2,5-Disubstituted pyridines : The discovery of a novel series of 5-HT2A ligands

This report describes the effect of replacing the central basic amine present in many known 5-HT(2A) ligands with an aromatic residue. We targeted the isomeric phenethylpyridines 2 and 3 and these compounds proved to be excellent leads, possessing good 5-HT(2A) receptor binding affinity and selectiv...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2007-05, Vol.17 (9), p.2643-2648
Hauptverfasser:	WILSON, Kevin J, VAN NIEL, Monique B, COOPER, Laura, BLOOMFIELD, Dawn, O'CONNOR, Desmond, FISH, L. Rebecca, MACLEOD, Angus M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Chemistry, Pharmaceutical - methods Drug Design Humans Kinetics Ligands Medical sciences Models, Chemical Molecular Conformation Neuropharmacology Neurotransmitters. Neurotransmission. Receptors Pharmacology. Drug treatments Pyridines - chemical synthesis Pyridines - chemistry Pyridines - pharmacology Rats Receptor, Serotonin, 5-HT2A - chemistry Serotonin Antagonists - chemical synthesis Serotonin Antagonists - chemistry Serotonin Antagonists - pharmacology Serotoninergic system Sulfones - chemistry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!