Growth Stimulation of Non–Small Cell Lung Cancer Cell Lines by Antibody against Epidermal Growth Factor Receptor Promoting Formation of ErbB2/ErbB3 Heterodimers

Antibodies are the most rapidly expanding class of human therapeutics, including their use in cancer therapy. Monoclonal antibodies (mAb) against epidermal growth factor (EGF) receptor (EGFR) generated for cancer therapy block the binding of ligand to various EGFR-expressing human cancer cell lines...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Molecular cancer research 2007-04, Vol.5 (4), p.393-401
Hauptverfasser:	Maegawa, Mari, Takeuchi, Kenji, Funakoshi, Eishi, Kawasaki, Katsumi, Nishio, Kazuto, Shimizu, Nobuyoshi, Ito, Fumiaki
Format:	Artikel
Sprache:	eng
Schlagworte:	anti-EGFR antibody Antibodies, Monoclonal - pharmacology Carcinoma, Non-Small-Cell Lung - immunology Cell Line, Tumor Cell Proliferation Dimerization Enzyme Activation epidermal growth factor receptor (EGFR) ErbB2 ErbB3 Gene Expression Regulation, Enzymologic Gene Expression Regulation, Neoplastic Humans Mitogen-Activated Protein Kinase 3 - metabolism Models, Biological Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Receptor, Epidermal Growth Factor - immunology Receptor, Epidermal Growth Factor - metabolism Receptor, ErbB-2 - metabolism Receptor, ErbB-3 - metabolism tyrosine kinase inhibitor
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!