Crosstalk between site-specific modifications on p53 and histone H3

Previously, we have observed a link between p53 expression and histone H3 post-translational modifications. Here, we ask if specific post-translational modifications of p53 impact upon histone H3 modifications in a selective manner. We have also screened for internal co-operative effects within the...

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Veröffentlicht in:	Oncogene 2008-03, Vol.27 (11), p.1639-1644
Hauptverfasser:	Warnock, L J, Adamson, R, Lynch, C J, Milner, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylation Alanine Apoptosis Aspartic acid Binding Sites Biological and medical sciences Cell Biology Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cellular biology Cellular signal transduction Chromatin Chromatin Immunoprecipitation Fundamental and applied biological sciences. Psychology Gene expression Genetic aspects HCT116 Cells Histone H3 Histones Histones - genetics Histones - metabolism Human Genetics Humans Internal Medicine Medicine Medicine & Public Health Molecular and cellular biology Mutants Mutation Oncology Phosphorylation Physiological aspects Post-translation Post-translational modification Proteins Serine - genetics Serine - metabolism short-communication Translation Tumor suppressor genes Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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