DNA damage and 2′-deoxyguanosine oxidation induced by S(IV) autoxidation catalyzed by copper(II) tetraglycine complexes: Synergistic effect of a second metal ion

S(IV) ( SO 2 , HSO 3 - and SO 3 2 - ) autoxidation catalyzed by Cu(II)/tetraglycine complexes in the presence of DNA or 2′-deoxyguanosine (dGuo) resulted in DNA strand breaks and formation of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo), respectively. Ni(II), Co(II) or Mn(II) (1.0 × 10 −4 M) comp...

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Veröffentlicht in:	Journal of inorganic biochemistry 2007-05, Vol.101 (5), p.866-875
Hauptverfasser:	Moreno, Ruben G.M., Alipázaga, María V., Gomes, Osmar F., Linares, Edlaine, Medeiros, Marisa H.G., Coichev, Nina
Format:	Artikel
Sprache:	eng
Schlagworte:	Copper Copper - chemistry Deoxyguanosine - chemistry DNA Damage Electron Spin Resonance Spectroscopy Electrophoresis, Agar Gel Oligopeptides - chemistry Organometallic Compounds - chemistry Oxidation-Reduction Spectrophotometry Sulfite Sulfur Dioxide - chemistry Synergistic effect Tetraglycine
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