Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma
Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma The study was designed as a 6 months randomized, observer-masked study comprising 120 patients with primary open-angle glaucoma in Feiz Hospital, Isfahan, Iran, from 2006 to 2007....
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| Veröffentlicht in: | Saudi medical journal 2008-03, Vol.29 (3), p.384-387 |
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| creator | RISMANCHIAN, Akram ESLAMI, Fateme MOEINI, Heidarali ATTARZADE, Hosein NADERIBENI, Afsane |
| description | Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma
The study was designed as a 6 months randomized, observer-masked study comprising 120 patients with primary open-angle glaucoma in Feiz Hospital, Isfahan, Iran, from 2006 to 2007. The patients were randomized (latanoprost, n = 60; dorzolamide/timolol, n = 60) to treatment with either latanoprost, 0.005% once daily, or the combination of timolol 0.5% twice daily, and dorzolamide 2% 3 times daily. The mean intraocular pressure (IOP) after one, 3, and 6 months of treatment was compared with baseline in the 2 groups.
A total of 120 patients were randomized to 2 equal treatment groups. The mean baseline IOP values were similar between the 2 groups. The mean (standard error of mean [SE]) IOP reductions at months one was 7.2 (0.4), at month 3 was 7.3 (0.4), and at month 6 was 7.1 (0.3) mm Hg for the latanoprost group and 7.5 (0.3), 7.8 (0.3), and 7.4 (0.3) mm Hg for the dorzolamide/timolol group. The 2 therapies were similarly effective.
The latanoprost and dorzolamide/timolol combination were equally effective at lowering IOP compared to untreated baseline. |
| format | Article |
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The study was designed as a 6 months randomized, observer-masked study comprising 120 patients with primary open-angle glaucoma in Feiz Hospital, Isfahan, Iran, from 2006 to 2007. The patients were randomized (latanoprost, n = 60; dorzolamide/timolol, n = 60) to treatment with either latanoprost, 0.005% once daily, or the combination of timolol 0.5% twice daily, and dorzolamide 2% 3 times daily. The mean intraocular pressure (IOP) after one, 3, and 6 months of treatment was compared with baseline in the 2 groups.
A total of 120 patients were randomized to 2 equal treatment groups. The mean baseline IOP values were similar between the 2 groups. The mean (standard error of mean [SE]) IOP reductions at months one was 7.2 (0.4), at month 3 was 7.3 (0.4), and at month 6 was 7.1 (0.3) mm Hg for the latanoprost group and 7.5 (0.3), 7.8 (0.3), and 7.4 (0.3) mm Hg for the dorzolamide/timolol group. The 2 therapies were similarly effective.
The latanoprost and dorzolamide/timolol combination were equally effective at lowering IOP compared to untreated baseline.</description><identifier>ISSN: 0379-5284</identifier><identifier>PMID: 18327364</identifier><identifier>CODEN: SAMJDI</identifier><language>eng</language><publisher>Riyadh: Saudi Medical Journal</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Antihypertensive Agents - therapeutic use ; Biological and medical sciences ; Drug Therapy, Combination ; Female ; General aspects ; Glaucoma and intraocular pressure ; Glaucoma, Open-Angle - drug therapy ; Humans ; Male ; Medical sciences ; Middle Aged ; Ophthalmology ; Prostaglandins F, Synthetic - therapeutic use ; Sulfonamides - therapeutic use ; Thiophenes - therapeutic use ; Timolol - therapeutic use</subject><ispartof>Saudi medical journal, 2008-03, Vol.29 (3), p.384-387</ispartof><rights>2008 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20242213$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18327364$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RISMANCHIAN, Akram</creatorcontrib><creatorcontrib>ESLAMI, Fateme</creatorcontrib><creatorcontrib>MOEINI, Heidarali</creatorcontrib><creatorcontrib>ATTARZADE, Hosein</creatorcontrib><creatorcontrib>NADERIBENI, Afsane</creatorcontrib><title>Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma</title><title>Saudi medical journal</title><addtitle>Saudi Med J</addtitle><description>Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma
The study was designed as a 6 months randomized, observer-masked study comprising 120 patients with primary open-angle glaucoma in Feiz Hospital, Isfahan, Iran, from 2006 to 2007. The patients were randomized (latanoprost, n = 60; dorzolamide/timolol, n = 60) to treatment with either latanoprost, 0.005% once daily, or the combination of timolol 0.5% twice daily, and dorzolamide 2% 3 times daily. The mean intraocular pressure (IOP) after one, 3, and 6 months of treatment was compared with baseline in the 2 groups.
A total of 120 patients were randomized to 2 equal treatment groups. The mean baseline IOP values were similar between the 2 groups. The mean (standard error of mean [SE]) IOP reductions at months one was 7.2 (0.4), at month 3 was 7.3 (0.4), and at month 6 was 7.1 (0.3) mm Hg for the latanoprost group and 7.5 (0.3), 7.8 (0.3), and 7.4 (0.3) mm Hg for the dorzolamide/timolol group. The 2 therapies were similarly effective.
The latanoprost and dorzolamide/timolol combination were equally effective at lowering IOP compared to untreated baseline.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Drug Therapy, Combination</subject><subject>Female</subject><subject>General aspects</subject><subject>Glaucoma and intraocular pressure</subject><subject>Glaucoma, Open-Angle - drug therapy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Ophthalmology</subject><subject>Prostaglandins F, Synthetic - therapeutic use</subject><subject>Sulfonamides - therapeutic use</subject><subject>Thiophenes - therapeutic use</subject><subject>Timolol - therapeutic use</subject><issn>0379-5284</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1OwzAQhH0A0VJ4BeQL3CIc23GcI6rKj1SJC5yjjWO3Ro4dYoeqPD2pCJxW2v1mtDNnaElYWWUFlXyBLmP8IIQJQcQFWuSS0ZIJvkSHjTFWgTriYHDaa-wggQ_9EGLCX3qIY8TJdsEFd9-G4Ts46GyrsQpdYz0kG_xJNkB_xNbjftponyI-2LTH_WA7GCbrXnsMfuc03jkYJy1coXMDLurrea7Q--Pmbf2cbV-fXtYP26ynrEqZMaKVLbAqb3JohNAFqUhjFGdcNaoUpiSyLBhnJZc6z6VW0uTKTKdC0VYytkJ3v75Tos9Rx1R3NirtHHgdxliXp444oxN4M4Nj0-m2nn-v_6qagNsZgKjAmQG8svGfo4RySnPGfgBp2nR7</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>RISMANCHIAN, Akram</creator><creator>ESLAMI, Fateme</creator><creator>MOEINI, Heidarali</creator><creator>ATTARZADE, Hosein</creator><creator>NADERIBENI, Afsane</creator><general>Saudi Medical Journal</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20080301</creationdate><title>Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma</title><author>RISMANCHIAN, Akram ; ESLAMI, Fateme ; MOEINI, Heidarali ; ATTARZADE, Hosein ; NADERIBENI, Afsane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-ff6d8da391b1ab66e5090bfc434cbc76f70875343748e118ec8f1cfbc75c2d833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Drug Therapy, Combination</topic><topic>Female</topic><topic>General aspects</topic><topic>Glaucoma and intraocular pressure</topic><topic>Glaucoma, Open-Angle - drug therapy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Ophthalmology</topic><topic>Prostaglandins F, Synthetic - therapeutic use</topic><topic>Sulfonamides - therapeutic use</topic><topic>Thiophenes - therapeutic use</topic><topic>Timolol - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RISMANCHIAN, Akram</creatorcontrib><creatorcontrib>ESLAMI, Fateme</creatorcontrib><creatorcontrib>MOEINI, Heidarali</creatorcontrib><creatorcontrib>ATTARZADE, Hosein</creatorcontrib><creatorcontrib>NADERIBENI, Afsane</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Saudi medical journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RISMANCHIAN, Akram</au><au>ESLAMI, Fateme</au><au>MOEINI, Heidarali</au><au>ATTARZADE, Hosein</au><au>NADERIBENI, Afsane</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma</atitle><jtitle>Saudi medical journal</jtitle><addtitle>Saudi Med J</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>29</volume><issue>3</issue><spage>384</spage><epage>387</epage><pages>384-387</pages><issn>0379-5284</issn><coden>SAMJDI</coden><abstract>Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma
The study was designed as a 6 months randomized, observer-masked study comprising 120 patients with primary open-angle glaucoma in Feiz Hospital, Isfahan, Iran, from 2006 to 2007. The patients were randomized (latanoprost, n = 60; dorzolamide/timolol, n = 60) to treatment with either latanoprost, 0.005% once daily, or the combination of timolol 0.5% twice daily, and dorzolamide 2% 3 times daily. The mean intraocular pressure (IOP) after one, 3, and 6 months of treatment was compared with baseline in the 2 groups.
A total of 120 patients were randomized to 2 equal treatment groups. The mean baseline IOP values were similar between the 2 groups. The mean (standard error of mean [SE]) IOP reductions at months one was 7.2 (0.4), at month 3 was 7.3 (0.4), and at month 6 was 7.1 (0.3) mm Hg for the latanoprost group and 7.5 (0.3), 7.8 (0.3), and 7.4 (0.3) mm Hg for the dorzolamide/timolol group. The 2 therapies were similarly effective.
The latanoprost and dorzolamide/timolol combination were equally effective at lowering IOP compared to untreated baseline.</abstract><cop>Riyadh</cop><pub>Saudi Medical Journal</pub><pmid>18327364</pmid><tpages>4</tpages></addata></record> |
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| ispartof | Saudi medical journal, 2008-03, Vol.29 (3), p.384-387 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Aged, 80 and over Antihypertensive Agents - therapeutic use Biological and medical sciences Drug Therapy, Combination Female General aspects Glaucoma and intraocular pressure Glaucoma, Open-Angle - drug therapy Humans Male Medical sciences Middle Aged Ophthalmology Prostaglandins F, Synthetic - therapeutic use Sulfonamides - therapeutic use Thiophenes - therapeutic use Timolol - therapeutic use |
| title | Efficacy of the latanoprost versus timolol/dorzolamide combination therapy in patients with primary open angle glaucoma |
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