Neurochemical pathology in hippocampus in euthymic patients with bipolar I disorder
Objective: Subcortical regions such as hippocampus, thalamus and ventral putamen are assumed to be involved in the pathophysiology of mood regulation. Disturbed hippocampal neuronal function indicated by reduced N‐acetyl‐aspartate (NAA) levels in bipolar patients was shown by several studies. Resul...
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| Veröffentlicht in: | Acta psychiatrica Scandinavica 2008-04, Vol.117 (4), p.283-288 |
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| creator | Scherk, H. Backens, M. Schneider-Axmann, T. Kemmer, C. Usher, J. Reith, W. Falkai, P. Gruber, O. |
| description | Objective: Subcortical regions such as hippocampus, thalamus and ventral putamen are assumed to be involved in the pathophysiology of mood regulation. Disturbed hippocampal neuronal function indicated by reduced N‐acetyl‐aspartate (NAA) levels in bipolar patients was shown by several studies. Results in thalamus and putamen are inconsistent.
Method: N‐acetyl‐aspartate, choline (Cho), creatine (Cr) and myo‐inositol (Ins) were measured in left hippocampus, left thalamus and left putamen using proton magnetic resonance spectroscopy in 13 euthymic patients with bipolar I disorder and 13 pairwise matched healthy control subjects. Metabolic ratios NAA/Cr, NAA/Cho, Cho/Cr and Ins/Cr were calculated.
Results: Patients with bipolar I disorder demonstrated significantly reduced NAA/Cr in the left hippocampus compared with healthy control subjects. No alterations were found in thalamus or putamen.
Conclusion: We hypothesize that this NAA/Cr reduction might reflect neuronal dysfunction in the left hippocampus in patients with bipolar disorder. |
| doi_str_mv | 10.1111/j.1600-0447.2007.01142.x |
| format | Article |
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Method: N‐acetyl‐aspartate, choline (Cho), creatine (Cr) and myo‐inositol (Ins) were measured in left hippocampus, left thalamus and left putamen using proton magnetic resonance spectroscopy in 13 euthymic patients with bipolar I disorder and 13 pairwise matched healthy control subjects. Metabolic ratios NAA/Cr, NAA/Cho, Cho/Cr and Ins/Cr were calculated.
Results: Patients with bipolar I disorder demonstrated significantly reduced NAA/Cr in the left hippocampus compared with healthy control subjects. No alterations were found in thalamus or putamen.
Conclusion: We hypothesize that this NAA/Cr reduction might reflect neuronal dysfunction in the left hippocampus in patients with bipolar disorder.</description><identifier>ISSN: 0001-690X</identifier><identifier>EISSN: 1600-0447</identifier><identifier>DOI: 10.1111/j.1600-0447.2007.01142.x</identifier><identifier>PMID: 18205896</identifier><identifier>CODEN: APYSA9</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Adult and adolescent clinical studies ; Aspartic Acid - analogs & derivatives ; Aspartic Acid - metabolism ; Biochemistry ; Biological and medical sciences ; Bipolar disorder ; Bipolar Disorder - epidemiology ; Bipolar Disorder - metabolism ; Bipolar Disorder - physiopathology ; Bipolar disorders ; Choline - metabolism ; Creatine - metabolism ; Dysthymic Disorder - epidemiology ; Dysthymic Disorder - metabolism ; Dysthymic Disorder - physiopathology ; Female ; hippocampus ; Hippocampus - metabolism ; Hippocampus - physiopathology ; Humans ; Inositol - metabolism ; magnetic resonance spectroscopy ; Male ; Medical sciences ; Mood disorders ; N-acetyl-aspartate ; Neurology ; NMR ; Nuclear magnetic resonance ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Putamen - metabolism ; Putamen - physiopathology ; thalamus ; Thalamus - metabolism ; Thalamus - physiopathology</subject><ispartof>Acta psychiatrica Scandinavica, 2008-04, Vol.117 (4), p.283-288</ispartof><rights>2007 The Authors</rights><rights>2008 INIST-CNRS</rights><rights>Journal compilation © 2008 Blackwell Munksgaard</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4902-c70cfb597344f6bb67813eecb59276727c364211c1b1cdc3220f68f2b30444163</citedby><cites>FETCH-LOGICAL-c4902-c70cfb597344f6bb67813eecb59276727c364211c1b1cdc3220f68f2b30444163</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1600-0447.2007.01142.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1600-0447.2007.01142.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20214599$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/18205896$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Scherk, H.</creatorcontrib><creatorcontrib>Backens, M.</creatorcontrib><creatorcontrib>Schneider-Axmann, T.</creatorcontrib><creatorcontrib>Kemmer, C.</creatorcontrib><creatorcontrib>Usher, J.</creatorcontrib><creatorcontrib>Reith, W.</creatorcontrib><creatorcontrib>Falkai, P.</creatorcontrib><creatorcontrib>Gruber, O.</creatorcontrib><title>Neurochemical pathology in hippocampus in euthymic patients with bipolar I disorder</title><title>Acta psychiatrica Scandinavica</title><addtitle>Acta Psychiatr Scand</addtitle><description>Objective: Subcortical regions such as hippocampus, thalamus and ventral putamen are assumed to be involved in the pathophysiology of mood regulation. Disturbed hippocampal neuronal function indicated by reduced N‐acetyl‐aspartate (NAA) levels in bipolar patients was shown by several studies. Results in thalamus and putamen are inconsistent.
Method: N‐acetyl‐aspartate, choline (Cho), creatine (Cr) and myo‐inositol (Ins) were measured in left hippocampus, left thalamus and left putamen using proton magnetic resonance spectroscopy in 13 euthymic patients with bipolar I disorder and 13 pairwise matched healthy control subjects. Metabolic ratios NAA/Cr, NAA/Cho, Cho/Cr and Ins/Cr were calculated.
Results: Patients with bipolar I disorder demonstrated significantly reduced NAA/Cr in the left hippocampus compared with healthy control subjects. No alterations were found in thalamus or putamen.
Conclusion: We hypothesize that this NAA/Cr reduction might reflect neuronal dysfunction in the left hippocampus in patients with bipolar disorder.</description><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Aspartic Acid - analogs & derivatives</subject><subject>Aspartic Acid - metabolism</subject><subject>Biochemistry</subject><subject>Biological and medical sciences</subject><subject>Bipolar disorder</subject><subject>Bipolar Disorder - epidemiology</subject><subject>Bipolar Disorder - metabolism</subject><subject>Bipolar Disorder - physiopathology</subject><subject>Bipolar disorders</subject><subject>Choline - metabolism</subject><subject>Creatine - metabolism</subject><subject>Dysthymic Disorder - epidemiology</subject><subject>Dysthymic Disorder - metabolism</subject><subject>Dysthymic Disorder - physiopathology</subject><subject>Female</subject><subject>hippocampus</subject><subject>Hippocampus - metabolism</subject><subject>Hippocampus - physiopathology</subject><subject>Humans</subject><subject>Inositol - metabolism</subject><subject>magnetic resonance spectroscopy</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mood disorders</subject><subject>N-acetyl-aspartate</subject><subject>Neurology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Putamen - metabolism</subject><subject>Putamen - physiopathology</subject><subject>thalamus</subject><subject>Thalamus - metabolism</subject><subject>Thalamus - physiopathology</subject><issn>0001-690X</issn><issn>1600-0447</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkdFu0zAUhi0EYt3gFVCEBHcJPrZjJzdIU4ExMQ1Qh7Y7y3Ed4pLEmZ1o7dvPoVWRuAHf2Mf-zq9jfQglgDOI690mA45xihkTGcFYZBiAkWz7BC2OD0_RAmMMKS_x3Qk6DWETyxxw8RydQEFwXpR8gVbXZvJON6azWrXJoMbGte7nLrF90thhcFp1wxTm0kxjs4vYDFnTjyF5sGOTVHZwrfLJZbK2wfm18S_Qs1q1wbw87Gfox6ePN8vP6dXXi8vl-VWqWYlJqgXWdZWXgjJW86riogBqjI5XRHBBhKacEQANFei1poTgmhc1qWj8HgNOz9Dbfe7g3f1kwig7G7RpW9UbNwUpMOUFZRDB13-BGzf5Ps4mocwLLkr4J8QKTosIFXtIexeCN7UcvO2U30nAclYjN3I2IGcDclYjf6uR29j66pA_VZ1Z_2k8uIjAmwOgQnRRe9VrG44cwQRYXpaRe7_nHmxrdv89gDxfflvNxxiQ7gNsGM32GKD8L8kFFbm8vb6IcXcfVrdfbuR3-ghc6bdX</recordid><startdate>200804</startdate><enddate>200804</enddate><creator>Scherk, H.</creator><creator>Backens, M.</creator><creator>Schneider-Axmann, T.</creator><creator>Kemmer, C.</creator><creator>Usher, J.</creator><creator>Reith, W.</creator><creator>Falkai, P.</creator><creator>Gruber, O.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>200804</creationdate><title>Neurochemical pathology in hippocampus in euthymic patients with bipolar I disorder</title><author>Scherk, H. ; Backens, M. ; Schneider-Axmann, T. ; Kemmer, C. ; Usher, J. ; Reith, W. ; Falkai, P. ; Gruber, O.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4902-c70cfb597344f6bb67813eecb59276727c364211c1b1cdc3220f68f2b30444163</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Aspartic Acid - analogs & derivatives</topic><topic>Aspartic Acid - metabolism</topic><topic>Biochemistry</topic><topic>Biological and medical sciences</topic><topic>Bipolar disorder</topic><topic>Bipolar Disorder - epidemiology</topic><topic>Bipolar Disorder - metabolism</topic><topic>Bipolar Disorder - physiopathology</topic><topic>Bipolar disorders</topic><topic>Choline - metabolism</topic><topic>Creatine - metabolism</topic><topic>Dysthymic Disorder - epidemiology</topic><topic>Dysthymic Disorder - metabolism</topic><topic>Dysthymic Disorder - physiopathology</topic><topic>Female</topic><topic>hippocampus</topic><topic>Hippocampus - metabolism</topic><topic>Hippocampus - physiopathology</topic><topic>Humans</topic><topic>Inositol - metabolism</topic><topic>magnetic resonance spectroscopy</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mood disorders</topic><topic>N-acetyl-aspartate</topic><topic>Neurology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Putamen - metabolism</topic><topic>Putamen - physiopathology</topic><topic>thalamus</topic><topic>Thalamus - metabolism</topic><topic>Thalamus - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scherk, H.</creatorcontrib><creatorcontrib>Backens, M.</creatorcontrib><creatorcontrib>Schneider-Axmann, T.</creatorcontrib><creatorcontrib>Kemmer, C.</creatorcontrib><creatorcontrib>Usher, J.</creatorcontrib><creatorcontrib>Reith, W.</creatorcontrib><creatorcontrib>Falkai, P.</creatorcontrib><creatorcontrib>Gruber, O.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Acta psychiatrica Scandinavica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scherk, H.</au><au>Backens, M.</au><au>Schneider-Axmann, T.</au><au>Kemmer, C.</au><au>Usher, J.</au><au>Reith, W.</au><au>Falkai, P.</au><au>Gruber, O.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neurochemical pathology in hippocampus in euthymic patients with bipolar I disorder</atitle><jtitle>Acta psychiatrica Scandinavica</jtitle><addtitle>Acta Psychiatr Scand</addtitle><date>2008-04</date><risdate>2008</risdate><volume>117</volume><issue>4</issue><spage>283</spage><epage>288</epage><pages>283-288</pages><issn>0001-690X</issn><eissn>1600-0447</eissn><coden>APYSA9</coden><abstract>Objective: Subcortical regions such as hippocampus, thalamus and ventral putamen are assumed to be involved in the pathophysiology of mood regulation. Disturbed hippocampal neuronal function indicated by reduced N‐acetyl‐aspartate (NAA) levels in bipolar patients was shown by several studies. Results in thalamus and putamen are inconsistent.
Method: N‐acetyl‐aspartate, choline (Cho), creatine (Cr) and myo‐inositol (Ins) were measured in left hippocampus, left thalamus and left putamen using proton magnetic resonance spectroscopy in 13 euthymic patients with bipolar I disorder and 13 pairwise matched healthy control subjects. Metabolic ratios NAA/Cr, NAA/Cho, Cho/Cr and Ins/Cr were calculated.
Results: Patients with bipolar I disorder demonstrated significantly reduced NAA/Cr in the left hippocampus compared with healthy control subjects. No alterations were found in thalamus or putamen.
Conclusion: We hypothesize that this NAA/Cr reduction might reflect neuronal dysfunction in the left hippocampus in patients with bipolar disorder.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>18205896</pmid><doi>10.1111/j.1600-0447.2007.01142.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Acta psychiatrica Scandinavica, 2008-04, Vol.117 (4), p.283-288 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Adult and adolescent clinical studies Aspartic Acid - analogs & derivatives Aspartic Acid - metabolism Biochemistry Biological and medical sciences Bipolar disorder Bipolar Disorder - epidemiology Bipolar Disorder - metabolism Bipolar Disorder - physiopathology Bipolar disorders Choline - metabolism Creatine - metabolism Dysthymic Disorder - epidemiology Dysthymic Disorder - metabolism Dysthymic Disorder - physiopathology Female hippocampus Hippocampus - metabolism Hippocampus - physiopathology Humans Inositol - metabolism magnetic resonance spectroscopy Male Medical sciences Mood disorders N-acetyl-aspartate Neurology NMR Nuclear magnetic resonance Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Putamen - metabolism Putamen - physiopathology thalamus Thalamus - metabolism Thalamus - physiopathology |
| title | Neurochemical pathology in hippocampus in euthymic patients with bipolar I disorder |
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