The involvement of the sLe-a selectin ligand in the extravasation of human colorectal carcinoma cells

Abstract The extravasation of tumor cells is a pivotal stage in the formation of hematogenous metastasis. An interaction of selectins expressed on endothelial cells and selectin ligands expressed by tumor cells has been implicated to play a role in extravasation. In the present study we used a human...

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Veröffentlicht in:	Immunology letters 2008-03, Vol.116 (2), p.218-224
Hauptverfasser:	Ben-David, Tal, Sagi-Assif, Orit, Meshel, Tsipi, Lifshitz, Veronica, Yron, Ilana, Witz, Isaac P
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Animals Cell Adhesion Cell Line, Tumor Colorectal carcinoma Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Down-Regulation E-Selectin - genetics E-Selectin - metabolism Experimental lung metastases Extravasation Female Fucosylated selectin ligands Gangliosides - metabolism Humans Ligands Mice Mice, Inbred BALB C Neoplasm Metastasis
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