High-field MRS study of GABA, glutamate and glutamine in social anxiety disorder: Response to treatment with levetiracetam

Abnormalities in brain gamma-aminobutyric acid (GABA) and glutamate may be relevant to the underlying pathophysiology of anxiety disorders including social anxiety disorder (SAD). We used proton magnetic resonance spectroscopy (pMRS) to examine whole brain and regional GABA, glutamate and glutamine...

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Veröffentlicht in:	Progress in neuro-psychopharmacology & biological psychiatry 2008-04, Vol.32 (3), p.739-743
Hauptverfasser:	Pollack, Mark H., Jensen, J. Eric, Simon, Naomi M., Kaufman, Rebecca E., Renshaw, Perry F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adult and adolescent clinical studies Aged Anxiety Disorders - diagnosis Anxiety Disorders - drug therapy Anxiety Disorders - metabolism Anxiety disorders. Neuroses Biological and medical sciences Female GABA gamma-Aminobutyric Acid - metabolism Glutamate Glutamic Acid - metabolism Glutamine - metabolism Humans Levetiracetam Magnetic Resonance Spectroscopy Male Medical sciences Middle Aged MRS Neuropharmacology Nootropic Agents - therapeutic use Pharmacology. Drug treatments Phobia Piracetam - analogs & derivatives Piracetam - therapeutic use Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Social anxiety
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