ; Evolution ; Evolution, Molecular ; Gene Duplication ; Genes ; Genomes ; Genomics ; Human chromosomes ; Humans ; Macaca ; Macaca mulatta - genetics ; Molecular Sequence Data ; Seeding ; Sequence Tagged Sites ; Sequencing ; Synteny</subject><ispartof>Science (American Association for the Advancement of Science), 2007-04, Vol.316 (5822), p.243-246</ispartof><rights>Copyright 2006 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c509t-2b5f845e5bae7705e086ed91c6fb3ed33365b11d52766cb21d1f2b39543f26ff3</citedby><cites>FETCH-LOGICAL-c509t-2b5f845e5bae7705e086ed91c6fb3ed33365b11d52766cb21d1f2b39543f26ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/20036004$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/20036004$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17431171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ventura, Mario</creatorcontrib><creatorcontrib>Antonacci, Francesca</creatorcontrib><creatorcontrib>Cardone, Maria Francesca</creatorcontrib><creatorcontrib>Stanyon, Roscoe</creatorcontrib><creatorcontrib>D'Addabbo, Pietro</creatorcontrib><creatorcontrib>Cellamare, Angelo</creatorcontrib><creatorcontrib>Sprague, L. James</creatorcontrib><creatorcontrib>Eichler, Evan E</creatorcontrib><creatorcontrib>Archidiacono, Nicoletta</creatorcontrib><creatorcontrib>Rocchi, Mariano</creatorcontrib><title>Evolutionary Formation of New Centromeres in Macaque</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>A systematic fluorescence in situ hybridization comparison of macaque and human synteny organization disclosed five additional macaque evolutionary new centromeres (ENCs) for a total of nine ENCs. To understand the dynamics of ENC formation and progression, we compared the ENC of macaque chromosome 4 with the human orthologous region, at 6q24.3, that conserves the ancestral genomic organization. A 250-kilobase segment was extensively duplicated around the macaque centromere. These duplications were strictly intrachromosomal. Our results suggest that novel centromeres may trigger only local duplication activity and that the absence of genes in the seeding region may have been important in ENC maintenance and progression.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Centromere</subject><subject>Centromeres</subject><subject>Chromosomes</subject><subject>Chromosomes, Human, Pair 6</subject><subject>DNA</subject><subject>Evolution</subject><subject>Evolution, Molecular</subject><subject>Gene Duplication</subject><subject>Genes</subject><subject>Genomes</subject><subject>Genomics</subject><subject>Human chromosomes</subject><subject>Humans</subject><subject>Macaca</subject><subject>Macaca mulatta - genetics</subject><subject>Molecular Sequence Data</subject><subject>Seeding</subject><subject>Sequence Tagged Sites</subject><subject>Sequencing</subject><subject>Synteny</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkLtPwzAQhy0EgvKYmYBMbKF3duwkI6paQOIxQGfLSc4oqInBTkH897hqBCOTdfp9vsfH2CnCFSJX01C31NcUiwwUyh02QShlWnIQu2wCIFRaQC4P2GEIbwAxK8U-O8A8E4g5Tlg2_3Sr9dC63vjvZOF8ZzZF4mzySF_JjPrBu448haTtkwdTm481HbM9a1aBTsb3iC0X85fZbXr_dHM3u75PawnlkPJK2iKTJCtDeQ6SoFDUlFgrWwlqhBBKVoiN5LlSdcWxQcsrUcpMWK6sFUfsctv33bs4Ngy6a0NNq5Xpya2DzkEUPEP4F-SQQdwki-B0C9beheDJ6nffdvF0jaA3RvVoVI9G44_zsfW66qj540eFETjbAm9hcP435xv5AJuRF9vcGqfNq2-DXj5zQAEQz5a8ED99G4RI</recordid><startdate>20070413</startdate><enddate>20070413</enddate><creator>Ventura, Mario</creator><creator>Antonacci, Francesca</creator><creator>Cardone, Maria Francesca</creator><creator>Stanyon, Roscoe</creator><creator>D'Addabbo, Pietro</creator><creator>Cellamare, Angelo</creator><creator>Sprague, L. James</creator><creator>Eichler, Evan E</creator><creator>Archidiacono, Nicoletta</creator><creator>Rocchi, Mariano</creator><general>American Association for the Advancement of Science</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20070413</creationdate><title>Evolutionary Formation of New Centromeres in Macaque</title><author>Ventura, Mario ; Antonacci, Francesca ; Cardone, Maria Francesca ; Stanyon, Roscoe ; D'Addabbo, Pietro ; Cellamare, Angelo ; Sprague, L. James ; Eichler, Evan E ; Archidiacono, Nicoletta ; Rocchi, Mariano</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c509t-2b5f845e5bae7705e086ed91c6fb3ed33365b11d52766cb21d1f2b39543f26ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Centromere</topic><topic>Centromeres</topic><topic>Chromosomes</topic><topic>Chromosomes, Human, Pair 6</topic><topic>DNA</topic><topic>Evolution</topic><topic>Evolution, Molecular</topic><topic>Gene Duplication</topic><topic>Genes</topic><topic>Genomes</topic><topic>Genomics</topic><topic>Human chromosomes</topic><topic>Humans</topic><topic>Macaca</topic><topic>Macaca mulatta - genetics</topic><topic>Molecular Sequence Data</topic><topic>Seeding</topic><topic>Sequence Tagged Sites</topic><topic>Sequencing</topic><topic>Synteny</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ventura, Mario</creatorcontrib><creatorcontrib>Antonacci, Francesca</creatorcontrib><creatorcontrib>Cardone, Maria Francesca</creatorcontrib><creatorcontrib>Stanyon, Roscoe</creatorcontrib><creatorcontrib>D'Addabbo, Pietro</creatorcontrib><creatorcontrib>Cellamare, Angelo</creatorcontrib><creatorcontrib>Sprague, L. James</creatorcontrib><creatorcontrib>Eichler, Evan E</creatorcontrib><creatorcontrib>Archidiacono, Nicoletta</creatorcontrib><creatorcontrib>Rocchi, Mariano</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ventura, Mario</au><au>Antonacci, Francesca</au><au>Cardone, Maria Francesca</au><au>Stanyon, Roscoe</au><au>D'Addabbo, Pietro</au><au>Cellamare, Angelo</au><au>Sprague, L. James</au><au>Eichler, Evan E</au><au>Archidiacono, Nicoletta</au><au>Rocchi, Mariano</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evolutionary Formation of New Centromeres in Macaque</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>2007-04-13</date><risdate>2007</risdate><volume>316</volume><issue>5822</issue><spage>243</spage><epage>246</epage><pages>243-246</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><abstract>A systematic fluorescence in situ hybridization comparison of macaque and human synteny organization disclosed five additional macaque evolutionary new centromeres (ENCs) for a total of nine ENCs. To understand the dynamics of ENC formation and progression, we compared the ENC of macaque chromosome 4 with the human orthologous region, at 6q24.3, that conserves the ancestral genomic organization. A 250-kilobase segment was extensively duplicated around the macaque centromere. These duplications were strictly intrachromosomal. Our results suggest that novel centromeres may trigger only local duplication activity and that the absence of genes in the seeding region may have been important in ENC maintenance and progression.</abstract><cop>United States</cop><pub>American Association for the Advancement of Science</pub><pmid>17431171</pmid><doi>10.1126/science.1140615</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 2007-04, Vol.316 (5822), p.243-246 |
| issn | 0036-8075 1095-9203 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70382410 |
| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Animals Base Sequence Centromere Centromeres Chromosomes Chromosomes, Human, Pair 6 DNA Evolution Evolution, Molecular Gene Duplication Genes Genomes Genomics Human chromosomes Humans Macaca Macaca mulatta - genetics Molecular Sequence Data Seeding Sequence Tagged Sites Sequencing Synteny |
| title | Evolutionary Formation of New Centromeres in Macaque |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-01T03%3A10%3A44IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-jstor_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Evolutionary%20Formation%20of%20New%20Centromeres%20in%20Macaque&rft.jtitle=Science%20(American%20Association%20for%20the%20Advancement%20of%20Science)&rft.au=Ventura,%20Mario&rft.date=2007-04-13&rft.volume=316&rft.issue=5822&rft.spage=243&rft.epage=246&rft.pages=243-246&rft.issn=0036-8075&rft.eissn=1095-9203&rft_id=info:doi/10.1126/science.1140615&rft_dat=%3Cjstor_proqu%3E20036004%3C/jstor_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=20408454&rft_id=info:pmid/17431171&rft_jstor_id=20036004&rfr_iscdi=true |