Value of fetal cerebral MRI in sonographically proven cardiac rhabdomyoma
Tuberous sclerosis complex (TSC) is an autosomal dominant phakomatosis associated with intracardiac rhabdomyomas. The aim of our study was to examine the value of cerebral MRI in diagnosing TSC in fetuses with intracardiac rhabdomyomas, applying the TSC Consensus Conference (TSCCC) criteria. In a pr...
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| Veröffentlicht in: | Pediatric radiology 2007-05, Vol.37 (5), p.467-474 |
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| creator | Mühler, Matthias R Rake, Annett Schwabe, Michael Schmidt, Susanne Kivelitz, Dietmar Chaoui, Rabih Hamm, Bernd |
| description | Tuberous sclerosis complex (TSC) is an autosomal dominant phakomatosis associated with intracardiac rhabdomyomas.
The aim of our study was to examine the value of cerebral MRI in diagnosing TSC in fetuses with intracardiac rhabdomyomas, applying the TSC Consensus Conference (TSCCC) criteria.
In a prospective manner six consecutive fetuses with cardiac rhabdomyomas (21-34 weeks' gestation) underwent cerebral MRI. The MRI results were correlated with clinical follow-up at 10-34 months after birth, histology, and genetic data.
In five of the six fetuses the diagnosis of TSC was established. In two of five fetuses MRI demonstrated cerebral manifestations of TSC that correlated well with severe epilepsy manifesting during the follow-up period. In another two of five fetuses MRI as well as clinical follow-up were normal. One of five pregnancies was terminated and histology demonstrated microscopically small subependymal nodules not demonstrated by MRI.
The results of our study agree with the available literature that fetal MRI is sufficient for the detection of cerebral lesions in TSC and should be better promoted. The TSCCC criteria can also be applied to fetal MRI. |
| doi_str_mv | 10.1007/s00247-007-0436-y |
| format | Article |
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The aim of our study was to examine the value of cerebral MRI in diagnosing TSC in fetuses with intracardiac rhabdomyomas, applying the TSC Consensus Conference (TSCCC) criteria.
In a prospective manner six consecutive fetuses with cardiac rhabdomyomas (21-34 weeks' gestation) underwent cerebral MRI. The MRI results were correlated with clinical follow-up at 10-34 months after birth, histology, and genetic data.
In five of the six fetuses the diagnosis of TSC was established. In two of five fetuses MRI demonstrated cerebral manifestations of TSC that correlated well with severe epilepsy manifesting during the follow-up period. In another two of five fetuses MRI as well as clinical follow-up were normal. One of five pregnancies was terminated and histology demonstrated microscopically small subependymal nodules not demonstrated by MRI.
The results of our study agree with the available literature that fetal MRI is sufficient for the detection of cerebral lesions in TSC and should be better promoted. The TSCCC criteria can also be applied to fetal MRI.</description><identifier>ISSN: 0301-0449</identifier><identifier>EISSN: 1432-1998</identifier><identifier>DOI: 10.1007/s00247-007-0436-y</identifier><identifier>PMID: 17357805</identifier><language>eng</language><publisher>Germany: Springer Nature B.V</publisher><subject>Brain - pathology ; Child, Preschool ; Female ; Fetal Diseases - diagnosis ; Fetal Diseases - diagnostic imaging ; Follow-Up Studies ; Heart Neoplasms - complications ; Heart Neoplasms - diagnosis ; Heart Neoplasms - diagnostic imaging ; Humans ; Infant ; Magnetic Resonance Imaging - methods ; Myocardium - pathology ; Observer Variation ; Predictive Value of Tests ; Pregnancy ; Prospective Studies ; Rhabdomyoma - complications ; Rhabdomyoma - diagnosis ; Rhabdomyoma - diagnostic imaging ; Tuberous Sclerosis - complications ; Tuberous Sclerosis - diagnosis ; Ultrasonography, Doppler ; Ultrasonography, Prenatal</subject><ispartof>Pediatric radiology, 2007-05, Vol.37 (5), p.467-474</ispartof><rights>Springer-Verlag 2007</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c392t-52bfbaa34b1e483dbb5ee8148ca00015f37f60ba372e7f9e998ec89747170de03</citedby><cites>FETCH-LOGICAL-c392t-52bfbaa34b1e483dbb5ee8148ca00015f37f60ba372e7f9e998ec89747170de03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17357805$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mühler, Matthias R</creatorcontrib><creatorcontrib>Rake, Annett</creatorcontrib><creatorcontrib>Schwabe, Michael</creatorcontrib><creatorcontrib>Schmidt, Susanne</creatorcontrib><creatorcontrib>Kivelitz, Dietmar</creatorcontrib><creatorcontrib>Chaoui, Rabih</creatorcontrib><creatorcontrib>Hamm, Bernd</creatorcontrib><title>Value of fetal cerebral MRI in sonographically proven cardiac rhabdomyoma</title><title>Pediatric radiology</title><addtitle>Pediatr Radiol</addtitle><description>Tuberous sclerosis complex (TSC) is an autosomal dominant phakomatosis associated with intracardiac rhabdomyomas.
The aim of our study was to examine the value of cerebral MRI in diagnosing TSC in fetuses with intracardiac rhabdomyomas, applying the TSC Consensus Conference (TSCCC) criteria.
In a prospective manner six consecutive fetuses with cardiac rhabdomyomas (21-34 weeks' gestation) underwent cerebral MRI. The MRI results were correlated with clinical follow-up at 10-34 months after birth, histology, and genetic data.
In five of the six fetuses the diagnosis of TSC was established. In two of five fetuses MRI demonstrated cerebral manifestations of TSC that correlated well with severe epilepsy manifesting during the follow-up period. In another two of five fetuses MRI as well as clinical follow-up were normal. One of five pregnancies was terminated and histology demonstrated microscopically small subependymal nodules not demonstrated by MRI.
The results of our study agree with the available literature that fetal MRI is sufficient for the detection of cerebral lesions in TSC and should be better promoted. The TSCCC criteria can also be applied to fetal MRI.</description><subject>Brain - pathology</subject><subject>Child, Preschool</subject><subject>Female</subject><subject>Fetal Diseases - diagnosis</subject><subject>Fetal Diseases - diagnostic imaging</subject><subject>Follow-Up Studies</subject><subject>Heart Neoplasms - complications</subject><subject>Heart Neoplasms - diagnosis</subject><subject>Heart Neoplasms - diagnostic imaging</subject><subject>Humans</subject><subject>Infant</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Myocardium - pathology</subject><subject>Observer Variation</subject><subject>Predictive Value of Tests</subject><subject>Pregnancy</subject><subject>Prospective Studies</subject><subject>Rhabdomyoma - complications</subject><subject>Rhabdomyoma - diagnosis</subject><subject>Rhabdomyoma - diagnostic imaging</subject><subject>Tuberous Sclerosis - complications</subject><subject>Tuberous Sclerosis - diagnosis</subject><subject>Ultrasonography, Doppler</subject><subject>Ultrasonography, Prenatal</subject><issn>0301-0449</issn><issn>1432-1998</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2007</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpdkM1LxDAQxYMo7vrxB3iR4sFbdZJpN-1RFj8WFEHUa0jSqdulbdZkK_S_N8suCJ7mwbx5vPkxdsHhhgPI2wAgMplGmUKGs3Q8YFOeoUh5WRaHbAoIPG6ycsJOQlgBAOYcj9mES8xlAfmULT51O1Di6qSmjW4TS56Mj-LlbZE0fRJc7768Xi8bq9t2TNbe_VCfWO2rRtvEL7WpXDe6Tp-xo1q3gc7385R9PNy_z5_S59fHxfzuObVYik2aC1MbrTEznLICK2NyooJnhdWxH89rlPUMjEYpSNYlxU_IFqXMJJdQEeApu97lxirfA4WN6ppgqW11T24ISgLOsJQYjVf_jCs3-D52U0KIWVmg2Kbxncl6F4KnWq1902k_Kg5qC1ntIKut3EJWY7y53AcPpqPq72JPFX8BumB3LA</recordid><startdate>20070501</startdate><enddate>20070501</enddate><creator>Mühler, Matthias R</creator><creator>Rake, Annett</creator><creator>Schwabe, Michael</creator><creator>Schmidt, Susanne</creator><creator>Kivelitz, Dietmar</creator><creator>Chaoui, Rabih</creator><creator>Hamm, Bernd</creator><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQGLB</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20070501</creationdate><title>Value of fetal cerebral MRI in sonographically proven cardiac rhabdomyoma</title><author>Mühler, Matthias R ; Rake, Annett ; Schwabe, Michael ; Schmidt, Susanne ; Kivelitz, Dietmar ; Chaoui, Rabih ; Hamm, Bernd</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c392t-52bfbaa34b1e483dbb5ee8148ca00015f37f60ba372e7f9e998ec89747170de03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2007</creationdate><topic>Brain - pathology</topic><topic>Child, Preschool</topic><topic>Female</topic><topic>Fetal Diseases - diagnosis</topic><topic>Fetal Diseases - diagnostic imaging</topic><topic>Follow-Up Studies</topic><topic>Heart Neoplasms - complications</topic><topic>Heart Neoplasms - diagnosis</topic><topic>Heart Neoplasms - diagnostic imaging</topic><topic>Humans</topic><topic>Infant</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Myocardium - pathology</topic><topic>Observer Variation</topic><topic>Predictive Value of Tests</topic><topic>Pregnancy</topic><topic>Prospective Studies</topic><topic>Rhabdomyoma - complications</topic><topic>Rhabdomyoma - diagnosis</topic><topic>Rhabdomyoma - diagnostic imaging</topic><topic>Tuberous Sclerosis - complications</topic><topic>Tuberous Sclerosis - diagnosis</topic><topic>Ultrasonography, Doppler</topic><topic>Ultrasonography, Prenatal</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mühler, Matthias R</creatorcontrib><creatorcontrib>Rake, Annett</creatorcontrib><creatorcontrib>Schwabe, Michael</creatorcontrib><creatorcontrib>Schmidt, Susanne</creatorcontrib><creatorcontrib>Kivelitz, Dietmar</creatorcontrib><creatorcontrib>Chaoui, Rabih</creatorcontrib><creatorcontrib>Hamm, Bernd</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection (ProQuest)</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Applied & Life Sciences</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric radiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mühler, Matthias R</au><au>Rake, Annett</au><au>Schwabe, Michael</au><au>Schmidt, Susanne</au><au>Kivelitz, Dietmar</au><au>Chaoui, Rabih</au><au>Hamm, Bernd</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Value of fetal cerebral MRI in sonographically proven cardiac rhabdomyoma</atitle><jtitle>Pediatric radiology</jtitle><addtitle>Pediatr Radiol</addtitle><date>2007-05-01</date><risdate>2007</risdate><volume>37</volume><issue>5</issue><spage>467</spage><epage>474</epage><pages>467-474</pages><issn>0301-0449</issn><eissn>1432-1998</eissn><abstract>Tuberous sclerosis complex (TSC) is an autosomal dominant phakomatosis associated with intracardiac rhabdomyomas.
The aim of our study was to examine the value of cerebral MRI in diagnosing TSC in fetuses with intracardiac rhabdomyomas, applying the TSC Consensus Conference (TSCCC) criteria.
In a prospective manner six consecutive fetuses with cardiac rhabdomyomas (21-34 weeks' gestation) underwent cerebral MRI. The MRI results were correlated with clinical follow-up at 10-34 months after birth, histology, and genetic data.
In five of the six fetuses the diagnosis of TSC was established. In two of five fetuses MRI demonstrated cerebral manifestations of TSC that correlated well with severe epilepsy manifesting during the follow-up period. In another two of five fetuses MRI as well as clinical follow-up were normal. One of five pregnancies was terminated and histology demonstrated microscopically small subependymal nodules not demonstrated by MRI.
The results of our study agree with the available literature that fetal MRI is sufficient for the detection of cerebral lesions in TSC and should be better promoted. The TSCCC criteria can also be applied to fetal MRI.</abstract><cop>Germany</cop><pub>Springer Nature B.V</pub><pmid>17357805</pmid><doi>10.1007/s00247-007-0436-y</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0301-0449 |
| ispartof | Pediatric radiology, 2007-05, Vol.37 (5), p.467-474 |
| issn | 0301-0449 1432-1998 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70363973 |
| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Brain - pathology Child, Preschool Female Fetal Diseases - diagnosis Fetal Diseases - diagnostic imaging Follow-Up Studies Heart Neoplasms - complications Heart Neoplasms - diagnosis Heart Neoplasms - diagnostic imaging Humans Infant Magnetic Resonance Imaging - methods Myocardium - pathology Observer Variation Predictive Value of Tests Pregnancy Prospective Studies Rhabdomyoma - complications Rhabdomyoma - diagnosis Rhabdomyoma - diagnostic imaging Tuberous Sclerosis - complications Tuberous Sclerosis - diagnosis Ultrasonography, Doppler Ultrasonography, Prenatal |
| title | Value of fetal cerebral MRI in sonographically proven cardiac rhabdomyoma |
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