Differential modulation of 3T3-L1 adipogenesis mediated by 11beta-hydroxysteroid dehydrogenase-1 levels

The localized activation of circulating glucocorticoids in vivo by the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) plays a critical role in the development of the metabolic syndrome. However, the precise contribution of 11beta-HSD1 in the initiation of adipogenesis by inactive gl...

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Veröffentlicht in:	The Journal of biological chemistry 2007-04, Vol.282 (15), p.11038-11046
Hauptverfasser:	Kim, Jaime, Temple, Karla A, Jones, Sara A, Meredith, Kimberly N, Basko, Juliana L, Brady, Matthew J
Format:	Artikel
Sprache:	eng
Schlagworte:	11-beta-Hydroxysteroid Dehydrogenase Type 1 - genetics 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism 3T3-L1 Cells Adipocytes - cytology Adipocytes - enzymology Adipogenesis Animals Gene Expression Regulation, Enzymologic Glucocorticoids - metabolism Mice Molecular Sequence Data RNA Interference Up-Regulation
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