Properties of H7N7 influenza A virus strain SC35M lacking interferon antagonist NS1 in mice and chickens

Non-structural protein NS1 of influenza A virus counteracts the host immune response by blocking the synthesis of type I interferon (IFN). As deletion of the complete NS1 gene has to date been reported only in the human H1N1 strain A/PR/8/34, it remained unclear whether NS1 is a non-essential virule...

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Veröffentlicht in:	Journal of general virology 2007-05, Vol.88 (5), p.1403-1409
Hauptverfasser:	Kochs, G, Koerner, I, Thiel, L, Kothlow, S, Kaspers, B, Ruggli, N, Summerfield, A, Pavlovic, J, Stech, J, Staeheli, P
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals bioassays Biological and medical sciences Cell Line Cercopithecus aethiops Chickens Dogs Fundamental and applied biological sciences. Psychology gene deletion host-pathogen relationships Humans immune response Influenza A virus Influenza A Virus, H7N7 Subtype - classification Influenza A Virus, H7N7 Subtype - isolation & purification Influenza A Virus, H7N7 Subtype - physiology Influenza in Birds - immunology Influenza, Human Interferon-beta - genetics interferons Interferons - antagonists & inhibitors Lung - immunology Lung - virology Mice Microbiology Miscellaneous mutants non-structural proteins NS1 protein Orthomyxoviridae Infections pathogenicity phenotype respiratory system Reverse Transcriptase Polymerase Chain Reaction Vero Cells viral diseases of animals and humans Viral Nonstructural Proteins - deficiency viral proteins Virology Virulence virus replication
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