Beginning of the End: Death Signaling in Early Involution
Mammary gland involution occurs in two distinct phases: an early, reversible phase, involving extensive apoptosis of the secretory alveolar epithelium without major changes in gland architecture, and a later, irreversible phase, involving remodelling of the gland to its pre-pregnancy state. Multiple...
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| Veröffentlicht in: | Journal of mammary gland biology and neoplasia 2007-03, Vol.12 (1), p.3-13 |
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| container_title | Journal of mammary gland biology and neoplasia |
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| creator | Baxter, Fiona O Neoh, Kevin Tevendale, Maxine C |
| description | Mammary gland involution occurs in two distinct phases: an early, reversible phase, involving extensive apoptosis of the secretory alveolar epithelium without major changes in gland architecture, and a later, irreversible phase, involving remodelling of the gland to its pre-pregnancy state. Multiple signalling pathways are known to be important during early involution, however the precise triggers remain elusive. This review summarizes the roles of a number of key pathways (NF-κB, PI(3)K, Stat3, and TGFβ) in the first phase of involution. |
| doi_str_mv | 10.1007/s10911-007-9033-9 |
| format | Article |
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| identifier | ISSN: 1083-3021 |
| ispartof | Journal of mammary gland biology and neoplasia, 2007-03, Vol.12 (1), p.3-13 |
| issn | 1083-3021 1573-7039 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Apoptosis - physiology Early involution Female Lactation - physiology Mammary Glands, Animal - metabolism Mammary Glands, Animal - physiology Mice NF-κB PIK Signal Transduction Stat3 TGFβ Weaning |
| title | Beginning of the End: Death Signaling in Early Involution |
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