INDUCTION OF BIVALENT IMMUNE RESPONSES BY EXPRESSION OF DENGUE VIRUS TYPE 1 AND TYPE 2 ANTIGENS FROM A SINGLE COMPLEX ADENOVIRAL VECTOR
There are approximately 100 million new cases of dengue (DEN) virus infection each year. Infection can result in illness ranging from a mild fever to hemorrhaging, shock, or even death. There are four serotypes of dengue virus (DEN1-4), and immunity to one serotype does not cross protect from infect...
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| Veröffentlicht in: | The American journal of tropical medicine and hygiene 2007-04, Vol.76 (4), p.743-751 |
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| creator | RAJA, NICHOLAS U HOLMAN, DAVID H WANG, DANHER RAVIPRAKASH, KANAKATTE JUOMPAN, LAURE Y DEITZ, STEPHEN B LUO, MIN ZHANG, JIANGHUI PORTER, KEVIN R DONG, JOHN Y |
| description | There are approximately 100 million new cases of dengue (DEN) virus infection each year. Infection can result in illness ranging from a mild fever to hemorrhaging, shock, or even death. There are four serotypes of dengue virus (DEN1-4), and immunity to one serotype does not cross protect from infection with other serotypes. Currently there are no approved vaccines for dengue fever. In this report, we describe the construction of a bivalent dengue virus vaccine using a complex recombinant adenovirus approach to express multiple genes of DEN1 and DEN2 serotypes. In vaccinated mice, this vector induced humoral immune responses against all four dengue serotypes as measured by enzyme-linked immunosorbent assay. However, the neutralizing antibody responses were specific for DEN1 and DEN2 serotypes. Expansion of this vaccine development platform towards the DEN3 and DEN4 serotypes can lead towards the development of an adenovirus-based tetravalent dengue vaccine. |
| doi_str_mv | 10.4269/ajtmh.2007.76.743 |
| format | Article |
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Infection can result in illness ranging from a mild fever to hemorrhaging, shock, or even death. There are four serotypes of dengue virus (DEN1-4), and immunity to one serotype does not cross protect from infection with other serotypes. Currently there are no approved vaccines for dengue fever. In this report, we describe the construction of a bivalent dengue virus vaccine using a complex recombinant adenovirus approach to express multiple genes of DEN1 and DEN2 serotypes. In vaccinated mice, this vector induced humoral immune responses against all four dengue serotypes as measured by enzyme-linked immunosorbent assay. However, the neutralizing antibody responses were specific for DEN1 and DEN2 serotypes. Expansion of this vaccine development platform towards the DEN3 and DEN4 serotypes can lead towards the development of an adenovirus-based tetravalent dengue vaccine.</description><identifier>ISSN: 0002-9637</identifier><identifier>EISSN: 1476-1645</identifier><identifier>DOI: 10.4269/ajtmh.2007.76.743</identifier><identifier>PMID: 17426182</identifier><identifier>CODEN: AJTHAB</identifier><language>eng</language><publisher>Lawrence, KS: ASTMH</publisher><subject>Adenoviridae - genetics ; Adenovirus ; Animals ; Antigens, Viral - genetics ; Antigens, Viral - immunology ; Biological and medical sciences ; Cell Line ; Cercopithecus aethiops ; Dengue - immunology ; Dengue - virology ; Dengue Virus - genetics ; Dengue Virus - immunology ; Dengue virus type 1 ; Gene Expression ; Humans ; Infectious diseases ; Medical sciences ; Mice ; Vero Cells ; Viral Vaccines - genetics ; Viral Vaccines - immunology</subject><ispartof>The American journal of tropical medicine and hygiene, 2007-04, Vol.76 (4), p.743-751</ispartof><rights>2007 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c433t-c970cadcef3df16cd6f3d248555e8fff456ed8f7323fe3d44caa075fb43eafdb3</citedby><cites>FETCH-LOGICAL-c433t-c970cadcef3df16cd6f3d248555e8fff456ed8f7323fe3d44caa075fb43eafdb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18690614$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17426182$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>RAJA, NICHOLAS U</creatorcontrib><creatorcontrib>HOLMAN, DAVID H</creatorcontrib><creatorcontrib>WANG, DANHER</creatorcontrib><creatorcontrib>RAVIPRAKASH, KANAKATTE</creatorcontrib><creatorcontrib>JUOMPAN, LAURE Y</creatorcontrib><creatorcontrib>DEITZ, STEPHEN B</creatorcontrib><creatorcontrib>LUO, MIN</creatorcontrib><creatorcontrib>ZHANG, JIANGHUI</creatorcontrib><creatorcontrib>PORTER, KEVIN R</creatorcontrib><creatorcontrib>DONG, JOHN Y</creatorcontrib><title>INDUCTION OF BIVALENT IMMUNE RESPONSES BY EXPRESSION OF DENGUE VIRUS TYPE 1 AND TYPE 2 ANTIGENS FROM A SINGLE COMPLEX ADENOVIRAL VECTOR</title><title>The American journal of tropical medicine and hygiene</title><addtitle>Am J Trop Med Hyg</addtitle><description>There are approximately 100 million new cases of dengue (DEN) virus infection each year. Infection can result in illness ranging from a mild fever to hemorrhaging, shock, or even death. There are four serotypes of dengue virus (DEN1-4), and immunity to one serotype does not cross protect from infection with other serotypes. Currently there are no approved vaccines for dengue fever. In this report, we describe the construction of a bivalent dengue virus vaccine using a complex recombinant adenovirus approach to express multiple genes of DEN1 and DEN2 serotypes. In vaccinated mice, this vector induced humoral immune responses against all four dengue serotypes as measured by enzyme-linked immunosorbent assay. However, the neutralizing antibody responses were specific for DEN1 and DEN2 serotypes. Expansion of this vaccine development platform towards the DEN3 and DEN4 serotypes can lead towards the development of an adenovirus-based tetravalent dengue vaccine.</description><subject>Adenoviridae - genetics</subject><subject>Adenovirus</subject><subject>Animals</subject><subject>Antigens, Viral - genetics</subject><subject>Antigens, Viral - immunology</subject><subject>Biological and medical sciences</subject><subject>Cell Line</subject><subject>Cercopithecus aethiops</subject><subject>Dengue - immunology</subject><subject>Dengue - virology</subject><subject>Dengue Virus - genetics</subject><subject>Dengue Virus - immunology</subject><subject>Dengue virus type 1</subject><subject>Gene Expression</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Vero Cells</subject><subject>Viral Vaccines - genetics</subject><subject>Viral Vaccines - immunology</subject><issn>0002-9637</issn><issn>1476-1645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUFvmzAcxdG0ac26fYBdJl-2G5mNjQ1HSpwMiUAUIGpPlgP2QgVNixNF_QT92nMapBx3-r-_9HvvHZ7jfEdwSjwa_paPh3439SBkU0anjOAPzgQRRl1Eif_RmUAIPTekmN04X4x5hBAFHkKfnRvErN8-E-ctyWZVXCZ5BvI5uEs2UcqzEiTLZZVxsObFKs8KXoC7B8DvV_YvRnTGs0XFwSZZVwUoH1YcIBBls4v0rCyTBc8KMF_nSxCBIskWKQdxvlyl_B5E1p5bb5SCDY_LfP3V-aRlZ9S38d461ZyX8R83zRdJHKVuTTA-uHXIYC2bWmncaETrhlrhkcD3fRVorYlPVRNohj2sFW4IqaWEzNdbgpXUzRbfOr8uuc_D_uWozEH0ralV18kntT8awSCmfgjRf0EU-iyg_hlEF7Ae9sYMSovnoe3l8CoQFOeZxPtM4jyTYFTYmaznxxh-3PaquTrGXSzwcwSkqWWnB_lUt-bKBTSEFJErt2v_7k7toITpZdfZWCROp5OtI--F_wBkAp8E</recordid><startdate>20070401</startdate><enddate>20070401</enddate><creator>RAJA, NICHOLAS U</creator><creator>HOLMAN, DAVID H</creator><creator>WANG, DANHER</creator><creator>RAVIPRAKASH, KANAKATTE</creator><creator>JUOMPAN, LAURE Y</creator><creator>DEITZ, STEPHEN B</creator><creator>LUO, MIN</creator><creator>ZHANG, JIANGHUI</creator><creator>PORTER, KEVIN R</creator><creator>DONG, JOHN Y</creator><general>ASTMH</general><general>Allen Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20070401</creationdate><title>INDUCTION OF BIVALENT IMMUNE RESPONSES BY EXPRESSION OF DENGUE VIRUS TYPE 1 AND TYPE 2 ANTIGENS FROM A SINGLE COMPLEX ADENOVIRAL VECTOR</title><author>RAJA, NICHOLAS U ; HOLMAN, DAVID H ; WANG, DANHER ; RAVIPRAKASH, KANAKATTE ; JUOMPAN, LAURE Y ; DEITZ, STEPHEN B ; LUO, MIN ; ZHANG, JIANGHUI ; PORTER, KEVIN R ; DONG, JOHN Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c433t-c970cadcef3df16cd6f3d248555e8fff456ed8f7323fe3d44caa075fb43eafdb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Adenoviridae - genetics</topic><topic>Adenovirus</topic><topic>Animals</topic><topic>Antigens, Viral - genetics</topic><topic>Antigens, Viral - immunology</topic><topic>Biological and medical sciences</topic><topic>Cell Line</topic><topic>Cercopithecus aethiops</topic><topic>Dengue - immunology</topic><topic>Dengue - virology</topic><topic>Dengue Virus - genetics</topic><topic>Dengue Virus - immunology</topic><topic>Dengue virus type 1</topic><topic>Gene Expression</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Vero Cells</topic><topic>Viral Vaccines - genetics</topic><topic>Viral Vaccines - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>RAJA, NICHOLAS U</creatorcontrib><creatorcontrib>HOLMAN, DAVID H</creatorcontrib><creatorcontrib>WANG, DANHER</creatorcontrib><creatorcontrib>RAVIPRAKASH, KANAKATTE</creatorcontrib><creatorcontrib>JUOMPAN, LAURE Y</creatorcontrib><creatorcontrib>DEITZ, STEPHEN B</creatorcontrib><creatorcontrib>LUO, MIN</creatorcontrib><creatorcontrib>ZHANG, JIANGHUI</creatorcontrib><creatorcontrib>PORTER, KEVIN R</creatorcontrib><creatorcontrib>DONG, JOHN Y</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of tropical medicine and hygiene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>RAJA, NICHOLAS U</au><au>HOLMAN, DAVID H</au><au>WANG, DANHER</au><au>RAVIPRAKASH, KANAKATTE</au><au>JUOMPAN, LAURE Y</au><au>DEITZ, STEPHEN B</au><au>LUO, MIN</au><au>ZHANG, JIANGHUI</au><au>PORTER, KEVIN R</au><au>DONG, JOHN Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>INDUCTION OF BIVALENT IMMUNE RESPONSES BY EXPRESSION OF DENGUE VIRUS TYPE 1 AND TYPE 2 ANTIGENS FROM A SINGLE COMPLEX ADENOVIRAL VECTOR</atitle><jtitle>The American journal of tropical medicine and hygiene</jtitle><addtitle>Am J Trop Med Hyg</addtitle><date>2007-04-01</date><risdate>2007</risdate><volume>76</volume><issue>4</issue><spage>743</spage><epage>751</epage><pages>743-751</pages><issn>0002-9637</issn><eissn>1476-1645</eissn><coden>AJTHAB</coden><abstract>There are approximately 100 million new cases of dengue (DEN) virus infection each year. 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| subjects | Adenoviridae - genetics Adenovirus Animals Antigens, Viral - genetics Antigens, Viral - immunology Biological and medical sciences Cell Line Cercopithecus aethiops Dengue - immunology Dengue - virology Dengue Virus - genetics Dengue Virus - immunology Dengue virus type 1 Gene Expression Humans Infectious diseases Medical sciences Mice Vero Cells Viral Vaccines - genetics Viral Vaccines - immunology |
| title | INDUCTION OF BIVALENT IMMUNE RESPONSES BY EXPRESSION OF DENGUE VIRUS TYPE 1 AND TYPE 2 ANTIGENS FROM A SINGLE COMPLEX ADENOVIRAL VECTOR |
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