Vitamin D status and its association with parathyroid hormone concentrations in women of child-bearing age living in Jakarta and Kuala Lumpur
Objective: To describe the vitamin D status of women living in two Asian cities, - Jakarta (6°S) and Kuala-Lumpur (2°N), to examine the association between plasma 25-hydroxyvitamin D and parathyroid hormone (PTH) concentrations, and to determine a threshold for plasma 25-hydroxyvitamin D above which...
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| Veröffentlicht in: | European journal of clinical nutrition 2008-03, Vol.62 (3), p.373-378 |
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| creator | Green, T.J Skeaff, C.M Rockell, J.E.P Venn, B.J Lambert, A Todd, J Khor, G.L Loh, S.P Muslimatun, S Agustina, R |
| description | Objective: To describe the vitamin D status of women living in two Asian cities, - Jakarta (6°S) and Kuala-Lumpur (2°N), to examine the association between plasma 25-hydroxyvitamin D and parathyroid hormone (PTH) concentrations, and to determine a threshold for plasma 25-hydroxyvitamin D above which there is no further suppression of PTH. Also, to determine whether dietary calcium intake influences the relationship between PTH and 25-hydroxyvitamin D. Design: Cross-sectional. Setting: Jakarta, Indonesia and Kuala Lumpur, Malaysia. Participants: A convenience sample of 504 non-pregnant women 18-40 years. Main measures: Plasma 25-hydroxyvitamin D and PTH. Results: The mean 25-hydroxyvitamin D concentration was 48 nmol/l. Less than 1% of women had a 25-hydroxyvitamin D concentration indicative of vitamin D deficiency ( |
| doi_str_mv | 10.1038/sj.ejcn.1602696 |
| format | Article |
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Also, to determine whether dietary calcium intake influences the relationship between PTH and 25-hydroxyvitamin D. Design: Cross-sectional. Setting: Jakarta, Indonesia and Kuala Lumpur, Malaysia. Participants: A convenience sample of 504 non-pregnant women 18-40 years. Main measures: Plasma 25-hydroxyvitamin D and PTH. Results: The mean 25-hydroxyvitamin D concentration was 48 nmol/l. Less than 1% of women had a 25-hydroxyvitamin D concentration indicative of vitamin D deficiency (<17.5 nmol/l); whereas, over 60% of women had a 25-hydroxyvitamin D concentration indicative of insufficiency (<50 nmol/l). We estimate that 52 nmol/l was the threshold concentration for plasma 25-hydroxyvitamin D above which no further suppression of PTH occurred. Below and above this concentration the slopes of the regression lines were -0.18 (different from 0; P=0.003) and -0.01 (P=0.775), respectively. The relation between vitamin D status and parathyroid hormone concentration did not differ between women with low, medium or high calcium intakes (P=0.611); however, even in the highest tertile of calcium intake, mean calcium intake was only 657 mg/d. Conclusion: On the basis of maximal suppression of PTH we estimate an optimal 25-hydroxyvitamin D concentration of 50 nmol/l. Many women had a 25-hydroxyvitamin D below this concentration and may benefit from improved vitamin D status.</description><identifier>ISSN: 0954-3007</identifier><identifier>EISSN: 1476-5640</identifier><identifier>DOI: 10.1038/sj.ejcn.1602696</identifier><identifier>PMID: 17342165</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>25-hydroxycholecalciferol ; 25-hydroxyergocalciferol ; 25-Hydroxyvitamin D ; Adolescent ; Adult ; Alfacalcidol ; Biological and medical sciences ; blood chemistry ; Calcifediol ; Calciferol ; Calcium ; Calcium (dietary) ; Clinical Nutrition ; Cross-Sectional Studies ; Diet ; Dietary intake ; Epidemiology ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Health aspects ; hormone metabolism ; Hormones ; Humans ; Indonesia ; Internal Medicine ; Malaysia ; Medical sciences ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Nutrient deficiency ; nutrient intake ; nutrient reserves ; Nutrition ; nutrition assessment ; Nutritional aspects ; Nutritional Status ; original-article ; Parathyroid ; Parathyroid hormone ; Parathyroid Hormone - blood ; Plasma ; Public Health ; Thyroid gland ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; Vitamin D Deficiency - blood ; Vitamin D Deficiency - physiopathology ; vitamin deficiencies ; Vitamin deficiency ; Women ; Women's Health</subject><ispartof>European journal of clinical nutrition, 2008-03, Vol.62 (3), p.373-378</ispartof><rights>Springer Nature Limited 2008</rights><rights>2008 INIST-CNRS</rights><rights>COPYRIGHT 2008 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Mar 2008</rights><rights>Nature Publishing Group 2008.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c616t-9475b33f85170c123f2502fb31ecadf548c1dceccb001e5f5f10074e2f4bd0573</citedby><cites>FETCH-LOGICAL-c616t-9475b33f85170c123f2502fb31ecadf548c1dceccb001e5f5f10074e2f4bd0573</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sj.ejcn.1602696$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sj.ejcn.1602696$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27922,27923,41486,42555,51317</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20137094$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/17342165$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Green, T.J</creatorcontrib><creatorcontrib>Skeaff, C.M</creatorcontrib><creatorcontrib>Rockell, J.E.P</creatorcontrib><creatorcontrib>Venn, B.J</creatorcontrib><creatorcontrib>Lambert, A</creatorcontrib><creatorcontrib>Todd, J</creatorcontrib><creatorcontrib>Khor, G.L</creatorcontrib><creatorcontrib>Loh, S.P</creatorcontrib><creatorcontrib>Muslimatun, S</creatorcontrib><creatorcontrib>Agustina, R</creatorcontrib><title>Vitamin D status and its association with parathyroid hormone concentrations in women of child-bearing age living in Jakarta and Kuala Lumpur</title><title>European journal of clinical nutrition</title><addtitle>Eur J Clin Nutr</addtitle><addtitle>Eur J Clin Nutr</addtitle><description>Objective: To describe the vitamin D status of women living in two Asian cities, - Jakarta (6°S) and Kuala-Lumpur (2°N), to examine the association between plasma 25-hydroxyvitamin D and parathyroid hormone (PTH) concentrations, and to determine a threshold for plasma 25-hydroxyvitamin D above which there is no further suppression of PTH. Also, to determine whether dietary calcium intake influences the relationship between PTH and 25-hydroxyvitamin D. Design: Cross-sectional. Setting: Jakarta, Indonesia and Kuala Lumpur, Malaysia. Participants: A convenience sample of 504 non-pregnant women 18-40 years. Main measures: Plasma 25-hydroxyvitamin D and PTH. Results: The mean 25-hydroxyvitamin D concentration was 48 nmol/l. Less than 1% of women had a 25-hydroxyvitamin D concentration indicative of vitamin D deficiency (<17.5 nmol/l); whereas, over 60% of women had a 25-hydroxyvitamin D concentration indicative of insufficiency (<50 nmol/l). We estimate that 52 nmol/l was the threshold concentration for plasma 25-hydroxyvitamin D above which no further suppression of PTH occurred. Below and above this concentration the slopes of the regression lines were -0.18 (different from 0; P=0.003) and -0.01 (P=0.775), respectively. The relation between vitamin D status and parathyroid hormone concentration did not differ between women with low, medium or high calcium intakes (P=0.611); however, even in the highest tertile of calcium intake, mean calcium intake was only 657 mg/d. Conclusion: On the basis of maximal suppression of PTH we estimate an optimal 25-hydroxyvitamin D concentration of 50 nmol/l. Many women had a 25-hydroxyvitamin D below this concentration and may benefit from improved vitamin D status.</description><subject>25-hydroxycholecalciferol</subject><subject>25-hydroxyergocalciferol</subject><subject>25-Hydroxyvitamin D</subject><subject>Adolescent</subject><subject>Adult</subject><subject>Alfacalcidol</subject><subject>Biological and medical sciences</subject><subject>blood chemistry</subject><subject>Calcifediol</subject><subject>Calciferol</subject><subject>Calcium</subject><subject>Calcium (dietary)</subject><subject>Clinical Nutrition</subject><subject>Cross-Sectional Studies</subject><subject>Diet</subject><subject>Dietary intake</subject><subject>Epidemiology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Health aspects</subject><subject>hormone metabolism</subject><subject>Hormones</subject><subject>Humans</subject><subject>Indonesia</subject><subject>Internal Medicine</subject><subject>Malaysia</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metabolic Diseases</subject><subject>Nutrient deficiency</subject><subject>nutrient intake</subject><subject>nutrient reserves</subject><subject>Nutrition</subject><subject>nutrition assessment</subject><subject>Nutritional aspects</subject><subject>Nutritional Status</subject><subject>original-article</subject><subject>Parathyroid</subject><subject>Parathyroid hormone</subject><subject>Parathyroid Hormone - blood</subject><subject>Plasma</subject><subject>Public Health</subject><subject>Thyroid gland</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>Vitamin D Deficiency - blood</subject><subject>Vitamin D Deficiency - physiopathology</subject><subject>vitamin deficiencies</subject><subject>Vitamin deficiency</subject><subject>Women</subject><subject>Women's Health</subject><issn>0954-3007</issn><issn>1476-5640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kk1v1DAQhiMEoqVw5gRYIHrL1o5jOzlW5ZuVOEC5RhPH3vWS2IvtUPVH8J9xNqsuoFY-2PI8M69n_GbZU4IXBNPqLGwWaiPtgnBc8Jrfy45JKXjOeInvZ8e4ZmVOMRZH2aMQNhinoCgeZkdE0LIgnB1nv7-bCIOx6A0KEeIYENgOmZj2EJw0EI2z6MrENdqCh7i-9s50aO384KxC0lmpbPQ7LKBU58oNyiKnkVybvstbBd7YFYKVQr35NR0T9Al-gI-w0_o8Qg9oOQ7b0T_OHmjog3qy30-yy3dvv118yJdf3n-8OF_mkhMe87oUrKVUV4wILElBdcFwoVtKlIROs7KSpJNKyja1rJhmmqQhlKrQZdthJuhJdjrX3Xr3c1QhNoMJUvU9WOXG0AhMOS0JSeCr_8CNG71Nb2sKXhaCshpP5V7eSZGac8qLOkH5DK2gV42x2qWxyZWyykOfZqlNuj4noqYMVzt-cQufVqcGI29NOP0rYa2gj-vg-nH3Nf-CZzMovQvBK91svRnAXzcEN5OtmrBpJls1e1uljOf7Bsd2UN2B3_soAa_3AAQJvfZgpQk3XIEJFbguE4dnLmwnWyh_mNTd2s_mFJvs6dVB-yb-Yo5rcA2sfJK9_DoJYlwJXhcV_QPXufi_</recordid><startdate>20080301</startdate><enddate>20080301</enddate><creator>Green, T.J</creator><creator>Skeaff, C.M</creator><creator>Rockell, J.E.P</creator><creator>Venn, B.J</creator><creator>Lambert, A</creator><creator>Todd, J</creator><creator>Khor, G.L</creator><creator>Loh, S.P</creator><creator>Muslimatun, S</creator><creator>Agustina, R</creator><general>Nature Publishing Group UK</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7TK</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20080301</creationdate><title>Vitamin D status and its association with parathyroid hormone concentrations in women of child-bearing age living in Jakarta and Kuala Lumpur</title><author>Green, T.J ; Skeaff, C.M ; Rockell, J.E.P ; Venn, B.J ; Lambert, A ; Todd, J ; Khor, G.L ; Loh, S.P ; Muslimatun, S ; Agustina, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c616t-9475b33f85170c123f2502fb31ecadf548c1dceccb001e5f5f10074e2f4bd0573</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2008</creationdate><topic>25-hydroxycholecalciferol</topic><topic>25-hydroxyergocalciferol</topic><topic>25-Hydroxyvitamin D</topic><topic>Adolescent</topic><topic>Adult</topic><topic>Alfacalcidol</topic><topic>Biological and medical sciences</topic><topic>blood chemistry</topic><topic>Calcifediol</topic><topic>Calciferol</topic><topic>Calcium</topic><topic>Calcium (dietary)</topic><topic>Clinical Nutrition</topic><topic>Cross-Sectional Studies</topic><topic>Diet</topic><topic>Dietary intake</topic><topic>Epidemiology</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Health aspects</topic><topic>hormone metabolism</topic><topic>Hormones</topic><topic>Humans</topic><topic>Indonesia</topic><topic>Internal Medicine</topic><topic>Malaysia</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metabolic Diseases</topic><topic>Nutrient deficiency</topic><topic>nutrient intake</topic><topic>nutrient reserves</topic><topic>Nutrition</topic><topic>nutrition assessment</topic><topic>Nutritional aspects</topic><topic>Nutritional Status</topic><topic>original-article</topic><topic>Parathyroid</topic><topic>Parathyroid hormone</topic><topic>Parathyroid Hormone - blood</topic><topic>Plasma</topic><topic>Public Health</topic><topic>Thyroid gland</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>Vitamin D Deficiency - blood</topic><topic>Vitamin D Deficiency - 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Academic</collection><jtitle>European journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Green, T.J</au><au>Skeaff, C.M</au><au>Rockell, J.E.P</au><au>Venn, B.J</au><au>Lambert, A</au><au>Todd, J</au><au>Khor, G.L</au><au>Loh, S.P</au><au>Muslimatun, S</au><au>Agustina, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Vitamin D status and its association with parathyroid hormone concentrations in women of child-bearing age living in Jakarta and Kuala Lumpur</atitle><jtitle>European journal of clinical nutrition</jtitle><stitle>Eur J Clin Nutr</stitle><addtitle>Eur J Clin Nutr</addtitle><date>2008-03-01</date><risdate>2008</risdate><volume>62</volume><issue>3</issue><spage>373</spage><epage>378</epage><pages>373-378</pages><issn>0954-3007</issn><eissn>1476-5640</eissn><abstract>Objective: To describe the vitamin D status of women living in two Asian cities, - Jakarta (6°S) and Kuala-Lumpur (2°N), to examine the association between plasma 25-hydroxyvitamin D and parathyroid hormone (PTH) concentrations, and to determine a threshold for plasma 25-hydroxyvitamin D above which there is no further suppression of PTH. Also, to determine whether dietary calcium intake influences the relationship between PTH and 25-hydroxyvitamin D. Design: Cross-sectional. Setting: Jakarta, Indonesia and Kuala Lumpur, Malaysia. Participants: A convenience sample of 504 non-pregnant women 18-40 years. Main measures: Plasma 25-hydroxyvitamin D and PTH. Results: The mean 25-hydroxyvitamin D concentration was 48 nmol/l. Less than 1% of women had a 25-hydroxyvitamin D concentration indicative of vitamin D deficiency (<17.5 nmol/l); whereas, over 60% of women had a 25-hydroxyvitamin D concentration indicative of insufficiency (<50 nmol/l). We estimate that 52 nmol/l was the threshold concentration for plasma 25-hydroxyvitamin D above which no further suppression of PTH occurred. Below and above this concentration the slopes of the regression lines were -0.18 (different from 0; P=0.003) and -0.01 (P=0.775), respectively. The relation between vitamin D status and parathyroid hormone concentration did not differ between women with low, medium or high calcium intakes (P=0.611); however, even in the highest tertile of calcium intake, mean calcium intake was only 657 mg/d. Conclusion: On the basis of maximal suppression of PTH we estimate an optimal 25-hydroxyvitamin D concentration of 50 nmol/l. Many women had a 25-hydroxyvitamin D below this concentration and may benefit from improved vitamin D status.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>17342165</pmid><doi>10.1038/sj.ejcn.1602696</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0954-3007 |
| ispartof | European journal of clinical nutrition, 2008-03, Vol.62 (3), p.373-378 |
| issn | 0954-3007 1476-5640 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_70363411 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; SpringerLink Journals - AutoHoldings |
| subjects | 25-hydroxycholecalciferol 25-hydroxyergocalciferol 25-Hydroxyvitamin D Adolescent Adult Alfacalcidol Biological and medical sciences blood chemistry Calcifediol Calciferol Calcium Calcium (dietary) Clinical Nutrition Cross-Sectional Studies Diet Dietary intake Epidemiology Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Health aspects hormone metabolism Hormones Humans Indonesia Internal Medicine Malaysia Medical sciences Medicine Medicine & Public Health Metabolic Diseases Nutrient deficiency nutrient intake nutrient reserves Nutrition nutrition assessment Nutritional aspects Nutritional Status original-article Parathyroid Parathyroid hormone Parathyroid Hormone - blood Plasma Public Health Thyroid gland Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood Vitamin D Deficiency - blood Vitamin D Deficiency - physiopathology vitamin deficiencies Vitamin deficiency Women Women's Health |
| title | Vitamin D status and its association with parathyroid hormone concentrations in women of child-bearing age living in Jakarta and Kuala Lumpur |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T11%3A33%3A00IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_proqu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Vitamin%20D%20status%20and%20its%20association%20with%20parathyroid%20hormone%20concentrations%20in%20women%20of%20child-bearing%20age%20living%20in%20Jakarta%20and%20Kuala%20Lumpur&rft.jtitle=European%20journal%20of%20clinical%20nutrition&rft.au=Green,%20T.J&rft.date=2008-03-01&rft.volume=62&rft.issue=3&rft.spage=373&rft.epage=378&rft.pages=373-378&rft.issn=0954-3007&rft.eissn=1476-5640&rft_id=info:doi/10.1038/sj.ejcn.1602696&rft_dat=%3Cgale_proqu%3EA179350829%3C/gale_proqu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=219663629&rft_id=info:pmid/17342165&rft_galeid=A179350829&rfr_iscdi=true |