Numerical Modeling of Odorant Uptake in the Rat Nasal Cavity
An anatomically accurate 3-dimensional numerical model of the right rat nasal cavity was developed and used to compute low, medium, and high flow rate inspiratory and expiratory mucosal odorant uptake (imposed patterning) for 3 odorants with different mucus solubilities. The computed surface mass fl...
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| Veröffentlicht in: | Chemical senses 2007-03, Vol.32 (3), p.273-284 |
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| creator | Yang, Geoffrey C. Scherer, Peter W. Zhao, Kai Mozell, Maxwell M. |
| description | An anatomically accurate 3-dimensional numerical model of the right rat nasal cavity was developed and used to compute low, medium, and high flow rate inspiratory and expiratory mucosal odorant uptake (imposed patterning) for 3 odorants with different mucus solubilities. The computed surface mass flux distributions were compared with anatomic receptor gene expression zones identified in the literature. In general, simulations predicted that odorants that were highly soluble in mucus were absorbed dorsally and medially, corresponding roughly to receptors from one of the gene expression zones. Insoluble odorants tended to be absorbed more peripherally in the rat olfactory region corresponding to the other 2 zones. These findings also agreed in general with the electroolfactogram measurements and the voltage-sensitive dye measurements reported in the literature. This numerical approach is the first to predict detailed odorant flux information across the olfactory mucosa in the rat nasal cavity during inspiratory and expiratory flow and to relate it to anatomic olfactory receptor location, physiological function, and biochemical experiment. This numerical technique can allow us to separate the contributions of imposed and inherent patterning mechanisms on the rat olfactory mucosa. |
| doi_str_mv | 10.1093/chemse/bjl056 |
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The computed surface mass flux distributions were compared with anatomic receptor gene expression zones identified in the literature. In general, simulations predicted that odorants that were highly soluble in mucus were absorbed dorsally and medially, corresponding roughly to receptors from one of the gene expression zones. Insoluble odorants tended to be absorbed more peripherally in the rat olfactory region corresponding to the other 2 zones. These findings also agreed in general with the electroolfactogram measurements and the voltage-sensitive dye measurements reported in the literature. This numerical approach is the first to predict detailed odorant flux information across the olfactory mucosa in the rat nasal cavity during inspiratory and expiratory flow and to relate it to anatomic olfactory receptor location, physiological function, and biochemical experiment. This numerical technique can allow us to separate the contributions of imposed and inherent patterning mechanisms on the rat olfactory mucosa.</description><identifier>ISSN: 0379-864X</identifier><identifier>EISSN: 1464-3553</identifier><identifier>DOI: 10.1093/chemse/bjl056</identifier><identifier>PMID: 17220517</identifier><identifier>CODEN: CHSED8</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>absorption ; Animals ; Biological and medical sciences ; Finite Element Analysis ; Fundamental and applied biological sciences. Psychology ; Models, Anatomic ; Models, Biological ; mucus solubility ; Nasal Cavity - physiology ; nasal fluid mechanics ; Nasal Mucosa - anatomy & histology ; Nasal Mucosa - physiology ; odorant flow rate ; Odorants ; Olfaction. Taste ; Perception ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Rats ; Rats, Sprague-Dawley ; receptor gene expression zones</subject><ispartof>Chemical senses, 2007-03, Vol.32 (3), p.273-284</ispartof><rights>The Author 2007. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oxfordjournals.org 2007</rights><rights>2007 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Mar 2007</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c489t-389174c378c5c612c4767b8e227809630ecc838cf229d42fb5a03567658048b33</citedby><cites>FETCH-LOGICAL-c489t-389174c378c5c612c4767b8e227809630ecc838cf229d42fb5a03567658048b33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,1579,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18691725$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17220517$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yang, Geoffrey C.</creatorcontrib><creatorcontrib>Scherer, Peter W.</creatorcontrib><creatorcontrib>Zhao, Kai</creatorcontrib><creatorcontrib>Mozell, Maxwell M.</creatorcontrib><title>Numerical Modeling of Odorant Uptake in the Rat Nasal Cavity</title><title>Chemical senses</title><addtitle>Chem Senses</addtitle><description>An anatomically accurate 3-dimensional numerical model of the right rat nasal cavity was developed and used to compute low, medium, and high flow rate inspiratory and expiratory mucosal odorant uptake (imposed patterning) for 3 odorants with different mucus solubilities. The computed surface mass flux distributions were compared with anatomic receptor gene expression zones identified in the literature. In general, simulations predicted that odorants that were highly soluble in mucus were absorbed dorsally and medially, corresponding roughly to receptors from one of the gene expression zones. Insoluble odorants tended to be absorbed more peripherally in the rat olfactory region corresponding to the other 2 zones. These findings also agreed in general with the electroolfactogram measurements and the voltage-sensitive dye measurements reported in the literature. This numerical approach is the first to predict detailed odorant flux information across the olfactory mucosa in the rat nasal cavity during inspiratory and expiratory flow and to relate it to anatomic olfactory receptor location, physiological function, and biochemical experiment. This numerical technique can allow us to separate the contributions of imposed and inherent patterning mechanisms on the rat olfactory mucosa.</description><subject>absorption</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Finite Element Analysis</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Models, Anatomic</subject><subject>Models, Biological</subject><subject>mucus solubility</subject><subject>Nasal Cavity - physiology</subject><subject>nasal fluid mechanics</subject><subject>Nasal Mucosa - anatomy & histology</subject><subject>Nasal Mucosa - physiology</subject><subject>odorant flow rate</subject><subject>Odorants</subject><subject>Olfaction. Taste</subject><subject>Perception</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>receptor gene expression zones</subject><issn>0379-864X</issn><issn>1464-3553</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0ElLxDAUwPEgio7L0asUQfFSzb6AFxncwB3FwUtIM6l27DImrei3N9Ki4MVTLj_ey_sDsIngPoKKHNgXVwV3kM1KyPgCGCHKaUoYI4tgBIlQqeR0sgJWQ5hBiCjBchmsIIExZEiMwOFVVzlfWFMml83UlUX9nDR5cj1tvKnb5GHemleXFHXSvrjkzrTJlQnRjs170X6ug6XclMFtDO8aeDg5vh-fpRfXp-fjo4vUUqnalEiFBLVESMssR9hSwUUmHcZCQsUJdNZKIm2OsZpSnGfMQMK44ExCKjNC1sBuP3fum7fOhVZXRbCuLE3tmi5oAQlnIt78H0SKMw4JjHD7D5w1na_jEdEozBUXMqK0R9Y3IXiX67kvKuM_NYL6O77u4-s-fvRbw9Auq9z0Vw-1I9gZgAmxeB4T2yL8OsljKPx9xl7vmm7-787hj0Vo3ccPNv5Vc0EE02eTJ317AwV9lDd6Qr4A_b6n3g</recordid><startdate>20070301</startdate><enddate>20070301</enddate><creator>Yang, Geoffrey C.</creator><creator>Scherer, Peter W.</creator><creator>Zhao, Kai</creator><creator>Mozell, Maxwell M.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QP</scope><scope>7QR</scope><scope>7SS</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>20070301</creationdate><title>Numerical Modeling of Odorant Uptake in the Rat Nasal Cavity</title><author>Yang, Geoffrey C. ; Scherer, Peter W. ; Zhao, Kai ; Mozell, Maxwell M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c489t-389174c378c5c612c4767b8e227809630ecc838cf229d42fb5a03567658048b33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>absorption</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Finite Element Analysis</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Models, Anatomic</topic><topic>Models, Biological</topic><topic>mucus solubility</topic><topic>Nasal Cavity - physiology</topic><topic>nasal fluid mechanics</topic><topic>Nasal Mucosa - anatomy & histology</topic><topic>Nasal Mucosa - physiology</topic><topic>odorant flow rate</topic><topic>Odorants</topic><topic>Olfaction. Taste</topic><topic>Perception</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>receptor gene expression zones</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yang, Geoffrey C.</creatorcontrib><creatorcontrib>Scherer, Peter W.</creatorcontrib><creatorcontrib>Zhao, Kai</creatorcontrib><creatorcontrib>Mozell, Maxwell M.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical senses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yang, Geoffrey C.</au><au>Scherer, Peter W.</au><au>Zhao, Kai</au><au>Mozell, Maxwell M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Numerical Modeling of Odorant Uptake in the Rat Nasal Cavity</atitle><jtitle>Chemical senses</jtitle><addtitle>Chem Senses</addtitle><date>2007-03-01</date><risdate>2007</risdate><volume>32</volume><issue>3</issue><spage>273</spage><epage>284</epage><pages>273-284</pages><issn>0379-864X</issn><eissn>1464-3553</eissn><coden>CHSED8</coden><abstract>An anatomically accurate 3-dimensional numerical model of the right rat nasal cavity was developed and used to compute low, medium, and high flow rate inspiratory and expiratory mucosal odorant uptake (imposed patterning) for 3 odorants with different mucus solubilities. The computed surface mass flux distributions were compared with anatomic receptor gene expression zones identified in the literature. In general, simulations predicted that odorants that were highly soluble in mucus were absorbed dorsally and medially, corresponding roughly to receptors from one of the gene expression zones. Insoluble odorants tended to be absorbed more peripherally in the rat olfactory region corresponding to the other 2 zones. These findings also agreed in general with the electroolfactogram measurements and the voltage-sensitive dye measurements reported in the literature. This numerical approach is the first to predict detailed odorant flux information across the olfactory mucosa in the rat nasal cavity during inspiratory and expiratory flow and to relate it to anatomic olfactory receptor location, physiological function, and biochemical experiment. This numerical technique can allow us to separate the contributions of imposed and inherent patterning mechanisms on the rat olfactory mucosa.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>17220517</pmid><doi>10.1093/chemse/bjl056</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | absorption Animals Biological and medical sciences Finite Element Analysis Fundamental and applied biological sciences. Psychology Models, Anatomic Models, Biological mucus solubility Nasal Cavity - physiology nasal fluid mechanics Nasal Mucosa - anatomy & histology Nasal Mucosa - physiology odorant flow rate Odorants Olfaction. Taste Perception Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Sprague-Dawley receptor gene expression zones |
| title | Numerical Modeling of Odorant Uptake in the Rat Nasal Cavity |
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