Biglycan Is Required for Adaptive Remodeling After Myocardial Infarction

After myocardial infarction (MI), extensive remodeling of extracellular matrix contributes to scar formation and preservation of hemodynamic function. On the other hand, adverse and excessive extracellular matrix remodeling leads to fibrosis and impaired function. The present study investigates the...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2008-03, Vol.117 (10), p.1269-1276
Hauptverfasser:	WESTERMANN, D, MERSMANN, J, BRAND-HERRMANN, S.-M, YOUNG, M. F, SCHULTHEISS, H. P, LEVKAU, B, BABA, H. A, UNGER, T, ZACHAROWSKI, K, TSCHÖPE, C, FISCHER, J. W, MELCHIOR, A, FREUDENBERGER, T, PETRIK, C, SCHAEFER, L, LÜLLMANN-RAUCH, R, LETTAU, O, JACOBY, C, SCHRADER, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Biglycan Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Cicatrix Coronary heart disease Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Extracellular Matrix Proteins - deficiency Extracellular Matrix Proteins - genetics Extracellular Matrix Proteins - metabolism Genotype Heart Heart Rupture, Post-Infarction - metabolism Hemodynamics Humans Kaplan-Meier Estimate Medical sciences Mice Mice, Knockout Myocardial Infarction - metabolism Myocardial Infarction - mortality Myocardial Infarction - pathology Myocardial Infarction - physiopathology Myocardium - metabolism Myocardium - pathology Phenotype Proteoglycans - deficiency Proteoglycans - genetics Proteoglycans - metabolism Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism Ventricular Remodeling - physiology
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