Selective loss of nigral dopamine neurons induced by overexpression of truncated human α-synuclein in mice

Abstract Parkinson's disease is characterized by loss of nigral dopaminergic neurons and presence of Lewy bodies, whose major component is α-synuclein. In the present study, we generated transgenic mice termed Syn130m that express truncated human α-synuclein (amino acid residue number: 1–130) i...

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