Long-term effects of early administered sildenafil and NO donor on the cardiovascular system of SHR

We evaluated the long-term effect of NO-donor, pentaerythrityl tetranitrate (Petn), and sildenafil citrate (sildenafil) on the cardiovascular system of the spontaneously hypertensive rat (SHR). Petn (100 mg/kg/day) and sildenafil (10 mg/kg/day) were administered to SHR individually or together from...

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Veröffentlicht in:Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 2007-03, Vol.58 (1), p.33-43
Hauptverfasser: Kristek, F, Koprdová, R, Cebová, M
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container_title Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
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creator Kristek, F
Koprdová, R
Cebová, M
description We evaluated the long-term effect of NO-donor, pentaerythrityl tetranitrate (Petn), and sildenafil citrate (sildenafil) on the cardiovascular system of the spontaneously hypertensive rat (SHR). Petn (100 mg/kg/day) and sildenafil (10 mg/kg/day) were administered to SHR individually or together from week 4 (pre-hypertensive period) to week 9 of age. Blood pressure (BP) was measured using a plethysmographic method. The animals were perfused with a glutaraldehyde fixative (120 mmHg). Carotid (AC) and coronary artery (RS) were processed according to electron microscopy procedure. Geometry of the arteries was measured on semi-thin sections using light microscopy. Administration of Petn and sildenafil to SHR individually or together did not prevent an increase of BP, but evoked a decrease of cardiac hypertrophy. Petn and sildenafil affected the geometry of RS and AC differently. In the RS, an increase of inner diameter (ID) without an increase of wall thickness (WT) resulted in increased WT/ID and circumferential stress. In the AC, changes in ID were accompanied by changes in WT and, thereby, WT/ID and circumferential stress remained unchanged. The arterial wall mass of both arteries was increased. The data suggest that administration of the NO donor, Petn, and/or sildenafil does not result in a beneficial effect on the myocardium or on the geometry of the carotid and coronary arteries.
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Petn (100 mg/kg/day) and sildenafil (10 mg/kg/day) were administered to SHR individually or together from week 4 (pre-hypertensive period) to week 9 of age. Blood pressure (BP) was measured using a plethysmographic method. The animals were perfused with a glutaraldehyde fixative (120 mmHg). Carotid (AC) and coronary artery (RS) were processed according to electron microscopy procedure. Geometry of the arteries was measured on semi-thin sections using light microscopy. Administration of Petn and sildenafil to SHR individually or together did not prevent an increase of BP, but evoked a decrease of cardiac hypertrophy. Petn and sildenafil affected the geometry of RS and AC differently. In the RS, an increase of inner diameter (ID) without an increase of wall thickness (WT) resulted in increased WT/ID and circumferential stress. In the AC, changes in ID were accompanied by changes in WT and, thereby, WT/ID and circumferential stress remained unchanged. The arterial wall mass of both arteries was increased. 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Petn (100 mg/kg/day) and sildenafil (10 mg/kg/day) were administered to SHR individually or together from week 4 (pre-hypertensive period) to week 9 of age. Blood pressure (BP) was measured using a plethysmographic method. The animals were perfused with a glutaraldehyde fixative (120 mmHg). Carotid (AC) and coronary artery (RS) were processed according to electron microscopy procedure. Geometry of the arteries was measured on semi-thin sections using light microscopy. Administration of Petn and sildenafil to SHR individually or together did not prevent an increase of BP, but evoked a decrease of cardiac hypertrophy. Petn and sildenafil affected the geometry of RS and AC differently. In the RS, an increase of inner diameter (ID) without an increase of wall thickness (WT) resulted in increased WT/ID and circumferential stress. In the AC, changes in ID were accompanied by changes in WT and, thereby, WT/ID and circumferential stress remained unchanged. The arterial wall mass of both arteries was increased. 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dosage</subject><subject>Nitric Oxide Donors - pharmacology</subject><subject>Pentaerythritol Tetranitrate - administration &amp; dosage</subject><subject>Phosphodiesterase Inhibitors - administration &amp; dosage</subject><subject>Phosphodiesterase Inhibitors - pharmacology</subject><subject>Piperazines - administration &amp; dosage</subject><subject>Piperazines - pharmacology</subject><subject>Purines - administration &amp; dosage</subject><subject>Purines - pharmacology</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Wistar</subject><subject>Sildenafil Citrate</subject><subject>Sulfones - administration &amp; dosage</subject><subject>Sulfones - pharmacology</subject><subject>Time Factors</subject><subject>Vasodilator Agents - administration &amp; dosage</subject><subject>Vasodilator Agents - pharmacology</subject><issn>0867-5910</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kEtLAzEcxHNQbK1-BcnJ20Jeu5s9SlErFAs-zkse_2gkm9RkV9hvb4v1NIeZ-cHMGVoS2bRV3VGyQJelfBHCqODNBVrQVgjCmFgis03xoxohDxicAzMWnBwGlcOMlR189OVggsXFBwtROR-wihY_77BNMWWcIh4_ARuVrU8_qpgpqIzLfKgNR9Tr5uUKnTsVClyfdIXeH-7f1ptqu3t8Wt9tqz0j3VjpRsoaNLOgpXTC1lYKzZuGdNQRYJxTJiworhrQXUtMTY4bDOWk0622hK_Q7R93n9P3BGXsB18MhKAipKn0LeGSUSoPwZtTcNID2H6f_aDy3P_fwn8BOKZdqw</recordid><startdate>200703</startdate><enddate>200703</enddate><creator>Kristek, F</creator><creator>Koprdová, R</creator><creator>Cebová, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200703</creationdate><title>Long-term effects of early administered sildenafil and NO donor on the cardiovascular system of SHR</title><author>Kristek, F ; 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dosage</topic><topic>Nitric Oxide Donors - pharmacology</topic><topic>Pentaerythritol Tetranitrate - administration &amp; dosage</topic><topic>Phosphodiesterase Inhibitors - administration &amp; dosage</topic><topic>Phosphodiesterase Inhibitors - pharmacology</topic><topic>Piperazines - administration &amp; dosage</topic><topic>Piperazines - pharmacology</topic><topic>Purines - administration &amp; dosage</topic><topic>Purines - pharmacology</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Wistar</topic><topic>Sildenafil Citrate</topic><topic>Sulfones - administration &amp; dosage</topic><topic>Sulfones - pharmacology</topic><topic>Time Factors</topic><topic>Vasodilator Agents - administration &amp; dosage</topic><topic>Vasodilator Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kristek, F</creatorcontrib><creatorcontrib>Koprdová, R</creatorcontrib><creatorcontrib>Cebová, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of physiology and pharmacology : an official journal of the Polish Physiological Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kristek, F</au><au>Koprdová, R</au><au>Cebová, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Long-term effects of early administered sildenafil and NO donor on the cardiovascular system of SHR</atitle><jtitle>Journal of physiology and pharmacology : an official journal of the Polish Physiological Society</jtitle><addtitle>J Physiol Pharmacol</addtitle><date>2007-03</date><risdate>2007</risdate><volume>58</volume><issue>1</issue><spage>33</spage><epage>43</epage><pages>33-43</pages><issn>0867-5910</issn><abstract>We evaluated the long-term effect of NO-donor, pentaerythrityl tetranitrate (Petn), and sildenafil citrate (sildenafil) on the cardiovascular system of the spontaneously hypertensive rat (SHR). Petn (100 mg/kg/day) and sildenafil (10 mg/kg/day) were administered to SHR individually or together from week 4 (pre-hypertensive period) to week 9 of age. Blood pressure (BP) was measured using a plethysmographic method. The animals were perfused with a glutaraldehyde fixative (120 mmHg). Carotid (AC) and coronary artery (RS) were processed according to electron microscopy procedure. Geometry of the arteries was measured on semi-thin sections using light microscopy. Administration of Petn and sildenafil to SHR individually or together did not prevent an increase of BP, but evoked a decrease of cardiac hypertrophy. Petn and sildenafil affected the geometry of RS and AC differently. In the RS, an increase of inner diameter (ID) without an increase of wall thickness (WT) resulted in increased WT/ID and circumferential stress. In the AC, changes in ID were accompanied by changes in WT and, thereby, WT/ID and circumferential stress remained unchanged. The arterial wall mass of both arteries was increased. The data suggest that administration of the NO donor, Petn, and/or sildenafil does not result in a beneficial effect on the myocardium or on the geometry of the carotid and coronary arteries.</abstract><cop>Poland</cop><pmid>17440224</pmid><tpages>11</tpages></addata></record>
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source MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry
subjects Animals
Antihypertensive Agents - administration & dosage
Antihypertensive Agents - pharmacology
Blood Pressure - drug effects
Cardiomegaly - etiology
Cardiomegaly - pathology
Cardiomegaly - physiopathology
Cardiomegaly - prevention & control
Cardiovascular System - drug effects
Carotid Arteries - drug effects
Carotid Arteries - pathology
Coronary Vessels - drug effects
Coronary Vessels - pathology
Disease Models, Animal
Disease Progression
Drug Administration Schedule
Drug Therapy, Combination
Hypertension - complications
Hypertension - drug therapy
Hypertension - pathology
Hypertension - physiopathology
Nitric Oxide Donors - administration & dosage
Nitric Oxide Donors - pharmacology
Pentaerythritol Tetranitrate - administration & dosage
Phosphodiesterase Inhibitors - administration & dosage
Phosphodiesterase Inhibitors - pharmacology
Piperazines - administration & dosage
Piperazines - pharmacology
Purines - administration & dosage
Purines - pharmacology
Rats
Rats, Inbred SHR
Rats, Wistar
Sildenafil Citrate
Sulfones - administration & dosage
Sulfones - pharmacology
Time Factors
Vasodilator Agents - administration & dosage
Vasodilator Agents - pharmacology
title Long-term effects of early administered sildenafil and NO donor on the cardiovascular system of SHR
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