Total Synthesis of Paecilomycine A

Total Synthesis of Paecilomycine A

Piecing together paecilomycine: The first total synthesis of paecilomycine A, a terpenoid that enhances nerve growth factor levels in certain human cells, has been achieved. Two highly stereoselective key steps in this concise route include an intermolecular Diels–Alder reaction and an intramolecula...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Angewandte Chemie International Edition 2007-01, Vol.46 (13), p.2199-2202
Hauptverfasser: Min, Sun-Joon, Danishefsky, Samuel J.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Diels-Alder reaction
Humans
Molecular Conformation
Molecular Structure
natural products
Nerve Growth Factors - chemical synthesis
Nerve Growth Factors - chemistry
Nerve Growth Factors - therapeutic use
Neurodegenerative Diseases - drug therapy
Paecilomyces - chemistry
Pauson-Khand reaction
PC12 Cells
Plant Extracts - chemistry
Plant Extracts - therapeutic use
Rats
Terpenes - chemical synthesis
Terpenes - chemistry
Terpenes - therapeutic use
total synthesis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Piecing together paecilomycine: The first total synthesis of paecilomycine A, a terpenoid that enhances nerve growth factor levels in certain human cells, has been achieved. Two highly stereoselective key steps in this concise route include an intermolecular Diels–Alder reaction and an intramolecular Pauson–Khand reaction (see scheme).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200605058