Neurochemical pathology in hippocampus in euthymic patients with bipolar I disorder

Objective: Subcortical regions such as hippocampus, thalamus and ventral putamen are assumed to be involved in the pathophysiology of mood regulation. Disturbed hippocampal neuronal function indicated by reduced N‐acetyl‐aspartate (NAA) levels in bipolar patients was shown by several studies. Resul...

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Veröffentlicht in:	Acta psychiatrica Scandinavica 2008-04, Vol.117 (4), p.283-288
Hauptverfasser:	Scherk, H., Backens, M., Schneider-Axmann, T., Kemmer, C., Usher, J., Reith, W., Falkai, P., Gruber, O.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adult and adolescent clinical studies Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Biochemistry Biological and medical sciences Bipolar disorder Bipolar Disorder - epidemiology Bipolar Disorder - metabolism Bipolar Disorder - physiopathology Bipolar disorders Choline - metabolism Creatine - metabolism Dysthymic Disorder - epidemiology Dysthymic Disorder - metabolism Dysthymic Disorder - physiopathology Female hippocampus Hippocampus - metabolism Hippocampus - physiopathology Humans Inositol - metabolism magnetic resonance spectroscopy Male Medical sciences Mood disorders N-acetyl-aspartate Neurology NMR Nuclear magnetic resonance Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Putamen - metabolism Putamen - physiopathology thalamus Thalamus - metabolism Thalamus - physiopathology
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