The effect of repetitive transcranial magnetic stimulation (rTMS) add on serotonin reuptake inhibitors in patients with panic disorder: a randomized, double blind sham controlled study
Transcranial magnetic stimulation (rTMS) can modulate cortical activity. The goal of our study was to assess whether rTMS would facilitate effect of serotonin reuptake inhibitors in patients with panic disorder. Fifteen patients suffering from panic disorder resistant to serotonin reuptake inhibitor...
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| Veröffentlicht in: | Neuro-endocrinology letters 2007-02, Vol.28 (1), p.33-38 |
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| container_title | Neuro-endocrinology letters |
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| creator | Prasko, Ján Záleský, Richard Bares, Martin Horácek, Jirí Kopecek, Milan Novák, Tomás Pasková, Beata |
| description | Transcranial magnetic stimulation (rTMS) can modulate cortical activity. The goal of our study was to assess whether rTMS would facilitate effect of serotonin reuptake inhibitors in patients with panic disorder.
Fifteen patients suffering from panic disorder resistant to serotonin reuptake inhibitor (SRI) therapy were randomly assigned to either active or to sham rTMS. The aim of the study was to compare the 2 and 4 weeks efficacy of the 10 sessions 1 Hz rTMS with sham rTMS add on SRI therapy. We use 1 Hz, 30 minutes rTMS, 110% of motor threshold administered over the right dorso-lateral prefrontal cortex (DLPFC). The same time schedule was used for sham administration. Fifteen patients finished the study,. Psychopathology was assessed using the rating scales CGI, HAMA, PDSS and BAI before the treatment, immediately after the experimental treatment and 2 weeks after the experimental treatment by an independent reviewer.
Both groups improved during the study period but the treatment effect did not differ between groups in any of the instruments.
Low frequency rTMS administered over the right dorso-lateral prefrontal cortex after 10 sessions did not differ from sham rTMS add on serotonin reuptake inhibitors in patients with panic disorder. |
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Fifteen patients suffering from panic disorder resistant to serotonin reuptake inhibitor (SRI) therapy were randomly assigned to either active or to sham rTMS. The aim of the study was to compare the 2 and 4 weeks efficacy of the 10 sessions 1 Hz rTMS with sham rTMS add on SRI therapy. We use 1 Hz, 30 minutes rTMS, 110% of motor threshold administered over the right dorso-lateral prefrontal cortex (DLPFC). The same time schedule was used for sham administration. Fifteen patients finished the study,. Psychopathology was assessed using the rating scales CGI, HAMA, PDSS and BAI before the treatment, immediately after the experimental treatment and 2 weeks after the experimental treatment by an independent reviewer.
Both groups improved during the study period but the treatment effect did not differ between groups in any of the instruments.
Low frequency rTMS administered over the right dorso-lateral prefrontal cortex after 10 sessions did not differ from sham rTMS add on serotonin reuptake inhibitors in patients with panic disorder.</description><identifier>ISSN: 0172-780X</identifier><identifier>PMID: 17277734</identifier><language>eng</language><publisher>Sweden</publisher><subject>Adult ; Antidepressive Agents - therapeutic use ; Anxiety - physiopathology ; Combined Modality Therapy ; Double-Blind Method ; Female ; Humans ; Male ; Middle Aged ; Panic Disorder - physiopathology ; Panic Disorder - therapy ; Prefrontal Cortex - physiopathology ; Serotonin Uptake Inhibitors - therapeutic use ; Severity of Illness Index ; Transcranial Magnetic Stimulation - methods</subject><ispartof>Neuro-endocrinology letters, 2007-02, Vol.28 (1), p.33-38</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17277734$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Prasko, Ján</creatorcontrib><creatorcontrib>Záleský, Richard</creatorcontrib><creatorcontrib>Bares, Martin</creatorcontrib><creatorcontrib>Horácek, Jirí</creatorcontrib><creatorcontrib>Kopecek, Milan</creatorcontrib><creatorcontrib>Novák, Tomás</creatorcontrib><creatorcontrib>Pasková, Beata</creatorcontrib><title>The effect of repetitive transcranial magnetic stimulation (rTMS) add on serotonin reuptake inhibitors in patients with panic disorder: a randomized, double blind sham controlled study</title><title>Neuro-endocrinology letters</title><addtitle>Neuro Endocrinol Lett</addtitle><description>Transcranial magnetic stimulation (rTMS) can modulate cortical activity. The goal of our study was to assess whether rTMS would facilitate effect of serotonin reuptake inhibitors in patients with panic disorder.
Fifteen patients suffering from panic disorder resistant to serotonin reuptake inhibitor (SRI) therapy were randomly assigned to either active or to sham rTMS. The aim of the study was to compare the 2 and 4 weeks efficacy of the 10 sessions 1 Hz rTMS with sham rTMS add on SRI therapy. We use 1 Hz, 30 minutes rTMS, 110% of motor threshold administered over the right dorso-lateral prefrontal cortex (DLPFC). The same time schedule was used for sham administration. Fifteen patients finished the study,. Psychopathology was assessed using the rating scales CGI, HAMA, PDSS and BAI before the treatment, immediately after the experimental treatment and 2 weeks after the experimental treatment by an independent reviewer.
Both groups improved during the study period but the treatment effect did not differ between groups in any of the instruments.
Low frequency rTMS administered over the right dorso-lateral prefrontal cortex after 10 sessions did not differ from sham rTMS add on serotonin reuptake inhibitors in patients with panic disorder.</description><subject>Adult</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Anxiety - physiopathology</subject><subject>Combined Modality Therapy</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Panic Disorder - physiopathology</subject><subject>Panic Disorder - therapy</subject><subject>Prefrontal Cortex - physiopathology</subject><subject>Serotonin Uptake Inhibitors - therapeutic use</subject><subject>Severity of Illness Index</subject><subject>Transcranial Magnetic Stimulation - methods</subject><issn>0172-780X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1UE1LxDAQ7UFx19W_IHMSBQtN22xab7L4BSseXMFbSZqpjaZJTVJl_WX-PAOuMMzMm3nzBt5eMs8Iy1NWZS-z5ND7tyzLa5oXB8kszhljRTlPfjY9AnYdtgFsBw5HDCqoT4TguPFtTIprGPiriYsWfFDDpHlQ1sCZ2zw8nQOXEiLy6GywRpkoMo2BvyMo0yuhgnU-tjDGKzTBw5cKfUQmyknlrZPoLoFDfCXtoL5RXoC0k9AIQisjwfd8gNaa4KzWGHGY5PYo2e-49ni8q4vk-eZ6s7pL14-396urdTqSvAxpTfJK1llRcdnmNAZlJdZMLiWNdghCeU4EKwQp5RIJpbUgLKOVrGpOWs5psUhO_3RHZz8m9KEZlG9Ra27QTr5hUTtjtIrEkx1xEgPKZnRq4G7b_Htd_AIaA34m</recordid><startdate>200702</startdate><enddate>200702</enddate><creator>Prasko, Ján</creator><creator>Záleský, Richard</creator><creator>Bares, Martin</creator><creator>Horácek, Jirí</creator><creator>Kopecek, Milan</creator><creator>Novák, Tomás</creator><creator>Pasková, Beata</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>200702</creationdate><title>The effect of repetitive transcranial magnetic stimulation (rTMS) add on serotonin reuptake inhibitors in patients with panic disorder: a randomized, double blind sham controlled study</title><author>Prasko, Ján ; Záleský, Richard ; Bares, Martin ; Horácek, Jirí ; Kopecek, Milan ; Novák, Tomás ; Pasková, Beata</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p124t-9128d9038adc25c25574e97d6d5002b15a21b73b14d6e1559b17058d89a1caa53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adult</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Anxiety - physiopathology</topic><topic>Combined Modality Therapy</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Panic Disorder - physiopathology</topic><topic>Panic Disorder - therapy</topic><topic>Prefrontal Cortex - physiopathology</topic><topic>Serotonin Uptake Inhibitors - therapeutic use</topic><topic>Severity of Illness Index</topic><topic>Transcranial Magnetic Stimulation - methods</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Prasko, Ján</creatorcontrib><creatorcontrib>Záleský, Richard</creatorcontrib><creatorcontrib>Bares, Martin</creatorcontrib><creatorcontrib>Horácek, Jirí</creatorcontrib><creatorcontrib>Kopecek, Milan</creatorcontrib><creatorcontrib>Novák, Tomás</creatorcontrib><creatorcontrib>Pasková, Beata</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Neuro-endocrinology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Prasko, Ján</au><au>Záleský, Richard</au><au>Bares, Martin</au><au>Horácek, Jirí</au><au>Kopecek, Milan</au><au>Novák, Tomás</au><au>Pasková, Beata</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of repetitive transcranial magnetic stimulation (rTMS) add on serotonin reuptake inhibitors in patients with panic disorder: a randomized, double blind sham controlled study</atitle><jtitle>Neuro-endocrinology letters</jtitle><addtitle>Neuro Endocrinol Lett</addtitle><date>2007-02</date><risdate>2007</risdate><volume>28</volume><issue>1</issue><spage>33</spage><epage>38</epage><pages>33-38</pages><issn>0172-780X</issn><abstract>Transcranial magnetic stimulation (rTMS) can modulate cortical activity. The goal of our study was to assess whether rTMS would facilitate effect of serotonin reuptake inhibitors in patients with panic disorder.
Fifteen patients suffering from panic disorder resistant to serotonin reuptake inhibitor (SRI) therapy were randomly assigned to either active or to sham rTMS. The aim of the study was to compare the 2 and 4 weeks efficacy of the 10 sessions 1 Hz rTMS with sham rTMS add on SRI therapy. We use 1 Hz, 30 minutes rTMS, 110% of motor threshold administered over the right dorso-lateral prefrontal cortex (DLPFC). The same time schedule was used for sham administration. Fifteen patients finished the study,. Psychopathology was assessed using the rating scales CGI, HAMA, PDSS and BAI before the treatment, immediately after the experimental treatment and 2 weeks after the experimental treatment by an independent reviewer.
Both groups improved during the study period but the treatment effect did not differ between groups in any of the instruments.
Low frequency rTMS administered over the right dorso-lateral prefrontal cortex after 10 sessions did not differ from sham rTMS add on serotonin reuptake inhibitors in patients with panic disorder.</abstract><cop>Sweden</cop><pmid>17277734</pmid><tpages>6</tpages></addata></record> |
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| ispartof | Neuro-endocrinology letters, 2007-02, Vol.28 (1), p.33-38 |
| issn | 0172-780X |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Antidepressive Agents - therapeutic use Anxiety - physiopathology Combined Modality Therapy Double-Blind Method Female Humans Male Middle Aged Panic Disorder - physiopathology Panic Disorder - therapy Prefrontal Cortex - physiopathology Serotonin Uptake Inhibitors - therapeutic use Severity of Illness Index Transcranial Magnetic Stimulation - methods |
| title | The effect of repetitive transcranial magnetic stimulation (rTMS) add on serotonin reuptake inhibitors in patients with panic disorder: a randomized, double blind sham controlled study |
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