High prevalence of atopy, but not of asthma, among children in an industrialized area in North Italy: The role of familial and environmental factors - a population-based study
The prevalence of atopy and asthma, and their association with familial and environmental factors were investigated among 13‐ to 14‐yr‐old children living in Brescia, an industrialized town in North Italy. All the 1450 children attending primary school in the town were invited to participate, and 96...
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| creator | Duse, Marzia Donato, Francesco Porteri, Vera Pirali, Francesco Spinoni, Vania Tosoni, Cinzia Vettore, Manuela Lombardi, Carlo |
| description | The prevalence of atopy and asthma, and their association with familial and environmental factors were investigated among 13‐ to 14‐yr‐old children living in Brescia, an industrialized town in North Italy. All the 1450 children attending primary school in the town were invited to participate, and 967 of them (66.7%, 493 males) provided a valid questionnaire filled in by their parents at home. We used a modified version of the questionnaire adopted in the Italian Study of Respiratory Disorders in Childhood and Environment, which is an extended version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Six hundred and twenty‐eight subjects underwent skin prick test (SPT), and 308 of them (49%) were positive for at least one of the 12 allergen extracts commonly employed. Ninety‐nine children (10.2%) had a physician's diagnosis of asthma – 12.4% of the males and 8.0% of the females (p = 0.03). The prevalence of wheezing in the past 12 months was 6.2%. Atopy was found in 76.8% of the subjects with, and in 45.6% of those without physician's diagnosis of asthma (p |
| doi_str_mv | 10.1111/j.1399-3038.2006.00523.x |
| format | Article |
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All the 1450 children attending primary school in the town were invited to participate, and 967 of them (66.7%, 493 males) provided a valid questionnaire filled in by their parents at home. We used a modified version of the questionnaire adopted in the Italian Study of Respiratory Disorders in Childhood and Environment, which is an extended version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Six hundred and twenty‐eight subjects underwent skin prick test (SPT), and 308 of them (49%) were positive for at least one of the 12 allergen extracts commonly employed. Ninety‐nine children (10.2%) had a physician's diagnosis of asthma – 12.4% of the males and 8.0% of the females (p = 0.03). The prevalence of wheezing in the past 12 months was 6.2%. Atopy was found in 76.8% of the subjects with, and in 45.6% of those without physician's diagnosis of asthma (p < 0.001). Analysis by multiple logistic regression showed an inverse association between physician‐diagnosed asthma and female sex (odds ratio, OR = 0.5); presence of relatives in the bedroom in initial years of life (OR = 0.6); attending day care (OR = 0.4) and infant school (OR = 0.4); a positive association with parental history of wheezing (OR = 2.5) and asthma (OR = 3.8); and the child's history of asthmatic bronchitis (OR = 31.9) and atopic eczema (OR = 3.8) in the first 2 yr of life. The strength of the associations did not change when restricting the analysis to atopic asthma. In conclusion, atopy and clinical asthma among 13‐ to 14‐yr‐old adolescents are significantly associated with some familial and environmental factors, providing further support for the hygiene hypothesis. Prevalence of atopy, but not of asthma, is high in this industrialized area. The strong association found between atopy and clinical asthma suggests that atopy may play a role in causing asthma in genetically predisposed children only.</description><identifier>ISSN: 0905-6157</identifier><identifier>EISSN: 1399-3038</identifier><identifier>DOI: 10.1111/j.1399-3038.2006.00523.x</identifier><identifier>PMID: 17346295</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adolescent ; asthma ; Asthma - epidemiology ; Asthma - etiology ; Asthma - prevention & control ; atopy ; Biological and medical sciences ; childhood ; Chronic obstructive pulmonary disease, asthma ; Cross-Sectional Studies ; cross-sectional study ; Environment ; Female ; Genetic Predisposition to Disease ; Humans ; Hypersensitivity, Immediate - epidemiology ; Immunopathology ; Italy ; Male ; Medical sciences ; Pneumology ; Prevalence ; Risk Factors ; Sex Factors ; skin prick test ; Skin Tests ; Surveys and Questionnaires ; Urban Population ; wheezing</subject><ispartof>Pediatric allergy and immunology, 2007-05, Vol.18 (3), p.201-208</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4653-e90597661d5e7e39e32684dadc52c99404c63b0a861e4ce797d4424a62a3c2703</citedby><cites>FETCH-LOGICAL-c4653-e90597661d5e7e39e32684dadc52c99404c63b0a861e4ce797d4424a62a3c2703</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1399-3038.2006.00523.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1399-3038.2006.00523.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18671083$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17346295$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Duse, Marzia</creatorcontrib><creatorcontrib>Donato, Francesco</creatorcontrib><creatorcontrib>Porteri, Vera</creatorcontrib><creatorcontrib>Pirali, Francesco</creatorcontrib><creatorcontrib>Spinoni, Vania</creatorcontrib><creatorcontrib>Tosoni, Cinzia</creatorcontrib><creatorcontrib>Vettore, Manuela</creatorcontrib><creatorcontrib>Lombardi, Carlo</creatorcontrib><title>High prevalence of atopy, but not of asthma, among children in an industrialized area in North Italy: The role of familial and environmental factors - a population-based study</title><title>Pediatric allergy and immunology</title><addtitle>Pediatr Allergy Immunol</addtitle><description>The prevalence of atopy and asthma, and their association with familial and environmental factors were investigated among 13‐ to 14‐yr‐old children living in Brescia, an industrialized town in North Italy. All the 1450 children attending primary school in the town were invited to participate, and 967 of them (66.7%, 493 males) provided a valid questionnaire filled in by their parents at home. We used a modified version of the questionnaire adopted in the Italian Study of Respiratory Disorders in Childhood and Environment, which is an extended version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Six hundred and twenty‐eight subjects underwent skin prick test (SPT), and 308 of them (49%) were positive for at least one of the 12 allergen extracts commonly employed. Ninety‐nine children (10.2%) had a physician's diagnosis of asthma – 12.4% of the males and 8.0% of the females (p = 0.03). The prevalence of wheezing in the past 12 months was 6.2%. Atopy was found in 76.8% of the subjects with, and in 45.6% of those without physician's diagnosis of asthma (p < 0.001). Analysis by multiple logistic regression showed an inverse association between physician‐diagnosed asthma and female sex (odds ratio, OR = 0.5); presence of relatives in the bedroom in initial years of life (OR = 0.6); attending day care (OR = 0.4) and infant school (OR = 0.4); a positive association with parental history of wheezing (OR = 2.5) and asthma (OR = 3.8); and the child's history of asthmatic bronchitis (OR = 31.9) and atopic eczema (OR = 3.8) in the first 2 yr of life. The strength of the associations did not change when restricting the analysis to atopic asthma. In conclusion, atopy and clinical asthma among 13‐ to 14‐yr‐old adolescents are significantly associated with some familial and environmental factors, providing further support for the hygiene hypothesis. Prevalence of atopy, but not of asthma, is high in this industrialized area. The strong association found between atopy and clinical asthma suggests that atopy may play a role in causing asthma in genetically predisposed children only.</description><subject>Adolescent</subject><subject>asthma</subject><subject>Asthma - epidemiology</subject><subject>Asthma - etiology</subject><subject>Asthma - prevention & control</subject><subject>atopy</subject><subject>Biological and medical sciences</subject><subject>childhood</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Cross-Sectional Studies</subject><subject>cross-sectional study</subject><subject>Environment</subject><subject>Female</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Hypersensitivity, Immediate - epidemiology</subject><subject>Immunopathology</subject><subject>Italy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pneumology</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>skin prick test</subject><subject>Skin Tests</subject><subject>Surveys and Questionnaires</subject><subject>Urban Population</subject><subject>wheezing</subject><issn>0905-6157</issn><issn>1399-3038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkdFu0zAUhiMEYmXwCsg3cLUUJ07sBHEzVbBVmsouhoa4sU6d09XFiTPbGS0vxSvitNV2Cb7wOfL5_t-2_iQhGZ1mcX3YTDNW1ymjrJrmlPIppWXOpttnyeRx8DyZ0JqWKc9KcZK88n5DaSYYz14mJ7EWPK_LSfLnUt-tSe_wAQx2ColdEQi2352R5RBIZ8P-xId1C2cEWtvdEbXWpnHYEd0RGPdm8MFpMPo3NgQcwjhZWBfWZB7A7D6SmzUSZ83efgWtNpGO2oZg96Cd7VrsIhhHKljnSUqA9LYfDARtu3QJPhr7MDS718mLFRiPb471NPn25fPN7DK9-noxn51fpargJUsx_rwWnGdNiQJZjSznVdFAo8pc1XVBC8XZkkLFMywUilo0RZEXwHNgKheUnSbvD769s_cD-iBb7RUaAx3awcuIiLrk_J9gTgtBaTE6VgdQOeu9w5XsnW7B7WRG5Ziq3MgxPDmGJ8dU5T5VuY3St8c7hmWLzZPwGGME3h0B8ArMykGntH_iKi4yWrHIfTpwv7TB3X8_QF6fz2MT5elBrn3A7aMc3E_JBROlvF1cyNmPWXWd3y7kd_YX21zNrA</recordid><startdate>200705</startdate><enddate>200705</enddate><creator>Duse, Marzia</creator><creator>Donato, Francesco</creator><creator>Porteri, Vera</creator><creator>Pirali, Francesco</creator><creator>Spinoni, Vania</creator><creator>Tosoni, Cinzia</creator><creator>Vettore, Manuela</creator><creator>Lombardi, Carlo</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>200705</creationdate><title>High prevalence of atopy, but not of asthma, among children in an industrialized area in North Italy: The role of familial and environmental factors - a population-based study</title><author>Duse, Marzia ; 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All the 1450 children attending primary school in the town were invited to participate, and 967 of them (66.7%, 493 males) provided a valid questionnaire filled in by their parents at home. We used a modified version of the questionnaire adopted in the Italian Study of Respiratory Disorders in Childhood and Environment, which is an extended version of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire. Six hundred and twenty‐eight subjects underwent skin prick test (SPT), and 308 of them (49%) were positive for at least one of the 12 allergen extracts commonly employed. Ninety‐nine children (10.2%) had a physician's diagnosis of asthma – 12.4% of the males and 8.0% of the females (p = 0.03). The prevalence of wheezing in the past 12 months was 6.2%. Atopy was found in 76.8% of the subjects with, and in 45.6% of those without physician's diagnosis of asthma (p < 0.001). Analysis by multiple logistic regression showed an inverse association between physician‐diagnosed asthma and female sex (odds ratio, OR = 0.5); presence of relatives in the bedroom in initial years of life (OR = 0.6); attending day care (OR = 0.4) and infant school (OR = 0.4); a positive association with parental history of wheezing (OR = 2.5) and asthma (OR = 3.8); and the child's history of asthmatic bronchitis (OR = 31.9) and atopic eczema (OR = 3.8) in the first 2 yr of life. The strength of the associations did not change when restricting the analysis to atopic asthma. In conclusion, atopy and clinical asthma among 13‐ to 14‐yr‐old adolescents are significantly associated with some familial and environmental factors, providing further support for the hygiene hypothesis. Prevalence of atopy, but not of asthma, is high in this industrialized area. The strong association found between atopy and clinical asthma suggests that atopy may play a role in causing asthma in genetically predisposed children only.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>17346295</pmid><doi>10.1111/j.1399-3038.2006.00523.x</doi><tpages>8</tpages></addata></record> |
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| subjects | Adolescent asthma Asthma - epidemiology Asthma - etiology Asthma - prevention & control atopy Biological and medical sciences childhood Chronic obstructive pulmonary disease, asthma Cross-Sectional Studies cross-sectional study Environment Female Genetic Predisposition to Disease Humans Hypersensitivity, Immediate - epidemiology Immunopathology Italy Male Medical sciences Pneumology Prevalence Risk Factors Sex Factors skin prick test Skin Tests Surveys and Questionnaires Urban Population wheezing |
| title | High prevalence of atopy, but not of asthma, among children in an industrialized area in North Italy: The role of familial and environmental factors - a population-based study |
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