Predictors of first-year survival in patients with advanced COPD treated using long-term oxygen therapy
Summary Little evidence-based guidance is available to aid clinicians in determining short-term prognoses in very severe COPD patients. Therefore, the present study was designed to provide a prospective assessment (1) of the mortality rates and (2) whether the baseline measurements may be determinan...
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| Veröffentlicht in: | Respiratory medicine 2008-04, Vol.102 (4), p.512-518 |
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| creator | Coleta, Karina Dela Silveira, Liciana V.A Lima, Daniela F Rampinelli, Eva A Godoy, Ilda Godoy, Irma |
| description | Summary Little evidence-based guidance is available to aid clinicians in determining short-term prognoses in very severe COPD patients. Therefore, the present study was designed to provide a prospective assessment (1) of the mortality rates and (2) whether the baseline measurements may be determinants of 1-year mortality in hypoxemic COPD patients receiving long-term oxygen therapy (LTOT). Seventy-eight clinically stable patients with advanced COPD treated using LTOT were enrolled in a prospective cohort study. Outcome variable: first-year mortality. Baseline measurements: categorical variables: age ( |
| doi_str_mv | 10.1016/j.rmed.2007.12.003 |
| format | Article |
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Therefore, the present study was designed to provide a prospective assessment (1) of the mortality rates and (2) whether the baseline measurements may be determinants of 1-year mortality in hypoxemic COPD patients receiving long-term oxygen therapy (LTOT). Seventy-eight clinically stable patients with advanced COPD treated using LTOT were enrolled in a prospective cohort study. Outcome variable: first-year mortality. Baseline measurements: categorical variables: age (<60 or ⩾60 years); gender; body mass index (<20 or ⩾20 kg/m2 ); fat-free mass (FFM) index (<16 [men] and <15 kg/m2 [women]; baseline dyspnea index (BDI) (⩽3 or >3); and corticosteroid use. Continuous variables: smoking history; lung function; FFM; fat mass; hemoglobin; hematocrit; arterial blood gases; forearm muscle strength; St. George's Respiratory Questionnaire (SGRQ); and comorbidity score. By the end of 1-year of follow-up, 12 patients (15.4%) had died. Kaplan–Meier curves showed that BDI⩽3 was the only variable associated with higher mortality. Cox proportional hazards analysis revealed that lower P aO2 and S pO2 , higher P aCO2 and SGRQ scores were associated with reduced survival. In the multivariate analysis, BDI remained predictive of mortality (hazard ratio [HR], 0.50; 95% confidence interval [CI], 0.31–0.81), as did P aO2 (HR, 0.49; 95% CI, 0.26–0.95). These data suggest that readily available parameters as dyspnea intensity and hypoxemia severity may be useful in predicting first-year survival rates in advanced COPD patients receiving LTOT.</description><identifier>ISSN: 0954-6111</identifier><identifier>EISSN: 1532-3064</identifier><identifier>DOI: 10.1016/j.rmed.2007.12.003</identifier><identifier>PMID: 18191558</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Aged ; Airway management ; Biological and medical sciences ; Body mass index ; Carbon dioxide ; Chronic obstructive pulmonary disease, asthma ; Chronic obstructive/mortality ; Confidence intervals ; Dyspnea ; Dyspnea - mortality ; Dyspnea - physiopathology ; Dyspnea - therapy ; Female ; Health Status Indicators ; Humans ; Lung - physiopathology ; Male ; Medical sciences ; Middle Aged ; Mortality ; Older people ; Oxygen ; Oxygen Inhalation Therapy ; Oxygen inhalation therapy/utilization ; Oxygen therapy ; Pneumology ; Prognosis ; Proportional Hazards Models ; Prospective Studies ; Pulmonary disease ; Pulmonary Disease, Chronic Obstructive - mortality ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary Disease, Chronic Obstructive - therapy ; Pulmonary/Respiratory ; Questionnaires ; Respiratory system : syndromes and miscellaneous diseases ; Studies ; Survival Rate</subject><ispartof>Respiratory medicine, 2008-04, Vol.102 (4), p.512-518</ispartof><rights>Elsevier Ltd</rights><rights>2007 Elsevier Ltd</rights><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c511t-1f4a607023182d3120b2ee8a9b26e0d93cfbe0f263a98179442e45d6f1a098f83</citedby><cites>FETCH-LOGICAL-c511t-1f4a607023182d3120b2ee8a9b26e0d93cfbe0f263a98179442e45d6f1a098f83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0954611107004866$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20217178$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18191558$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Coleta, Karina Dela</creatorcontrib><creatorcontrib>Silveira, Liciana V.A</creatorcontrib><creatorcontrib>Lima, Daniela F</creatorcontrib><creatorcontrib>Rampinelli, Eva A</creatorcontrib><creatorcontrib>Godoy, Ilda</creatorcontrib><creatorcontrib>Godoy, Irma</creatorcontrib><title>Predictors of first-year survival in patients with advanced COPD treated using long-term oxygen therapy</title><title>Respiratory medicine</title><addtitle>Respir Med</addtitle><description>Summary Little evidence-based guidance is available to aid clinicians in determining short-term prognoses in very severe COPD patients. Therefore, the present study was designed to provide a prospective assessment (1) of the mortality rates and (2) whether the baseline measurements may be determinants of 1-year mortality in hypoxemic COPD patients receiving long-term oxygen therapy (LTOT). Seventy-eight clinically stable patients with advanced COPD treated using LTOT were enrolled in a prospective cohort study. Outcome variable: first-year mortality. Baseline measurements: categorical variables: age (<60 or ⩾60 years); gender; body mass index (<20 or ⩾20 kg/m2 ); fat-free mass (FFM) index (<16 [men] and <15 kg/m2 [women]; baseline dyspnea index (BDI) (⩽3 or >3); and corticosteroid use. Continuous variables: smoking history; lung function; FFM; fat mass; hemoglobin; hematocrit; arterial blood gases; forearm muscle strength; St. George's Respiratory Questionnaire (SGRQ); and comorbidity score. By the end of 1-year of follow-up, 12 patients (15.4%) had died. Kaplan–Meier curves showed that BDI⩽3 was the only variable associated with higher mortality. Cox proportional hazards analysis revealed that lower P aO2 and S pO2 , higher P aCO2 and SGRQ scores were associated with reduced survival. In the multivariate analysis, BDI remained predictive of mortality (hazard ratio [HR], 0.50; 95% confidence interval [CI], 0.31–0.81), as did P aO2 (HR, 0.49; 95% CI, 0.26–0.95). These data suggest that readily available parameters as dyspnea intensity and hypoxemia severity may be useful in predicting first-year survival rates in advanced COPD patients receiving LTOT.</description><subject>Aged</subject><subject>Airway management</subject><subject>Biological and medical sciences</subject><subject>Body mass index</subject><subject>Carbon dioxide</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Chronic obstructive/mortality</subject><subject>Confidence intervals</subject><subject>Dyspnea</subject><subject>Dyspnea - mortality</subject><subject>Dyspnea - physiopathology</subject><subject>Dyspnea - therapy</subject><subject>Female</subject><subject>Health Status Indicators</subject><subject>Humans</subject><subject>Lung - physiopathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Older people</subject><subject>Oxygen</subject><subject>Oxygen Inhalation Therapy</subject><subject>Oxygen inhalation therapy/utilization</subject><subject>Oxygen therapy</subject><subject>Pneumology</subject><subject>Prognosis</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Pulmonary disease</subject><subject>Pulmonary Disease, Chronic Obstructive - mortality</subject><subject>Pulmonary Disease, Chronic Obstructive - physiopathology</subject><subject>Pulmonary Disease, Chronic Obstructive - therapy</subject><subject>Pulmonary/Respiratory</subject><subject>Questionnaires</subject><subject>Respiratory system : syndromes and miscellaneous diseases</subject><subject>Studies</subject><subject>Survival Rate</subject><issn>0954-6111</issn><issn>1532-3064</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kluLFDEQhYMo7rj6B3yQgOhbt1VJX0EEGa-wsAvqc8ikK7MZe7rHJD3a_940M6ywDz6FkO9Uqs4pxp4j5AhYvdnlfk9dLgDqHEUOIB-wFZZSZBKq4iFbQVsWWYWIF-xJCDsAaIsCHrMLbLDFsmxWbHvjqXMmjj7w0XLrfIjZTNrzMPmjO-qeu4EfdHQ0xMB_u3jLdXfUg6GOr69vPvDoScd0mYIbtrwfh20Wye_5-Gfe0sDjLXl9mJ-yR1b3gZ6dz0v249PH7-sv2dX156_r91eZKRFjhrbQFdQgJDaikyhgI4ga3W5ERdC10tgNgRWV1G2DdRpHUFF2lUUNbWMbeclen-oe_PhrohDV3gVDfa8HGqegapCNECUm8OU9cDdOfki9KQRZQlEjtokSJ8r4MQRPVh2822s_J0gtIaidWkJQSwgKhUohJNGLc-lps7zdSc6uJ-DVGdDB6N76ZKcLd5wAgTXWC_f2xFFy7OjIq2BSDsl658lE1Y3u_328uyc3vRtc-vEnzRT-zatCEqhvy7os25L8h6KpKvkXbD-5VA</recordid><startdate>20080401</startdate><enddate>20080401</enddate><creator>Coleta, Karina Dela</creator><creator>Silveira, Liciana V.A</creator><creator>Lima, Daniela F</creator><creator>Rampinelli, Eva A</creator><creator>Godoy, Ilda</creator><creator>Godoy, Irma</creator><general>Elsevier Ltd</general><general>Elsevier</general><general>Elsevier Limited</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>ASE</scope><scope>FPQ</scope><scope>H94</scope><scope>K6X</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20080401</creationdate><title>Predictors of first-year survival in patients with advanced COPD treated using long-term oxygen therapy</title><author>Coleta, Karina Dela ; Silveira, Liciana V.A ; Lima, Daniela F ; Rampinelli, Eva A ; Godoy, Ilda ; Godoy, Irma</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c511t-1f4a607023182d3120b2ee8a9b26e0d93cfbe0f263a98179442e45d6f1a098f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Aged</topic><topic>Airway management</topic><topic>Biological and medical sciences</topic><topic>Body mass index</topic><topic>Carbon dioxide</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Chronic obstructive/mortality</topic><topic>Confidence intervals</topic><topic>Dyspnea</topic><topic>Dyspnea - mortality</topic><topic>Dyspnea - physiopathology</topic><topic>Dyspnea - therapy</topic><topic>Female</topic><topic>Health Status Indicators</topic><topic>Humans</topic><topic>Lung - physiopathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Older people</topic><topic>Oxygen</topic><topic>Oxygen Inhalation Therapy</topic><topic>Oxygen inhalation therapy/utilization</topic><topic>Oxygen therapy</topic><topic>Pneumology</topic><topic>Prognosis</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Pulmonary disease</topic><topic>Pulmonary Disease, Chronic Obstructive - mortality</topic><topic>Pulmonary Disease, Chronic Obstructive - physiopathology</topic><topic>Pulmonary Disease, Chronic Obstructive - therapy</topic><topic>Pulmonary/Respiratory</topic><topic>Questionnaires</topic><topic>Respiratory system : syndromes and miscellaneous diseases</topic><topic>Studies</topic><topic>Survival Rate</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Coleta, Karina Dela</creatorcontrib><creatorcontrib>Silveira, Liciana V.A</creatorcontrib><creatorcontrib>Lima, Daniela F</creatorcontrib><creatorcontrib>Rampinelli, Eva A</creatorcontrib><creatorcontrib>Godoy, Ilda</creatorcontrib><creatorcontrib>Godoy, Irma</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>British Nursing Index</collection><collection>British Nursing Index (BNI) (1985 to Present)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>British Nursing Index</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Respiratory medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Coleta, Karina Dela</au><au>Silveira, Liciana V.A</au><au>Lima, Daniela F</au><au>Rampinelli, Eva A</au><au>Godoy, Ilda</au><au>Godoy, Irma</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Predictors of first-year survival in patients with advanced COPD treated using long-term oxygen therapy</atitle><jtitle>Respiratory medicine</jtitle><addtitle>Respir Med</addtitle><date>2008-04-01</date><risdate>2008</risdate><volume>102</volume><issue>4</issue><spage>512</spage><epage>518</epage><pages>512-518</pages><issn>0954-6111</issn><eissn>1532-3064</eissn><abstract>Summary Little evidence-based guidance is available to aid clinicians in determining short-term prognoses in very severe COPD patients. Therefore, the present study was designed to provide a prospective assessment (1) of the mortality rates and (2) whether the baseline measurements may be determinants of 1-year mortality in hypoxemic COPD patients receiving long-term oxygen therapy (LTOT). Seventy-eight clinically stable patients with advanced COPD treated using LTOT were enrolled in a prospective cohort study. Outcome variable: first-year mortality. Baseline measurements: categorical variables: age (<60 or ⩾60 years); gender; body mass index (<20 or ⩾20 kg/m2 ); fat-free mass (FFM) index (<16 [men] and <15 kg/m2 [women]; baseline dyspnea index (BDI) (⩽3 or >3); and corticosteroid use. Continuous variables: smoking history; lung function; FFM; fat mass; hemoglobin; hematocrit; arterial blood gases; forearm muscle strength; St. George's Respiratory Questionnaire (SGRQ); and comorbidity score. By the end of 1-year of follow-up, 12 patients (15.4%) had died. Kaplan–Meier curves showed that BDI⩽3 was the only variable associated with higher mortality. Cox proportional hazards analysis revealed that lower P aO2 and S pO2 , higher P aCO2 and SGRQ scores were associated with reduced survival. In the multivariate analysis, BDI remained predictive of mortality (hazard ratio [HR], 0.50; 95% confidence interval [CI], 0.31–0.81), as did P aO2 (HR, 0.49; 95% CI, 0.26–0.95). These data suggest that readily available parameters as dyspnea intensity and hypoxemia severity may be useful in predicting first-year survival rates in advanced COPD patients receiving LTOT.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>18191558</pmid><doi>10.1016/j.rmed.2007.12.003</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aged Airway management Biological and medical sciences Body mass index Carbon dioxide Chronic obstructive pulmonary disease, asthma Chronic obstructive/mortality Confidence intervals Dyspnea Dyspnea - mortality Dyspnea - physiopathology Dyspnea - therapy Female Health Status Indicators Humans Lung - physiopathology Male Medical sciences Middle Aged Mortality Older people Oxygen Oxygen Inhalation Therapy Oxygen inhalation therapy/utilization Oxygen therapy Pneumology Prognosis Proportional Hazards Models Prospective Studies Pulmonary disease Pulmonary Disease, Chronic Obstructive - mortality Pulmonary Disease, Chronic Obstructive - physiopathology Pulmonary Disease, Chronic Obstructive - therapy Pulmonary/Respiratory Questionnaires Respiratory system : syndromes and miscellaneous diseases Studies Survival Rate |
| title | Predictors of first-year survival in patients with advanced COPD treated using long-term oxygen therapy |
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