IGF-II is present in bovine corneal stroma and activates keratocytes to proliferate in vitro

Extracts of bovine corneal stroma have been shown to activate keratocytes in culture to proliferate. We fractionated stromal extract on a column of Sephacryl S-300 and tested the fractions for mitogenic activity using cell culture and for the presence of IGF-II and its binding protein IGFBP-2 by Wes...

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Veröffentlicht in:	Experimental eye research 2008-03, Vol.86 (3), p.506-511
Hauptverfasser:	Musselmann, Kurt, Kane, Bradley P., Alexandrou, Bridgette, Hassell, John R.
Format:	Artikel
Sprache:	eng
Schlagworte:	activation Animals Blotting, Western - methods Cattle cell culture Cell Proliferation - drug effects Cells, Cultured Corneal Stroma - chemistry Corneal Stroma - cytology Corneal Stroma - drug effects Electrophoresis, Polyacrylamide Gel - methods IGF-II Insulin-Like Growth Factor Binding Protein 2 - analysis Insulin-Like Growth Factor II - analysis Insulin-Like Growth Factor II - pharmacology keratocyte myofibroblast proliferation TGF-β Transforming Growth Factor beta1 - pharmacology
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