DNA damage and 2′-deoxyguanosine oxidation induced by S(IV) autoxidation catalyzed by copper(II) tetraglycine complexes: Synergistic effect of a second metal ion
S(IV) ( SO 2 , HSO 3 - and SO 3 2 - ) autoxidation catalyzed by Cu(II)/tetraglycine complexes in the presence of DNA or 2′-deoxyguanosine (dGuo) resulted in DNA strand breaks and formation of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo), respectively. Ni(II), Co(II) or Mn(II) (1.0 × 10 −4 M) comp...
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| Veröffentlicht in: | Journal of inorganic biochemistry 2007-05, Vol.101 (5), p.866-875 |
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| container_title | Journal of inorganic biochemistry |
| container_volume | 101 |
| creator | Moreno, Ruben G.M. Alipázaga, María V. Gomes, Osmar F. Linares, Edlaine Medeiros, Marisa H.G. Coichev, Nina |
| description | S(IV)
(
SO
2
,
HSO
3
-
and
SO
3
2
-
)
autoxidation catalyzed by Cu(II)/tetraglycine complexes in the presence of DNA or 2′-deoxyguanosine (dGuo) resulted in DNA strand breaks and formation of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo), respectively. Ni(II), Co(II) or Mn(II) (1.0
×
10
−4
M) complexes had much smaller effects. Cu(II)/tetraglycine (1.0
×
10
−4
M) in the presence of Ni(II) or Mn(II) (10
−7–10
−6
M) and S(IV) showed remarkable synergistic effect with these metal ions producing a higher yield of 8-oxodGuo. Oxidation of dGuo and DNA damage were attributed to oxysulfur radicals formed as intermediates in S(IV) autoxidation catalyzed by transition metal ions.
SO
3
-
and HO
radicals were detected by EPR-spin trapping experiments with DMPO (5,5-dimethyl-1-pyrroline-
N-oxide). |
| doi_str_mv | 10.1016/j.jinorgbio.2007.02.003 |
| format | Article |
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(
SO
2
,
HSO
3
-
and
SO
3
2
-
)
autoxidation catalyzed by Cu(II)/tetraglycine complexes in the presence of DNA or 2′-deoxyguanosine (dGuo) resulted in DNA strand breaks and formation of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo), respectively. Ni(II), Co(II) or Mn(II) (1.0
×
10
−4
M) complexes had much smaller effects. Cu(II)/tetraglycine (1.0
×
10
−4
M) in the presence of Ni(II) or Mn(II) (10
−7–10
−6
M) and S(IV) showed remarkable synergistic effect with these metal ions producing a higher yield of 8-oxodGuo. Oxidation of dGuo and DNA damage were attributed to oxysulfur radicals formed as intermediates in S(IV) autoxidation catalyzed by transition metal ions.
SO
3
-
and HO
radicals were detected by EPR-spin trapping experiments with DMPO (5,5-dimethyl-1-pyrroline-
N-oxide).</description><identifier>ISSN: 0162-0134</identifier><identifier>EISSN: 1873-3344</identifier><identifier>DOI: 10.1016/j.jinorgbio.2007.02.003</identifier><identifier>PMID: 17383005</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Copper ; Copper - chemistry ; Deoxyguanosine - chemistry ; DNA Damage ; Electron Spin Resonance Spectroscopy ; Electrophoresis, Agar Gel ; Oligopeptides - chemistry ; Organometallic Compounds - chemistry ; Oxidation-Reduction ; Spectrophotometry ; Sulfite ; Sulfur Dioxide - chemistry ; Synergistic effect ; Tetraglycine</subject><ispartof>Journal of inorganic biochemistry, 2007-05, Vol.101 (5), p.866-875</ispartof><rights>2007 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c369t-ca86a30e38674dd6f62e9745f66b50eafa3aa47a5c82830c0afcda1b476532283</citedby><cites>FETCH-LOGICAL-c369t-ca86a30e38674dd6f62e9745f66b50eafa3aa47a5c82830c0afcda1b476532283</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.jinorgbio.2007.02.003$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17383005$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moreno, Ruben G.M.</creatorcontrib><creatorcontrib>Alipázaga, María V.</creatorcontrib><creatorcontrib>Gomes, Osmar F.</creatorcontrib><creatorcontrib>Linares, Edlaine</creatorcontrib><creatorcontrib>Medeiros, Marisa H.G.</creatorcontrib><creatorcontrib>Coichev, Nina</creatorcontrib><title>DNA damage and 2′-deoxyguanosine oxidation induced by S(IV) autoxidation catalyzed by copper(II) tetraglycine complexes: Synergistic effect of a second metal ion</title><title>Journal of inorganic biochemistry</title><addtitle>J Inorg Biochem</addtitle><description>S(IV)
(
SO
2
,
HSO
3
-
and
SO
3
2
-
)
autoxidation catalyzed by Cu(II)/tetraglycine complexes in the presence of DNA or 2′-deoxyguanosine (dGuo) resulted in DNA strand breaks and formation of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo), respectively. Ni(II), Co(II) or Mn(II) (1.0
×
10
−4
M) complexes had much smaller effects. Cu(II)/tetraglycine (1.0
×
10
−4
M) in the presence of Ni(II) or Mn(II) (10
−7–10
−6
M) and S(IV) showed remarkable synergistic effect with these metal ions producing a higher yield of 8-oxodGuo. Oxidation of dGuo and DNA damage were attributed to oxysulfur radicals formed as intermediates in S(IV) autoxidation catalyzed by transition metal ions.
SO
3
-
and HO
radicals were detected by EPR-spin trapping experiments with DMPO (5,5-dimethyl-1-pyrroline-
N-oxide).</description><subject>Copper</subject><subject>Copper - chemistry</subject><subject>Deoxyguanosine - chemistry</subject><subject>DNA Damage</subject><subject>Electron Spin Resonance Spectroscopy</subject><subject>Electrophoresis, Agar Gel</subject><subject>Oligopeptides - chemistry</subject><subject>Organometallic Compounds - chemistry</subject><subject>Oxidation-Reduction</subject><subject>Spectrophotometry</subject><subject>Sulfite</subject><subject>Sulfur Dioxide - chemistry</subject><subject>Synergistic effect</subject><subject>Tetraglycine</subject><issn>0162-0134</issn><issn>1873-3344</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9u1DAQxi1ERZfCK4BPqD0kOHYSZ7mtyp-uVJVDgas1sSeRV0kc7ARtOPEuvAGP1CfBq13RI6eRZ37zjWc-Ql5nLM1YVr7dpTs7ON_W1qWcMZkynjImnpBVVkmRCJHnT8kqkjxhmcjPyfMQdoyxosjlM3KeSVGJ-FqR3-_vNtRADy1SGAzlD7_-JAbdfmlnGFywA1K3twYm6wZqBzNrNLRe6P3l9tsVhXl6rGqYoFt-HuvajSP6y-32ik44eWi7RR_EtOvHDvcY3tH7ZUDf2jBZTbFpUE_UNRRoQO3iV3qMcjQKvyBnDXQBX57iBfn68cOX65vk9vOn7fXmNtGiXE-JhqoEwVBUpcyNKZuS41rmRVOWdcEQGhAAuYRCVzxurxk02kBW57IsBI-pC_LmqDt6933GMKneBo1dBwO6OSjJhORcriMoj6D2LgSPjRq97cEvKmPq4I_aqX_-qIM_inEV_Ymdr04j5rpH89h3MiQCmyOAcdEfFr0K2uIQj259PJAyzv53yF_CCKlV</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Moreno, Ruben G.M.</creator><creator>Alipázaga, María V.</creator><creator>Gomes, Osmar F.</creator><creator>Linares, Edlaine</creator><creator>Medeiros, Marisa H.G.</creator><creator>Coichev, Nina</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>DNA damage and 2′-deoxyguanosine oxidation induced by S(IV) autoxidation catalyzed by copper(II) tetraglycine complexes: Synergistic effect of a second metal ion</title><author>Moreno, Ruben G.M. ; Alipázaga, María V. ; Gomes, Osmar F. ; Linares, Edlaine ; Medeiros, Marisa H.G. ; Coichev, Nina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c369t-ca86a30e38674dd6f62e9745f66b50eafa3aa47a5c82830c0afcda1b476532283</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Copper</topic><topic>Copper - chemistry</topic><topic>Deoxyguanosine - chemistry</topic><topic>DNA Damage</topic><topic>Electron Spin Resonance Spectroscopy</topic><topic>Electrophoresis, Agar Gel</topic><topic>Oligopeptides - chemistry</topic><topic>Organometallic Compounds - chemistry</topic><topic>Oxidation-Reduction</topic><topic>Spectrophotometry</topic><topic>Sulfite</topic><topic>Sulfur Dioxide - chemistry</topic><topic>Synergistic effect</topic><topic>Tetraglycine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moreno, Ruben G.M.</creatorcontrib><creatorcontrib>Alipázaga, María V.</creatorcontrib><creatorcontrib>Gomes, Osmar F.</creatorcontrib><creatorcontrib>Linares, Edlaine</creatorcontrib><creatorcontrib>Medeiros, Marisa H.G.</creatorcontrib><creatorcontrib>Coichev, Nina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of inorganic biochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moreno, Ruben G.M.</au><au>Alipázaga, María V.</au><au>Gomes, Osmar F.</au><au>Linares, Edlaine</au><au>Medeiros, Marisa H.G.</au><au>Coichev, Nina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>DNA damage and 2′-deoxyguanosine oxidation induced by S(IV) autoxidation catalyzed by copper(II) tetraglycine complexes: Synergistic effect of a second metal ion</atitle><jtitle>Journal of inorganic biochemistry</jtitle><addtitle>J Inorg Biochem</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>101</volume><issue>5</issue><spage>866</spage><epage>875</epage><pages>866-875</pages><issn>0162-0134</issn><eissn>1873-3344</eissn><abstract>S(IV)
(
SO
2
,
HSO
3
-
and
SO
3
2
-
)
autoxidation catalyzed by Cu(II)/tetraglycine complexes in the presence of DNA or 2′-deoxyguanosine (dGuo) resulted in DNA strand breaks and formation of 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo), respectively. Ni(II), Co(II) or Mn(II) (1.0
×
10
−4
M) complexes had much smaller effects. Cu(II)/tetraglycine (1.0
×
10
−4
M) in the presence of Ni(II) or Mn(II) (10
−7–10
−6
M) and S(IV) showed remarkable synergistic effect with these metal ions producing a higher yield of 8-oxodGuo. Oxidation of dGuo and DNA damage were attributed to oxysulfur radicals formed as intermediates in S(IV) autoxidation catalyzed by transition metal ions.
SO
3
-
and HO
radicals were detected by EPR-spin trapping experiments with DMPO (5,5-dimethyl-1-pyrroline-
N-oxide).</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>17383005</pmid><doi>10.1016/j.jinorgbio.2007.02.003</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0162-0134 |
| ispartof | Journal of inorganic biochemistry, 2007-05, Vol.101 (5), p.866-875 |
| issn | 0162-0134 1873-3344 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70372279 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Copper Copper - chemistry Deoxyguanosine - chemistry DNA Damage Electron Spin Resonance Spectroscopy Electrophoresis, Agar Gel Oligopeptides - chemistry Organometallic Compounds - chemistry Oxidation-Reduction Spectrophotometry Sulfite Sulfur Dioxide - chemistry Synergistic effect Tetraglycine |
| title | DNA damage and 2′-deoxyguanosine oxidation induced by S(IV) autoxidation catalyzed by copper(II) tetraglycine complexes: Synergistic effect of a second metal ion |
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