Cutaneous metastasis of occult hepatocellular carcinoma : A case report
Skin metastases from hepatocellular carcinoma (HCC) represented only 0.8% of all known cutaneous metastases in a recent large series. The most frequent site appears to be the head, but this fact has received little attention. An accurate cytologic diagnosis is extremely difficult in patients with un...
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| Veröffentlicht in: | Acta cytologica 2007-03, Vol.51 (2), p.214-216 |
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| creator | DE AGUSTIN, Pedro CONDE, Esther ALBERTI, Nuria PEREZ-BARRIOS, Andrés LOPEZ-RIOS, Fernando |
| description | Skin metastases from hepatocellular carcinoma (HCC) represented only 0.8% of all known cutaneous metastases in a recent large series. The most frequent site appears to be the head, but this fact has received little attention. An accurate cytologic diagnosis is extremely difficult in patients with unknown liver dysfunction. We report the cytologic features of a face metastasis from occult HCC.
A 65-year-old woman presented with a mass in the right preauricular region of 2 months' duration. Her past medical history was noncontributory. Fine needle aspiration cytology was performed. Following the cytologic diagnosis, computed tomography revealed a 6-cm mass in the right lobe of the liver, portal vein thrombosis and involvement of the superior vena cava. The smears were very cellular. The most frequent pattern was trabecular with transmural endothelization. The cells had an epithelial appearance and polyhedral shape, exhibiting distinct borders. The nuclei were centrally placed, with a prominent nucleolus. The cytoplasm was granular. There were numerous atypical bare nuclei. Subsequent staining with antihepatocyte showed positivity in most tumor cells. The final diagnosis was metastatic HCC.
HCCs should be considered in the differential diagnosis of carcinomas metastatic to the face, even in the absence of liver symptoms. |
| doi_str_mv | 10.1159/000325720 |
| format | Article |
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A 65-year-old woman presented with a mass in the right preauricular region of 2 months' duration. Her past medical history was noncontributory. Fine needle aspiration cytology was performed. Following the cytologic diagnosis, computed tomography revealed a 6-cm mass in the right lobe of the liver, portal vein thrombosis and involvement of the superior vena cava. The smears were very cellular. The most frequent pattern was trabecular with transmural endothelization. The cells had an epithelial appearance and polyhedral shape, exhibiting distinct borders. The nuclei were centrally placed, with a prominent nucleolus. The cytoplasm was granular. There were numerous atypical bare nuclei. Subsequent staining with antihepatocyte showed positivity in most tumor cells. The final diagnosis was metastatic HCC.
HCCs should be considered in the differential diagnosis of carcinomas metastatic to the face, even in the absence of liver symptoms.</description><identifier>ISSN: 0001-5547</identifier><identifier>EISSN: 1938-2650</identifier><identifier>DOI: 10.1159/000325720</identifier><identifier>PMID: 17425207</identifier><identifier>CODEN: ACYTAN</identifier><language>eng</language><publisher>St. Louis, MO: Science Printers and Publishers</publisher><subject>Aged ; Biological and medical sciences ; Biopsy, Fine-Needle ; Carcinoma, Hepatocellular - diagnosis ; Carcinoma, Hepatocellular - secondary ; Dermatology ; Female ; Hepatitis B - complications ; Hepatitis C - complications ; Humans ; Hypertension, Portal - etiology ; Hypertension, Portal - physiopathology ; Investigative techniques, diagnostic techniques (general aspects) ; Liver - diagnostic imaging ; Liver - pathology ; Liver - physiopathology ; Liver Cirrhosis - complications ; Liver Neoplasms - complications ; Liver Neoplasms - diagnostic imaging ; Liver Neoplasms - pathology ; Medical sciences ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; Portal Vein - pathology ; Portal Vein - physiopathology ; Skin - pathology ; Skin - physiopathology ; Skin Neoplasms - diagnosis ; Skin Neoplasms - secondary ; Tomography, X-Ray Computed ; Tumors of the skin and soft tissue. Premalignant lesions</subject><ispartof>Acta cytologica, 2007-03, Vol.51 (2), p.214-216</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18626825$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17425207$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>DE AGUSTIN, Pedro</creatorcontrib><creatorcontrib>CONDE, Esther</creatorcontrib><creatorcontrib>ALBERTI, Nuria</creatorcontrib><creatorcontrib>PEREZ-BARRIOS, Andrés</creatorcontrib><creatorcontrib>LOPEZ-RIOS, Fernando</creatorcontrib><title>Cutaneous metastasis of occult hepatocellular carcinoma : A case report</title><title>Acta cytologica</title><addtitle>Acta Cytol</addtitle><description>Skin metastases from hepatocellular carcinoma (HCC) represented only 0.8% of all known cutaneous metastases in a recent large series. The most frequent site appears to be the head, but this fact has received little attention. An accurate cytologic diagnosis is extremely difficult in patients with unknown liver dysfunction. We report the cytologic features of a face metastasis from occult HCC.
A 65-year-old woman presented with a mass in the right preauricular region of 2 months' duration. Her past medical history was noncontributory. Fine needle aspiration cytology was performed. Following the cytologic diagnosis, computed tomography revealed a 6-cm mass in the right lobe of the liver, portal vein thrombosis and involvement of the superior vena cava. The smears were very cellular. The most frequent pattern was trabecular with transmural endothelization. The cells had an epithelial appearance and polyhedral shape, exhibiting distinct borders. The nuclei were centrally placed, with a prominent nucleolus. The cytoplasm was granular. There were numerous atypical bare nuclei. Subsequent staining with antihepatocyte showed positivity in most tumor cells. The final diagnosis was metastatic HCC.
HCCs should be considered in the differential diagnosis of carcinomas metastatic to the face, even in the absence of liver symptoms.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Biopsy, Fine-Needle</subject><subject>Carcinoma, Hepatocellular - diagnosis</subject><subject>Carcinoma, Hepatocellular - secondary</subject><subject>Dermatology</subject><subject>Female</subject><subject>Hepatitis B - complications</subject><subject>Hepatitis C - complications</subject><subject>Humans</subject><subject>Hypertension, Portal - etiology</subject><subject>Hypertension, Portal - physiopathology</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Liver - diagnostic imaging</subject><subject>Liver - pathology</subject><subject>Liver - physiopathology</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver Neoplasms - complications</subject><subject>Liver Neoplasms - diagnostic imaging</subject><subject>Liver Neoplasms - pathology</subject><subject>Medical sciences</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</subject><subject>Portal Vein - pathology</subject><subject>Portal Vein - physiopathology</subject><subject>Skin - pathology</subject><subject>Skin - physiopathology</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - secondary</subject><subject>Tomography, X-Ray Computed</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0001-5547</issn><issn>1938-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFz01LAzEQBuAgiq3Vg39ActHb6uRrJ-utFK1CwYuelyTN4spusybZg__eLa0IA8MMD8O8hFwzuGdMVQ8AILhCDidkziqhC14qOCXzac8KpSTOyEVKX5MSZSnOyYyh5IoDzsl6NWaz82FMtPfZpKnaRENDg3Njl-mnH0wOznfd2JlInYmu3YXe0Ee6nKbkafRDiPmSnDWmS_7q2Bfk4_npffVSbN7Wr6vlphi4qHKhrd02svIWNFjkDQgJylsuUdqKey2lAMnRKYsIRiPjoJVG26AA3DohFuTucHeI4Xv0Kdd9m_bvHULUCKJE0GyCN0c42t5v6yG2vYk_9V_0CdwegUnOdE00O9emf6dLXmquxC8FGWUf</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>DE AGUSTIN, Pedro</creator><creator>CONDE, Esther</creator><creator>ALBERTI, Nuria</creator><creator>PEREZ-BARRIOS, Andrés</creator><creator>LOPEZ-RIOS, Fernando</creator><general>Science Printers and Publishers</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20070301</creationdate><title>Cutaneous metastasis of occult hepatocellular carcinoma : A case report</title><author>DE AGUSTIN, Pedro ; CONDE, Esther ; ALBERTI, Nuria ; PEREZ-BARRIOS, Andrés ; LOPEZ-RIOS, Fernando</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p239t-8bbdf49eb080b72f03405eb2474b92e84430427c5b770a871208587bf7307dc33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Biopsy, Fine-Needle</topic><topic>Carcinoma, Hepatocellular - diagnosis</topic><topic>Carcinoma, Hepatocellular - secondary</topic><topic>Dermatology</topic><topic>Female</topic><topic>Hepatitis B - complications</topic><topic>Hepatitis C - complications</topic><topic>Humans</topic><topic>Hypertension, Portal - etiology</topic><topic>Hypertension, Portal - physiopathology</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Liver - diagnostic imaging</topic><topic>Liver - pathology</topic><topic>Liver - physiopathology</topic><topic>Liver Cirrhosis - complications</topic><topic>Liver Neoplasms - complications</topic><topic>Liver Neoplasms - diagnostic imaging</topic><topic>Liver Neoplasms - pathology</topic><topic>Medical sciences</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques</topic><topic>Portal Vein - pathology</topic><topic>Portal Vein - physiopathology</topic><topic>Skin - pathology</topic><topic>Skin - physiopathology</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - secondary</topic><topic>Tomography, X-Ray Computed</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>DE AGUSTIN, Pedro</creatorcontrib><creatorcontrib>CONDE, Esther</creatorcontrib><creatorcontrib>ALBERTI, Nuria</creatorcontrib><creatorcontrib>PEREZ-BARRIOS, Andrés</creatorcontrib><creatorcontrib>LOPEZ-RIOS, Fernando</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Acta cytologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>DE AGUSTIN, Pedro</au><au>CONDE, Esther</au><au>ALBERTI, Nuria</au><au>PEREZ-BARRIOS, Andrés</au><au>LOPEZ-RIOS, Fernando</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cutaneous metastasis of occult hepatocellular carcinoma : A case report</atitle><jtitle>Acta cytologica</jtitle><addtitle>Acta Cytol</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>51</volume><issue>2</issue><spage>214</spage><epage>216</epage><pages>214-216</pages><issn>0001-5547</issn><eissn>1938-2650</eissn><coden>ACYTAN</coden><abstract>Skin metastases from hepatocellular carcinoma (HCC) represented only 0.8% of all known cutaneous metastases in a recent large series. The most frequent site appears to be the head, but this fact has received little attention. An accurate cytologic diagnosis is extremely difficult in patients with unknown liver dysfunction. We report the cytologic features of a face metastasis from occult HCC.
A 65-year-old woman presented with a mass in the right preauricular region of 2 months' duration. Her past medical history was noncontributory. Fine needle aspiration cytology was performed. Following the cytologic diagnosis, computed tomography revealed a 6-cm mass in the right lobe of the liver, portal vein thrombosis and involvement of the superior vena cava. The smears were very cellular. The most frequent pattern was trabecular with transmural endothelization. The cells had an epithelial appearance and polyhedral shape, exhibiting distinct borders. The nuclei were centrally placed, with a prominent nucleolus. The cytoplasm was granular. There were numerous atypical bare nuclei. Subsequent staining with antihepatocyte showed positivity in most tumor cells. The final diagnosis was metastatic HCC.
HCCs should be considered in the differential diagnosis of carcinomas metastatic to the face, even in the absence of liver symptoms.</abstract><cop>St. Louis, MO</cop><pub>Science Printers and Publishers</pub><pmid>17425207</pmid><doi>10.1159/000325720</doi><tpages>3</tpages></addata></record> |
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| subjects | Aged Biological and medical sciences Biopsy, Fine-Needle Carcinoma, Hepatocellular - diagnosis Carcinoma, Hepatocellular - secondary Dermatology Female Hepatitis B - complications Hepatitis C - complications Humans Hypertension, Portal - etiology Hypertension, Portal - physiopathology Investigative techniques, diagnostic techniques (general aspects) Liver - diagnostic imaging Liver - pathology Liver - physiopathology Liver Cirrhosis - complications Liver Neoplasms - complications Liver Neoplasms - diagnostic imaging Liver Neoplasms - pathology Medical sciences Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques Portal Vein - pathology Portal Vein - physiopathology Skin - pathology Skin - physiopathology Skin Neoplasms - diagnosis Skin Neoplasms - secondary Tomography, X-Ray Computed Tumors of the skin and soft tissue. Premalignant lesions |
| title | Cutaneous metastasis of occult hepatocellular carcinoma : A case report |
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